Twin study identifies early immunological and metabolic dysregulation of CD8⁺ T cells in multiple sclerosis.

Autor: Kavaka, Vladyslav, Mutschler, Luisa, de la Rosa del Val, Clara, Eglseer, Klara, Gómez Martínez, Ana M., Flierl-Hecht, Andrea, Ertl-Wagner, Birgit, Keeser, Daniel, Mortazavi, Martin, Seelos, Klaus, Zimmermann, Hanna, Haas, Jürgen, Wildemann, Brigitte, Kümpfel, Tania, Dornmair, Klaus, Korn, Thomas, Hohlfeld, Reinhard, Kerschensteiner, Martin, Gerdes, Lisa Ann, Beltrán, Eduardo

Publikováno v: Science Immunology; 2024, Vol. 9 Issue 99, p1-16, 16p

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Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

Autor: Tilman Schneider-Hohendorf, Lisa Ann Gerdes, Béatrice Pignolet, Rachel Gittelman, Patrick Ostkamp, Florian Rubelt, Catarina Raposo, Björn Tackenberg, Marianne Riepenhausen, Claudia Janoschka, Christian Wünsch, Florence Bucciarelli, Andrea Flierl-Hecht, Eduardo Beltrán, Tania Kümpfel, Katja Anslinger, Catharina C. Gross, Heidi Chapman, Ian Kaplan, David Brassat, Hartmut Wekerle, Martin Kerschensteiner, Luisa Klotz, Jan D. Lünemann, Reinhard Hohlfeld, Roland Liblau, Heinz Wiendl, Nicholas Schwab

Publikováno v: Journal of Experimental Medicine. 219

Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T cell reaction was suggested in MS, we queried peripheral blood T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8564553a252b3c3c4e7289ce08bbd74a
https://doi.org/10.1084/jem.20220650

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Autor: Martin Kerschensteiner, Chris Lauber, Lisa Ann Gerdes, Horst Penkert, Reinhard Hohlfeld, Dirk Fitzner, Tania Kümpfel, Mathias J. Gerl, Markus Damm, Mikael Simons, Andrea Flierl-Hecht, Christian Klose

Publikováno v: Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology 7(12), 2461-2466 (2020). doi:10.1002/acn3.51216

Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f15e40027bd288e70015a39f9a058a
http://europepmc.org/articles/PMC7732246

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