Výsledky vyhledávání - "Fleur Ruijne"

Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides

Autor: Yuxin Fu, Yanli Xu, Fleur Ruijne, Oscar P Kuipers

Publikováno v: FEMS Microbiology Reviews. 47

Natural bioactive peptide discovery is a challenging and time-consuming process. However, advances in synthetic biology are providing promising new avenues in peptide engineering that allow for the design and production of a large variety of new-to-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2bbb3e852de388d2e71605068eef485
https://doi.org/10.1093/femsre/fuad017

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Investigating the Specificity of the Dehydration and Cyclization Reactions in Engineered Lanthipeptides by Synechococcal SyncM

Autor: Patricia Arias-Orozco, Yunhai Yi, Fleur Ruijne, Rubén Cebrián, Oscar P. Kuipers

Publikováno v: ACS Synthetic Biology, 12. AMER CHEMICAL SOC

ProcM-like enzymes are class II promiscuous lanthipeptide synthetases that are an attractive tool in synthetic biology for producing lanthipeptides with biotechnological or clinically desired properties. SyncM is a recently described modification enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66df61d72202a696d75faf179ac418fd
https://research.rug.nl/en/publications/faa8ddd7-0987-401c-aba4-c2d3ff36859e

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Emulating nonribosomal peptides with ribosomal biosynthetic strategies

Autor: Silja Mordhorst, Fleur Ruijne, Anna L. Vagstad, Oscar P. Kuipers, Jörn Piel

Publikováno v: RSC Chemical Biology, 4 (1)
RSC Chemical Biology, 4, 7-36

Peptide natural products are important lead structures for human drugs and many nonribosomal peptides possess antibiotic activity. This makes them interesting targets for engineering approaches to generate peptide analogues with, for example, increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2abf53c86232f462beb0d0055095cc
https://hdl.handle.net/20.500.11850/592436

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Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials

Autor: Oscar P. Kuipers, Fleur Ruijne

Publikováno v: Biochemical Society Transactions, 49(1):BST20200425, 203-215. PORTLAND PRESS LTD

Natural peptide products are a valuable source of important therapeutic agents, including antibiotics, antivirals and crop protection agents. Aided by an increased understanding of structure–activity relationships of these complex molecules and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf518f4738d76e5d13f1f2d9e4a629da
https://research.rug.nl/en/publications/fc80db37-e485-45cb-803e-8ba70e4ec518

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