Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Flint Stevenson-Jones"'
Autor:
Matthias W. Hentze, K.N. Sathish Yadav, Gabriele Neu-Yilik, Beate Amthor, Joshua C. Bufton, Jonas Philipp Becker, Dakang Shen, Kyle T. Powers, Andreas E. Kulozik, Flint Stevenson-Jones, Ufuk Borucu, Christiane Schaffitzel, Daria Lavysh
Publikováno v:
Nucleic Acids Research
Powers, K T, Stevenson-Jones, F R, Yadav Kadapalakere, S, Bufton, J C, Borucu, U, Shen, D & Berger-Schaffitzel, C H 2021, ' Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA ', Nucleic Acids Research, vol. 49, no. 13, pp. 7665-7679 . https://doi.org/10.1093/nar/gkab532
Powers, K T, Stevenson-Jones, F R, Yadav Kadapalakere, S, Bufton, J C, Borucu, U, Shen, D & Berger-Schaffitzel, C H 2021, ' Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA ', Nucleic Acids Research, vol. 49, no. 13, pp. 7665-7679 . https://doi.org/10.1093/nar/gkab532
Deciphering translation is of paramount importance for the understanding of many diseases, and antibiotics played a pivotal role in this endeavour. Blasticidin S (BlaS) targets translation by binding to the peptidyl transferase center of the large ri
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Transcription and translation are coupled in bacteria, meaning that translation of the nascent mRNA by ribosome happens simultaneously with its synthesis by RNA polymerase (RNAP). Uncoupling of transcription from translation may lead to
Autor:
Samo Turk, Stephan Buckenmaier, Benjamin Zeuch, Nhat Khai Bui, Stanislav Gobec, Waldemar Vollmer, Flint Stevenson-Jones
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2011, ⟨10.1016/j.bcp.2011.03.028⟩
Biochemical Pharmacology, Elsevier, 2011, ⟨10.1016/j.bcp.2011.03.028⟩
The essential cell wall peptidoglycan is the target of several components of the innate immune system and its disruption results in lysis of invading bacteria. The pathogen Streptococcus pneumoniae produces a peptidoglycan N-acetylglucosamine deacety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b9c3d4da6d64ea213b2263a74c8941
https://hal.archives-ouvertes.fr/hal-00701258
https://hal.archives-ouvertes.fr/hal-00701258