Split intein-mediated protein trans-splicing to express large dystrophins.

Autor: Tasfaout H; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. tasfaout@uw.edu.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA. tasfaout@uw.edu., Halbert CL; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA., McMillen TS; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, WA, USA., Allen JM; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA., Reyes TR; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA., Flint GV; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, WA, USA., Grimm D; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty and Faculty of Engineering Sciences, Center for Integrative Infectious Disease Research (CIID), University of Heidelberg, Heidelberg, Germany.; BioQuant, University of Heidelberg, Heidelberg, Germany.; German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), Heidelberg, Germany., Hauschka SD; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA., Regnier M; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA.; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, WA, USA.; Center for Translational Muscle Research, University of Washington, Seattle, WA, USA., Chamberlain JS; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. jsc5@uw.edu.; Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, University of Washington School of Medicine, Seattle, WA, USA. jsc5@uw.edu.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA. jsc5@uw.edu.; Center for Translational Muscle Research, University of Washington, Seattle, WA, USA. jsc5@uw.edu.

Publikováno v: Nature [Nature] 2024 Aug; Vol. 632 (8023), pp. 192-200. Date of Electronic Publication: 2024 Jul 17.

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts.

Autor: Powers JD; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA., Kooiker KB; Division of Cardiology, School of Medicine, University of Washington, Seattle, Washington, USA., Mason AB; Department of Chemistry and Biochemistry, College of Science, and., Teitgen AE; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA., Flint GV; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA., Tardiff JC; Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, Arizona, USA., Schwartz SD; Department of Chemistry and Biochemistry, College of Science, and., McCulloch AD; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA., Regnier M; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA., Davis J; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA., Moussavi-Harami F; Division of Cardiology, School of Medicine, University of Washington, Seattle, Washington, USA.

Publikováno v: JCI insight [JCI Insight] 2020 Oct 15; Vol. 5 (20). Date of Electronic Publication: 2020 Oct 15.

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.

Autor: Powers JD; Department of Bioengineering, University of Washington, Seattle, WA 98109; j2powers@ucsd.edu mregnier@uw.edu.; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093., Yuan CC; Department of Bioengineering, University of Washington, Seattle, WA 98109., McCabe KJ; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093., Murray JD; Department of Bioengineering, University of Washington, Seattle, WA 98109.; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98109., Childers MC; Department of Bioengineering, University of Washington, Seattle, WA 98109., Flint GV; Department of Bioengineering, University of Washington, Seattle, WA 98109., Moussavi-Harami F; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98109., Mohran S; Department of Bioengineering, University of Washington, Seattle, WA 98109., Castillo R; Department of Bioengineering, University of Washington, Seattle, WA 98109., Zuzek C; Department of Bioengineering, University of Washington, Seattle, WA 98109., Ma W; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616., Daggett V; Department of Bioengineering, University of Washington, Seattle, WA 98109., McCulloch AD; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093., Irving TC; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616., Regnier M; Department of Bioengineering, University of Washington, Seattle, WA 98109; j2powers@ucsd.edu mregnier@uw.edu.; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 04; Vol. 116 (23), pp. 11502-11507. Date of Electronic Publication: 2019 May 20.

Contractility and kinetics of human fetal and human adult skeletal muscle.

Autor: Racca AW; Department of Bioengineering, University of Washington, Seattle, WA, USA., Beck AE, Rao VS, Flint GV, Lundy SD, Born DE, Bamshad MJ, Regnier M

Publikováno v: The Journal of physiology [J Physiol] 2013 Jun 15; Vol. 591 (12), pp. 3049-61. Date of Electronic Publication: 2013 Apr 29.