Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content.

Autor: Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA., Martinez GJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA., Bates EA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA., Maharramov AB; Department of Pharmacology and Nutritional Sciences, University of Kentucky, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA., Flight RM; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40508, USA., Moseley HNB; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.; Institute for Biomedical Informatics, University of Kentucky, Lexington, KY 40508, USA.; Center for Clinical and Translational Sciences, University of Kentucky, Lexington, KY 40508, USA., Morris AJ; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Stec DE; Department of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS 39216, USA., Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky, 760 Press Avenue, Healthy Kentucky Research Building, Lexington, KY 40508, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.; Barnstable Brown Diabetes Center, University of Kentucky, Lexington, KY 40508, USA.

Publikováno v: Metabolites [Metabolites] 2023 Feb 01; Vol. 13 (2). Date of Electronic Publication: 2023 Feb 01.

Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents.

Autor: Creeden JF; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA., Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Xu M; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Flight RM; Department of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.; Resource Center for Stable Isotope Resolved Metabolomics, University of Kentucky, Lexington, Kentucky, USA., Moseley HNB; Department of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.; Resource Center for Stable Isotope Resolved Metabolomics, University of Kentucky, Lexington, Kentucky, USA.; Institute for Biomedical Informatics, University of Kentucky, Lexington, Kentucky, USA.; Center for Clinical and Translational Science, University of Kentucky, Lexington, Kentucky, USA., Martinez GJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Lee WH; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Alganem K; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA., Imami AS; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA., McMullen MR; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA., Roychowdhury S; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA., Nawabi AM; Division of Transplant and Hepatobiliary, Department of Surgery, The University of Kansas Medical Center, Kansas City, Kansas, USA., Hipp JA; Strata Oncology, Ann Arbor, Michigan, USA., Softic S; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA.; Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA., Weinman SA; Department of Internal Medicine and Liver Center, University of Kansas Medical Center, Kansas City, Kansas, USA., McCullumsmith R; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.; Neurosciences Institute, ProMedica, Toledo, Ohio, USA., Nagy LE; Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Gastroenterology and Hepatology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.; Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2022 Nov; Vol. 76 (5), pp. 1376-1388. Date of Electronic Publication: 2022 Apr 08.

Cellular Origins of EGFR-Driven Lung Cancer Cells Determine Sensitivity to Therapy.

Autor: Chen F; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Liu J; Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA., Flight RM; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Naughton KJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Lukyanchuk A; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Edgin AR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Song X; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Zhang H; DNAtrix, 10355 Science Center Drive, Suite 110, San Diego, CA, 92121, USA., Wong KK; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, NY, 10016, USA., Moseley HNB; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Wang C; Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2021 Nov; Vol. 8 (22), pp. e2101999. Date of Electronic Publication: 2021 Oct 07.

Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium.

Autor: Zhong Y; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States., Mohan K; Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, United States., Liu J; Markey Cancer Center, University of Kentucky, Lexington, KY, United States., Al-Attar A; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Lin P; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Flight RM; Markey Cancer Center, University of Kentucky, Lexington, KY, United States; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Sun Q; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Warmoes MO; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Deshpande RR; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States., Liu H; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States., Jung KS; Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, United States., Mitov MI; Markey Cancer Center, University of Kentucky, Lexington, KY, United States., Lin N; Pfizer Inc., San Diego, CA, United States., Butterfield DA; Markey Cancer Center, University of Kentucky, Lexington, KY, United States; Department of Chemistry, University of Kentucky, Lexington, KY, United States., Lu S; Pfizer Inc., San Diego, CA, United States., Liu J; Markey Cancer Center, University of Kentucky, Lexington, KY, United States; Department of Computer Science, University of Kentucky, Lexington, KY, United States; Institute for Biomedical Informatics, University of Kentucky, Lexington, KY, United States., Moseley HNB; Markey Cancer Center, University of Kentucky, Lexington, KY, United States; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States; Institute for Biomedical Informatics, University of Kentucky, Lexington, KY, United States., Fan TWM; Markey Cancer Center, University of Kentucky, Lexington, KY, United States; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, United States; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States., Kleinman ME; Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, United States., Wang QJ; Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY, United States; Markey Cancer Center, University of Kentucky, Lexington, KY, United States. Electronic address: qingjun.wang@uky.edu.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Oct 01; Vol. 1866 (10), pp. 165883. Date of Electronic Publication: 2020 Jun 25.

Dataset for dose and time-dependent transcriptional response to ionizing radiation exposure.

Autor: Rouchka EC; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40292, United States.; Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY, 40292, United States., Flight RM; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40356, United States., Fasciotto BH; Department of Electrical and Computer Engineering, University of Louisville, Louisville, KY, 40292, United States.; The ElectroOptics Research Institute and Nanotechnology Center, University of Louisville, Louisville, KY, 40292, United States., Estrada R; Department of Bioengineering, University of Louisville, Louisville, KY, 40292, United States., Eaton JW; Department of Medicine, University of Louisville, Louisville, KY, 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40292, United States.; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, United States., Patibandla PK; Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, United States.; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, United States., Waigel SJ; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, United States., Li D; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40292, United States., Kirtley JK; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40292, United States., Sethu P; Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, United States.; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, United States., Keynton RS; Department of Bioengineering, University of Louisville, Louisville, KY, 40292, United States.

Publikováno v: Data in brief [Data Brief] 2019 Oct 05; Vol. 27, pp. 104624. Date of Electronic Publication: 2019 Oct 05 (Print Publication: 2019).