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pro vyhledávání: '"Fleur L. Kidd"'
Autor:
Fleur L. Kidd, Kensuke Futai, Mark F. Bear, Jubin Ryu, Clifford C. Sung, Juli G. Valtschanoff, Tsuyoshi Miyakawa, Albert Y. Hung, Morgan Sheng, Carlo Sala, Mollie A. Woodworth, Richard J. Weinberg
Publikováno v:
The Journal of Neuroscience. 28:1697-1708
Experience-dependent changes in the structure of dendritic spines may contribute to learning and memory. Encoded by three genes, the Shank family of postsynaptic scaffold proteins are abundant and enriched in the postsynaptic density (PSD) of central
Autor:
John T.R. Isaac, Fleur L Kidd
Publikováno v:
Neuropharmacology. 39:725-732
High affinity glutamate transport plays an important role in maintaining a low extracellular glutamate concentration in the CNS. Excitotoxicity due to a loss of glutamate transporter function has been implicated in disease processes such as stroke an
Autor:
John T.R. Isaac, Fleur L Kidd
Publikováno v:
Journal of neurophysiology. 86(3)
Kainate (KA) receptor-mediated excitatory postsynaptic currents (EPSCs) exhibit slow kinetics at the great majority of synapses. However, native or heterologously expressed KA receptors exhibit rapid kinetics in response to agonist application. One p
Autor:
Fleur L Kidd, Graham L. Collingridge, Tim A. Benke, Andreas Lüthi, Fabrice Duprat, Mary J. Palmer, John T.R. Isaac, Jeremy M. Henley, Ramesh Chittajallu
Publikováno v:
Neuron. 24(2)
We investigated whether the interaction between the N-ethyl-maleimide-sensitive fusion protein (NSF) and the AMPA receptor (AMPAR) subunit GluR2 is involved in synaptic plasticity in the CA1 region of the hippocampus. Blockade of the NSF–GluR2 inte
Autor:
John T.R. Isaac, Fleur L Kidd
Publikováno v:
Nature. 400(6744)
Most of the fast excitatory synaptic transmission in the mammalian brain is mediated by ionotrophic glutamate receptors, of which there are three subtypes: AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate), NMDA (N-methyl-D-aspartate) and
Publikováno v:
Neuron. (4):635-646
Previous studies have shown that pharmacological activation of presynaptic kainate receptors at glutamatergic synapses facilitates or depresses transmission in a dose-dependent manner. However, the only synaptically activated kainate autoreceptor des