Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Fleur O'Hare"'
Autor:
Fred K Chen, Alex W Hewitt, Alan Ma, John Grigg, Keith R Martin, Robyn Jamieson, Heather G Mack, Fleur O’Hare, David Mackey, John De Roach, Alexis Ceecee Britten-Jones, Myra McGuinness, Nicole Tindill, Lauren Ayton, Anai Gonzalez Cordero, Thomas L Edwards, Gladys Ho, Michael Hogden, Anthony Kwan, Tina Lamey, Terri McLaren, Benjamin Nash, Jon Ruddle, Matthew Simunovic, Ingrid Sinnerbrink, Deepa Ajay Taranath, Jen Thompson, Jaclyn White
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction Voretigene neparvovec-rzyl (Luxturna) was approved by the Australian Therapeutic Goods Administration on 4 August 2020 for the treatment of biallelic mutations in the RPE65 gene, a rare cause of congenital and adult-onset retinal dystrop
Externí odkaz:
https://doaj.org/article/748c300353da46cfad1dfa7d7e12385a
Autor:
Fleur O'Hare, Simone Spark, Zachary Flanagan, Stephane Heritier, Andrea Curtis, Sophia Zoungas
Publikováno v:
Contemporary Clinical Trials Communications, Vol 11, Iss , Pp 89-94 (2018)
Aims: To compare recruitment, refusal and randomisation rates of older adults into a general practice-based clinical trial with two versions (varied format, content and language) of the Participant Information and Consent Form (PICF). Methods: This p
Externí odkaz:
https://doaj.org/article/427122d5f2894fc0ae39ca15f6a41f87
Survey of perspectives of people with inherited retinal diseases on ocular gene therapy in Australia
Autor:
Heather G. Mack, Alexis Ceecee Britten-Jones, Myra B. McGuinness, Fred K. Chen, John R. Grigg, Robyn V. Jamieson, Thomas L. Edwards, John De Roach, Fleur O’Hare, Keith R. Martin, Lauren N. Ayton
Publikováno v:
Gene Therapy. 30:336-346
Many gene therapies are in development for treating people with inherited retinal diseases (IRD). We hypothesized that potential recipients of gene therapy would have knowledge gaps regarding treatment. We aimed to assess knowledge, attitudes, and pe
Publikováno v:
Clinical & Experimental Ophthalmology. 50:768-780
Emerging treatments are being developed for inherited retinal diseases, requiring a clear understanding of natural progression and a database of potential participants for clinical trials. This article describes the rationale, study design and method
Autor:
Alexis Ceecee Britten-Jones, Rui Jin, Lauren N Ayton, Doron G. Hickey, Sena A. Gocuk, Elise Cichello, Fleur O'Hare, Thomas L Edwards
Publikováno v:
Genetics in Medicine. 24:521-534
This study aimed to systematically review and summarize gene therapy treatment for monogenic retinal and optic nerve diseases.This review was prospectively registered (CRD42021229812). A comprehensive literature search was performed in Ovid MEDLINE,
Autor:
Carla J Abbott, Fleur O'Hare, Robert Finger, Jill E Keeffe, Robyn H. Guymer, Chi D Luu, Lauren N Ayton, Sharon A Bentley, Gregory C. Murphy
Publikováno v:
Clinical and Experimental Optometry. 102:506-512
BACKGROUND: As the field of retinal prostheses advances, volunteers are required for device trials, and optimal participant recruitment is vital for intervention success. The aims of this study were: (i) to select tests that assess the psychosocial a
Autor:
Fleur O'Hare, Monica L Hu, Thomas L Edwards, Jiang-Hui Wang, Doron G. Hickey, Zhengyang Liu, Lauren N Ayton
Publikováno v:
Clinicalexperimental optometry. 104(4)
Inherited retinal diseases (IRDs) comprise a heterogeneous group of genetic disorders affecting the retina. Caused by mutations in over 300 genes, IRDs result in visual impairment due to dysfunction and degeneration of photoreceptors, retinal pigment
Autor:
Thomas L Edwards, Zhengyang Liu, Lauren N Ayton, Jiang-Hui Wang, Monica L Hu, Alexis Ceecee Zhang, Fleur O'Hare, Doron G. Hickey
Publikováno v:
Clinicalexperimental optometry. 104(4)
This review presents the phenotypic and genotypic profiles of a select group of inherited retinal diseases (IRDs) that are currently the focus of retinal gene therapy trials globally. Research progress in IRD treatment trials may soon lead to their a
Autor:
Jahan C. Penny-Dimri, Janan Arslan, Alexis Ceecee Britten-Jones, Dev Raveendran, Luke A Perry, Lauren N Ayton, Thomas L Edwards, Zhengyang Liu, Fleur O'Hare, Monica L Hu
Publikováno v:
Acta ophthalmologicaReferences. 100(3)
The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, respec
Autor:
Thomas L Edwards, Jiang-Hui Wang, Janan Arslan, Doron G. Hickey, Fleur O'Hare, Lauren N Ayton, Zhengyang Liu, Fred K. Chen, Andrea L Vincent, Myra B McGuinness, Monica L Hu, Alexander P Noar
Publikováno v:
American journal of ophthalmology. 235
Purpose To evaluate anatomical and functional inter-eye symmetry among individuals with Bietti Crystalline Dystrophy (BCD) using clinical and multi-modal imaging methods, with a focus on the number, area, and distribution of the characteristic retina