Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Flora Cheng"'
Autor:
Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106421- (2024)
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43. A hurdle to the use of cyclin F, however, is that th
Externí odkaz:
https://doaj.org/article/938a323b072b422dbb397509b51afada
Autor:
Shuying Sun, Flora Cheng, Daphne Han, Sarah Wei, Alice Zhong, Sherwin Massoudian, Alison B. Johnson
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background A haplotype is a set of DNA variants inherited together from one parent or chromosome. Haplotype information is useful for studying genetic variation and disease association. Haplotype assembly (HA) is a process of obtaining haplo
Externí odkaz:
https://doaj.org/article/bd0c75580d614fc2b92a784a5d6f1765
Autor:
Stephanie L. Rayner, Shu Yang, Natalie E. Farrawell, Cyril J. Jagaraj, Flora Cheng, Jennilee M. Davidson, Luan Luu, Alberto G. Redondo, Alberto Rábano, Daniel Borrego-Hernández, Julie D. Atkin, Marco Morsch, Ian P. Blair, Justin J. Yerbury, Roger Chung, Albert Lee
Publikováno v:
Neurobiology of Disease, Vol 167, Iss , Pp 105673- (2022)
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared p
Externí odkaz:
https://doaj.org/article/8b0375252ae3453588b0ea1234e98d29
Autor:
Jennilee M. Davidson, Stephanie L. Rayner, Sidong Liu, Flora Cheng, Antonio Di Ieva, Roger S. Chung, Albert Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4283 (2023)
Proteomics offers vast potential for studying the molecular regulation of the human brain. Formalin fixation is a common method for preserving human tissue; however, it presents challenges for proteomic analysis. In this study, we compared the effici
Externí odkaz:
https://doaj.org/article/3fd12b2efb2949c0a9035dfd3554f0f9
Autor:
Flora Cheng, Alana De Luca, Alison L. Hogan, Stephanie L. Rayner, Jennilee M. Davidson, Maxinne Watchon, Claire H. Stevens, Sonia Sanz Muñoz, Lezanne Ooi, Justin J. Yerbury, Emily K. Don, Jennifer A. Fifita, Maria D. Villalva, Hannah Suddull, Tyler R. Chapman, Thomas J. Hedl, Adam K. Walker, Shu Yang, Marco Morsch, Bingyang Shi, Ian P. Blair, Angela S. Laird, Roger S. Chung, Albert Lee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical
Externí odkaz:
https://doaj.org/article/6d9d5478214e4a43b5c90d1b2ff9a16b
Autor:
Thomas J. Hedl, Rebecca San Gil, Flora Cheng, Stephanie L. Rayner, Jennilee M. Davidson, Alana De Luca, Maria D. Villalva, Heath Ecroyd, Adam K. Walker, Albert Lee
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS
Externí odkaz:
https://doaj.org/article/9fb158da4d31476494289e43bada051d
Publikováno v:
Proteomes, Vol 8, Iss 3, p 21 (2020)
PeptideWitch is a python-based web module that introduces several key graphical and technical improvements to the Scrappy software platform, which is designed for label-free quantitative shotgun proteomics analysis using normalised spectral abundance
Externí odkaz:
https://doaj.org/article/36f71217fd1a4b7ebbc85979bc251d27
Autor:
Rowan A. W. Radford, Stephanie L. Rayner, Paulina Szwaja, Marco Morsch, Flora Cheng, Tianyi Zhu, Jocelyn Widagdo, Victor Anggono, Dean L. Pountney, Roger Chung, Albert Lee
Publikováno v:
Journal of Neurochemistry. 165:563-586
Autor:
Jennilee M. Davidson, Sharlynn S. L. Wu, Stephanie L. Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M. Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L. Williams, Marco Morsch, Ian P. Blair, Antonio Di Ieva, Shu Yang, Roger S. Chung, Albert Lee
Publikováno v:
Molecular Neurobiology.
Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCFcyclinF known
Autor:
Sidong Liu, Antonio Di Ieva, Jennilee Davidson, Stephanie Rayner, Roger Chung, Albert Lee, Flora Cheng
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 5
Pages: 4283
Volume 24
Issue 5
Pages: 4283
Proteomics offers vast potential for studying the molecular regulation of the human brain. Formalin fixation is a common method for preserving human tissue; however, it presents challenges for proteomic analysis. In this study, we compared the effici