Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Fleur M. Ferguson"'
Autor:
Andrew J. Tao, Jiewei Jiang, Gillian E. Gadbois, Pavitra Goyal, Bridget T. Boyle, Elizabeth J. Mumby, Samuel A. Myers, Justin G. English, Fleur M. Ferguson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small
Externí odkaz:
https://doaj.org/article/7e60e12c82e148d7ba52ad726511fade
Autor:
Julien D. F. Licchesi, Heike Laman, Fumiyo Ikeda, Fleur M. Ferguson, Victor M. Bolanos-Garcia
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/5753b43641d5452bace1e9fe38d87aa3
Autor:
M. Catarina Silva, Ghata Nandi, Katherine A. Donovan, Quan Cai, Bethany C. Berry, Radoslaw P. Nowak, Eric S. Fischer, Nathanael S. Gray, Fleur M. Ferguson, Stephen J. Haggarty
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Accumulation of misfolded, aggregating proteins concurrent with disease onset and progression is a hallmark of neurodegenerative proteinopathies. An important class of these are tauopathies, such as frontotemporal dementia (FTD) and Alzheimer’s dis
Externí odkaz:
https://doaj.org/article/fac27ffdbfba46278572b8b29a8d3222
Autor:
Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previou
Externí odkaz:
https://doaj.org/article/459b2972ed404c94bc46191739350a3c
Autor:
Fleur M. Ferguson
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 222-224 (2021)
Externí odkaz:
https://doaj.org/article/5b81e314bbea400e88da850b8106a873
Publikováno v:
Cell Chemical Biology. 30:340-342
Autor:
Fleur M. Ferguson
Publikováno v:
Inducing Targeted Protein Degradation. :205-214
Publikováno v:
Protein Homeostasis in Drug Discovery. :447-464
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Autor:
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Publikováno v:
eLife, Vol 8 (2019)
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but
Externí odkaz:
https://doaj.org/article/61644ae2e0484e5e9ce5e832e02c1ee1
Publikováno v:
Current Protocols. 2
Targeted protein degradation has recently gained widespread interest as both a novel therapeutic strategy and a useful tool in biomedical research. Targeted protein degraders are often sub-stoichiometric and do not require strong binding affinity for