Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.

Autor: Steadman VA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Pettit SB; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Poullennec KG; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Lazarides L; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Keats AJ; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Dean DK; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Stanway SJ; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Austin CA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Sanvoisin JA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Watt GM; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom., Fliri HG; Cypralis Ltd. , Babraham Research Campus, Cambridge CB22 3AT, United Kingdom., Liclican AC; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Jin D; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Wong MH; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Leavitt SA; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Lee YJ; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Tian Y; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Frey CR; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Appleby TC; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Schmitz U; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Jansa P; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Mackman RL; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States., Schultz BE; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 09; Vol. 60 (3), pp. 1000-1017. Date of Electronic Publication: 2017 Jan 31.

Bimatoprost, prostamide activity, and conventional drainage.

Autor: Wan Z; Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85711, USA., Woodward DF, Cornell CL, Fliri HG, Martos JL, Pettit SN, Wang JW, Kharlamb AB, Wheeler LA, Garst ME, Landsverk KJ, Struble CS, Stamer WD

Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2007 Sep; Vol. 48 (9), pp. 4107-15.