Výsledky vyhledávání - "Flippin Lee Allen"

Isolation of the Acetylcholinesterase Inhibitor Ungeremine from Nerine bowdenii by Preparative HPLC Coupled On-Line to a Flow Assay System

Autor: Natalie Appels, Robert Verpoorte, Bertil Hofte, In Kyung Rhee, Flippin Lee Allen, Lucy M. Stark, Bahadir Karabatak, Cornelis Erkelens

Publikováno v: Biological and Pharmaceutical Bulletin. 27:1804-1809

In an attempt to isolate the active compound while detecting acetylcholinesterase inhibitory activity, we applied a fluorometric flow assay system to an on-line coupled preparative HPLC. The MeOH extract of Nerine bowdenii showed a strong inhibitory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4aca407fec65fb2c4bf0bdcc0f89ccd
https://doi.org/10.1248/bpb.27.1804

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

Autor: Richard M. Eglen, Tess Pulido-Rios, Saul Jaime, Cindy Rocha, Flippin Lee Allen, Mark Dawson, E. Leung, Graeme R. Martin, Robert Greenhouse, Kristine Van Natta, L K Chang, Andrea Webber, Douglas W. Bonhaus

Publikováno v: British Journal of Pharmacology. 127:1075-1082

Efforts to define precisely the role of 5-HT2B receptors in normal and disease processes have been hindered by the absence of selective antagonists. To address this deficiency, we developed a series of naphthylpyrimidines as potentially useful 5-HT2B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a87e1f04819abfd7a86970c50c7bb391
https://doi.org/10.1038/sj.bjp.0702632

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Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines

Autor: Aubry K. Miller, Flippin Lee Allen, Zhao Shu-Hai, Berger Jacob

Publikováno v: Tetrahedron Letters. 37:4463-4466

A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08458fe2a35c548b2ea44ee1d47e2e95
https://doi.org/10.1016/0040-4039(96)00877-5

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Rs-100235: A high affinity 5-HT4 receptor antagonist

Autor: Richard M. Eglen, E.H.F. Wong, Flippin Lee Allen, L.G. Johnson, Robin D. Clark, Alam Jahangir, Douglas W. Bonhaus, E. Leung, James Langston

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2119-2122

The 1,4-benzodioxanyl ketone 14 (RS-100235) was found to be high affinity 5-HT 4 antagonist with potent in vivo activity and a sustained duration of action in the anesthetized pig.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84003d258ad37ebdbc52b99665f94d13
https://doi.org/10.1016/0960-894x(95)00358-z

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Directed metalation of aromatic aldimines with lithium 2,2,6,6-tetramethylpiperidide

Autor: Joseph M. Muchowski, David S. Carter, Flippin Lee Allen

Publikováno v: The Journal of Organic Chemistry. 58:2463-2467

N-Cyclohexyl aromatic aldimines are ortho-lithiated or o-methyl-lithiated with 2 equiv of lithium 2,2,6,6-tetramethylpiperidide (LTMP) in THF solution at -15 o C. The lithiated intermediates generally reacted with allyl halides or CO 2 to provide ort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2276f78b11741237630c5470eb21ba64
https://doi.org/10.1021/jo00061a020

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