Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Flora Chik"'
1
Pharmacological methyl group donors block skeletal metastasisin vitroandin vivo
Autor: Flora Chik, Shafaat A. Rabbani, Moshe Szyf, Ani Arakelian, Surabhi Parashar, Nicholas Shukeir, Barbara Stefanska
Publikováno v: British Journal of Pharmacology. 172:2769-2781
Background and Purpose DNA hypomethylation was previously implicated in metastasis. In the present study, we examined whether methyl supplementation with the universal methyl donor S-adenosylmethionine (SAM) inhibits prostate cancer associated skelet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5731b17808750a4ccb081dfc2a0338fa
https://doi.org/10.1111/bph.13102
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2
Akademický článek
Patient preferences for treatment attributes in moderate-to-severe atopic dermatitis: a discrete choice experiment.
Autor: Feldman, Steven R.1, Guerin, Annie2, Gauthier-Loiselle, Marjolaine2, Claxton, Ami J.3, Hazra, Nisha C.4 Nisha.Hazra@analysisgroup.com, Meng, Yan4, Gallant, Kirsten4, Balu, Sanjeev3
Publikováno v: Journal of Dermatological Treatment. Dec2024, Vol. 35 Issue 1, p1-9. 9p.
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3
Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness
Autor: Moshe Szyf, Michael Hallett, Bishnu Bhattacharya, Chen Chen Li, Matthew Suderman, Ani Arakelian, Flora Chik, Shafaat A. Rabbani, David Cheishvili
Publikováno v: Carcinogenesis. 35(11)
5-Aza-2ʹ-deoxycytidine (5-azaCdR) not only inhibits growth of non-invasive breast cancer cells but also increases their invasiveness through induction of pro-metastatic genes. Methylated DNA binding protein 2 (MBD2) is involved in silencing methylat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fe10ef9ca617da84d89305b541b784
https://pubmed.ncbi.nlm.nih.gov/25178277
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4
Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine
Autor: Flora Chik, Moshe Szyf, Ziv Machnes
Publikováno v: Carcinogenesis. 35(1)
DNA-demethylating agents activate tumor suppressor genes that are silenced by DNA methylation in cancer and are therefore emerging as a novel approach to cancer therapy. 5-azacytidine (VIDAZA), the first representative of this class of drugs was appr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1a6334c1446a35df53a516b6e9a781
https://pubmed.ncbi.nlm.nih.gov/23985780
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5
Akademický článek
Treatment Preferences of Adult Patients with Attention-Deficit/Hyperactivity Disorder – A Discrete Choice Experiment.
Autor: Schein, Jeff (AUTHOR), Cloutier, Martin (AUTHOR), Gauthier-Loiselle, Marjolaine (AUTHOR), Catillon, Maryaline (AUTHOR), Meng, Yan (AUTHOR), Libchaber, Beatrice (AUTHOR), Jiang, Fanny (AUTHOR), Childress, Ann (AUTHOR)
Publikováno v: Patient Preference & Adherence. Aug2024, Vol. 18, p1651-1664. 14p.
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6
Akademický článek
Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study.
Autor: Muntoni, Francesco1 (AUTHOR), Signorovitch, James2,3 (AUTHOR) James.signorovitch@analysisgroup.com, Sajeev, Gautam2 (AUTHOR), Done, Nicolae2 (AUTHOR), Yao, Zhiwen2 (AUTHOR), Goemans, Nathalie4 (AUTHOR), McDonald, Craig5 (AUTHOR), Mercuri, Eugenio6 (AUTHOR), Niks, Erik H.7 (AUTHOR), Wong, Brenda8 (AUTHOR), Vandenborne, Krista9 (AUTHOR), Straub, Volker10 (AUTHOR), de Groot, Imelda J. M.11 (AUTHOR), Tian, Cuixia12 (AUTHOR), Manzur, Adnan1 (AUTHOR), Dieye, Ibrahima2 (AUTHOR), Lane, Henry2 (AUTHOR), Ward, Susan J.3 (AUTHOR), Servais, Laurent13,14 (AUTHOR)
Publikováno v: PLoS ONE. 7/10/2024, Vol. 19 Issue 7, p1-18. 18p.
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8
Role of epigenetics in cancer initiation and progression
Autor: Flora, Chik, Moshe, Szyf, Shafaat A, Rabbani
Publikováno v: Advances in experimental medicine and biology. 720
The epigenome which comprises DNA methylation, histone modifications, chromatin structures and non-coding RNAs controls gene expression patterns. In cancer cells, there are aberrant changes in the epigenome. The question in cancer epigenetics is that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0280e6595bdb518fe2e9d6d5472de42
https://pubmed.ncbi.nlm.nih.gov/21901621
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9
Role of Epigenetics in Cancer Initiation and Progression
Autor: Flora Chik, Moshe Szyf, Shafaat A. Rabbani
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461402534
The epigenome which comprises DNA methylation, histone modifications, chromatin structures and non-coding RNAs controls gene expression patterns. In cancer cells, there are aberrant changes in the epigenome. The question in cancer epigenetics is that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c38dabd3e7dec592fac338baf3f764ac
https://doi.org/10.1007/978-1-4614-0254-1_8
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10
Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors
Autor: Moshe Szyf, Flora Chik
Publikováno v: Carcinogenesis. 32(2)
A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug develo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15b82e64ee014e0ce87c9bcfd62fbe6
https://pubmed.ncbi.nlm.nih.gov/20980350
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