Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Flobert Tanga"'
Autor:
George N. Nikov, Grace Bi, Benito Munoz, Matthew G. Stanton, Matthew T. Tudge, Richard E. Middleton, Jamie L. Crispino, Peter Sajonz, Mark S. Shearman, Black Regina M, Minilik Angagaw, Paula Andrade, Eric Fan, Flobert Tanga, Jonathan C. Cruz, Alexander A. Szewczak, Nirah H. Shomer, Bethany Hughes, Sanjiv J. Shah, Georgia Farris, Christopher Hamblett, Jed L. Hubbs, David L. Sloman, Candia M. Kenific
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:755-758
We report herein a novel series of difluoropiperidine acetic acids as modulators of gamma-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective beta-difluorination with Selectfluor. Compounds 1f and 2
Autor:
Sujal V. Deshmukh, Susan L. Zultanski, George N. Nikov, Christopher M. Moxham, Armetta D. Hill, Lily Y. Moy, Nadya Smotrov, Christian Fischer, Hua Zhou, Joey L. Methot, Maria S. Michener, Bethany Hughes, Damaris Diaz, Zhenhua Wu, Jacquelynn J. Cook, Sanjiv J. Shah, Benito Munoz, Jonathan C. Cruz, Flobert Tanga, Nathan Bays, Melanie Bouthillette, Bo-Sheng Pan, Valentina V. Jeliazkova-Mecheva, Ikuo Hayashi, Mark S. Shearman, Candia M. Kenific, Deborah Walker
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discover
Autor:
George N. Nikov, Flobert Tanga, Chris Moxham, Ziping Yang, Chaomin Li, Richard G. Ball, Joshua Close, Richard W. Heidebrecht, Gloria Y. Kwei, Lin Xu, Laura Surdi, Xiaoliu Geng, Candia Kenefic, Sanjiv J. Shah, Dan F. Savage, Valentina V. Jeliazkova-Mecheva, Jennifer Chapnick, Julie Elizabeth Burke, Solomon Kattar, Bethany Hughes, Lily Y. Moy, Sujal V. Deshmukh, Paul Moses, Damaris Diaz, John Kevin Leach, Paul Tempest, John Hendrix, Amanda Markarewicz, Nadya Smotrov, Ilona Kariv, Michael J. McNevin, Ben Munoz, Mark S. Shearman, Thomas A. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
Alzheimer’s disease is a major unmet medical need with pathology characterized by extracellular proteinaceous plaques comprised primarily of β-amyloid. γ-Secretase is a critical enzyme in the cellular pathway responsible for the formation of a ra
Autor:
Michelle Martinez, Mark S. Shearman, Thomas A. Miller, Yudith Garcia, Alexey Rivkin, Christopher M. Moxham, George N. Nikov, Christopher Hamblett, Laura Surdi, Joon Jung, Sean P. Ahearn, Benito Munoz, Andrew Rosenau, Lily Y. Moy, Flobert Tanga, Minilik Angagaw, Jed L. Hubbs, Richard E. Middleton, Matthew H. Daniels, Phieng Siliphaivanh, Sanjiv J. Shah, Candia M. Kenific, Alexander A. Szewczak, Jamie L. Crispino, Jonathan C. Cruz, Bethany Hughes, Nirah H. Shomer, Stephanie M. Chichetti, Chaomin Li, Karin M. Otte, Michael H. Reutershan, Paula Andrade
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-base