Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation.

Autor: Herppich S; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Hoenicke L; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Kern F; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, Saarland University, Saarbrücken, Germany.; Department of Clinical Bioinformatics, Saarland University, Homburg, Germany., Kruse F; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Smout J; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Greweling-Pils MC; Mouse Pathology Platform, Helmholtz Centre for Infection Research, Braunschweig, Germany., Geffers R; Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany., Burton OT; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK., Liston A; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK., Keller A; Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, Saarland University, Saarbrücken, Germany.; Department of Clinical Bioinformatics, Saarland University, Homburg, Germany., Floess S; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Huehn J; Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Publikováno v: European journal of immunology [Eur J Immunol] 2023 Oct; Vol. 53 (10), pp. e2250270. Date of Electronic Publication: 2023 Jun 27.

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

Autor: Yang, B-H, Hagemann, S, Mamareli, P, Lauer, U, Hoffmann, U, Beckstette, M, Föhse, L, Prinz, I, Pezoldt, J, Suerbaum, S, Sparwasser, T, Hamann, A, Floess, S, Huehn, J, Lochner, M

Publikováno v: In Mucosal Immunology March 2016 9(2):444-457

Identification of the novel FOXP3-dependent T reg cell transcription factor MEOX1 by high-dimensional analysis of human CD4 ⁺ T cells.

Autor: Baßler K; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Bonn, Germany., Schmidleithner L; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Shakiba MH; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Elmzzahi T; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia., Köhne M; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Floess S; Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Scholz R; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Ohkura N; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan., Sadlon T; Molecular Immunology, Robinson Research Institute, University of Adelaide, Norwich Centre, North Adelaide, SA, Australia., Klee K; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Bonn, Germany., Neubauer A; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Sakaguchi S; Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan., Barry SC; Molecular Immunology, Robinson Research Institute, University of Adelaide, Norwich Centre, North Adelaide, SA, Australia., Huehn J; Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Bonaguro L; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Bonn, Germany., Ulas T; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Bonn, Germany.; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany., Beyer M; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jul 25; Vol. 14, pp. 1107397. Date of Electronic Publication: 2023 Jul 25 (Print Publication: 2023).

K 2P 18.1 translates T cell receptor signals into thymic regulatory T cell development.

Autor: Ruck T; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de.; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany. tobias.ruck@med.uni-duesseldorf.de., Bock S; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Pfeuffer S; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Schroeter CB; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Cengiz D; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Marciniak P; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Lindner M; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Herrmann A; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Liebmann M; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Kovac S; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Gola L; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Rolfes L; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Pawlitzki M; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Opel N; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Pap T; Institute of Experimental Musculoskeletal Medicine (IMM), University of Münster, Münster, Germany., Luessi F; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Schreiber JA; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany., Wünsch B; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany., Kuhlmann T; Institute of Neuropathology, University of Münster, Münster, Germany., Seebohm G; Cellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany., Tackenberg B; Department of Neurology, Philipps-University, Marburg, Germany., Seja P; Laboratory of Neurobiology, University of Helsinki, Helsinki, Finland., Döring F; Molecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany., Wischmeyer E; Molecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany., Chasan AI; Institute of Immunology, University of Münster, Münster, Germany., Roth J; Institute of Immunology, University of Münster, Münster, Germany., Klotz L; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Marschall T; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Floess S; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Huehn J; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Budde T; Institute for Physiology I, University of Münster, Münster, Germany., Bopp T; Institute of Immunology, Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Bittner S; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Meuth SG; Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.

Publikováno v: Cell research [Cell Res] 2022 Jan; Vol. 32 (1), pp. 72-88. Date of Electronic Publication: 2021 Oct 26.

Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34 ⁺ stromal cell subsets.

Autor: Pezoldt J; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Wiechers C; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany., Zou M; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany., Litovchenko M; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Biocanin M; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Beckstette M; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine, Helmholtz Centre for Infection Research and Hannover Medical School, 30625, Hannover, Germany.; Genome Informatics Group, Bielefeld Institute for Bioinformatics Infrastructure, Department of Technology, Bielefeld University, 33615, Bielefeld, Germany., Sitnik K; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria., Palatella M; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany., van Mierlo G; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Chen W; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Gardeux V; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Floess S; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany., Ebel M; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany., Russeil J; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Arampatzi P; Core Unit Systems Medicine, University of Wuerzburg, 97080, Wuerzburg, Germany., Vafardanejad E; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI), 97080, Würzburg, Germany., Saliba AE; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI), 97080, Würzburg, Germany., Deplancke B; Laboratory of Systems Biology and Genetics, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Huehn J; Department Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany. jochen.huehn@helmholtz-hzi.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625, Hannover, Germany. jochen.huehn@helmholtz-hzi.de.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 24; Vol. 13 (1), pp. 7227. Date of Electronic Publication: 2022 Nov 24.