Intranasal immunization with outer membrane vesicles (OMV) protects against airway colonization and systemic infection with Acinetobacter baumannii

Autor: Higham, Sophie L., Baker, Stephen, Flight, Katie E., Krishna, Aishwarya, Kellam, Paul, Reece, Stephen T., Tregoning, John S.

Publikováno v: In Journal of Infection June 2023 86(6):563-573

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

Autor: Adams, Kirsty, Amini, Fahimah, Atako, Nafisah B, Bakri, Amalina, Barclay, Wendy, Brodnicki, Elizabeth, Brown, Jonathan C, Byrne, Ruth, Chilvers, Rowena, Coelho, Sofia, Day, Suzanne, Desai, Monica, Dorman, Eleanor, Elliott, Tamara, Flight, Katie E, Fletcher, James, Galang, John, Gohil, Jagruti, Gupta, Aneta, Harlow, Chris, Hu, Kai, Kalyan, Mohini, Lagrue, Dominic, Liscano, Ely, Njenga, Cecilia, Polra, Krunal, Powlette, Derecia A, Randell, Paul, Rauchenberger, Mary, Redknap, Ianto, Ricamara, Maravic, Rogers, Paul, Sallah, Hadijatou, Samnuan, Karnyart, Schumacher, Michael, Shah, Zareena, Shaw, Rachel, Shaw, Thomas, Sivapatham, Stefan, Slater, Susie, Sorley, Kim, Storch, Regina, Tan, Elizabeth, Tan, Tricia, Thielemans, Lieze, Whitely, Sarah, Valentine, Charlotte, Varghese, Jeeva, Vikraman, Asha, Wilkins, Martin, Pollock, Katrina M., Cheeseman, Hannah M., Szubert, Alexander J., Libri, Vincenzo, Boffito, Marta, Owen, David, Bern, Henry, McFarlane, Leon R., O'Hara, Jessica, Lemm, Nana-Marie, McKay, Paul, Rampling, Tommy, Yim, Yee Ting N., Milinkovic, Ana, Kingsley, Cherry, Cole, Tom, Fagerbrink, Susanne, Aban, Marites, Tanaka, Maniola, Mehdipour, Savviz, Robbins, Alexander, Budd, William, Faust, Saul, Hassanin, Hana, Cosgrove, Catherine A., Winston, Alan, Fidler, Sarah, Dunn, David, McCormack, Sheena, Shattock, Robin J.

Publikováno v: In eClinicalMedicine February 2022 44

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K zobrazení výsledku je třeba se přihlásit.

Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines.

Autor: Tregoning JS; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Stirling DC; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Wang Z; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Flight KE; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Brown JC; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Blakney AK; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., McKay PF; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Cunliffe RF; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Murugaiah V; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK., Fox CB; IDRI, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Beattie M; Acuitas Therapeutics, 6190 Agronomy Road, Ste 405, Vancouver, BC, Canada., Tam YK; Acuitas Therapeutics, 6190 Agronomy Road, Ste 405, Vancouver, BC, Canada., Johansson C; National Heart and Lung Institute, Imperial College London, St. Mary's Campus, London, UK., Shattock RJ; Department of Infectious Disease, Imperial College London, St. Mary's Campus, London, UK.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2022 Dec 05; Vol. 31, pp. 29-42. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2023).