Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Fleur Elizabeth Tynan"'
Autor:
Rajiv Khanna, Andrew G. Brooks, Stephanie Gras, Lars Kjer-Nielsen, Fleur Elizabeth Tynan, Rebekah M Brennan, John J. Miles, Yu Chih Liu, Zhenjun Chen, Julia K. Archbold, Craig Steven Clements, James McCluskey, Anthony W. Purcell, Denis J. Moss, Travis Clarke Beddoe, Scott R. Burrows, Jamie Rossjohn, Lyudmila Kostenko
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10608-10613
αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear. Despite the current dogma, evaluatio
Autor:
Fleur Elizabeth Tynan, Leanne Cooper, Sharon L. Silins, John J. Miles, Jamie Rossjohn, Zara Jennifer Fulton, Scott R. Burrows, Julia K. Archbold, James McCluskey, Rajiv Khanna, Katherine K Wynn, Stephanie Gras
Publikováno v:
Blood. 111:4283-4292
CD8+ T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive T-cell pool. However, the precise mechanism for this phenomenon remains elusive. Here we show
Autor:
John J. Miles, Fleur Elizabeth Tynan, Scott R. Burrows, Lars Kjer-Nielsen, Natalie A. Borg, Jacqueline M. Burrows, James McCluskey, Rebekah M Brennan, Sharon L. Silins, Melissa J. Bell, Jamie Rossjohn
Publikováno v:
The Journal of Immunology. 177:6804-6814
The underlying generic properties of αβ TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) tha
Autor:
Natalie A. Borg, Sharon L. Silins, Diah Elhassen, Wendy J. van Zuylen, Fleur Elizabeth Tynan, Lars Kjer-Nielsen, John J. Miles, Jamie Rossjohn, Travis Clarke Beddoe, Anthony W. Purcell, Scott R. Burrows, James McCluskey
Publikováno v:
Journal of Biological Chemistry. 280:23900-23909
Although HLA class I alleles can bind epitopes up to 14 amino acids in length, little is known about the immunogenicity or the responding T-cell repertoire against such determinants. Here, we describe an HLA-B*3508-restricted cytotoxic T lymphocyte r
Autor:
Victoria Michelle Adams, Jamie Rossjohn, Isabelle S Lucet, Dena Lyras, Fleur Elizabeth Tynan, Julian I. Rood
Publikováno v:
Journal of Biological Chemistry. 280:2503-2511
Members of the large serine resolvase family of site-specific recombinases are responsible for the movement of several mobile genetic elements; however, little is known regarding the structure or function of these proteins. TnpX is a serine recombina
Autor:
Claude C.A. Bernard, Matthew A. Perugini, Travis Clarke Beddoe, Fleur Elizabeth Tynan, Jamie Rossjohn, Craig Steven Clements, Hugh H. Reid, Terrance Grant Johns
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11059-11064
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. To gain new
Autor:
Fleur Elizabeth Tynan, Lars Kjer-Nielsen, Andrew G. Brooks, James McCluskey, John W. Kappler, Craig Steven Clements, Stephanie Gras, Scott R. Burrows, Anthony W. Purcell, Jamie Rossjohn, Matthew C.J. Wilce, Mandvi Bharadwaj, David C. Jackson, Frances Crawford, W.A. Macdonald, Julia K. Archbold, Philippa M. Saunders, Zhenjun Chen, Brian Stadinsky
Publikováno v:
Immunity. 31(6)
T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the LC13 T cell receptor (TCR), selected for recognition on self-HLA-B( *)0801 bound to a viral peptide, alloreacts with B44 allotypes (HLA-B( *)4402 and HLA-B( *)440
Autor:
John J. Miles, Travis Clarke Beddoe, Scott R. Burrows, Lars Kjer-Nielsen, Jamie Rossjohn, James C. Whisstock, Fleur Elizabeth Tynan, Jacqueline M. Burrows, Anthony W. Purcell, Lyudmila Kostenko, Sharon L. Silins, James McCluskey, Ashley M. Buckle, Craig Steven Clements, Matthew C.J. Wilce, Natalie A. Borg
Publikováno v:
Nature immunology. 6(11)
Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such
Autor:
James McCluskey, Fleur Elizabeth Tynan, Burrows, S. R., Brian Tait, Rhonda Holdsworth, Ashley Maurice Buckle, Frank Christiansen, Craig Steven Clements, Natalie Borg, Travis Clarke Beddoe, James Whisstock, Matthew Charles James Wilce, Silins, Sharon L., Burrows, Jacqueline M., Lars Kjer-Nielsen, Lyudmila Kostenko, Anthony Purcell, Jamie Rossjohn
Publikováno v:
Monash University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a7e25585473121aadb5747dffaf42a7
https://research.monash.edu/en/publications/cf41c7b3-c874-437f-915c-929540acf4fc
https://research.monash.edu/en/publications/cf41c7b3-c874-437f-915c-929540acf4fc
Autor:
Diah Elhassen, Sharon L. Silins, Scott R. Burrows, Fleur Elizabeth Tynan, Jamie Rossjohn, Anthony W. Purcell, Jacqueline M. Burrows, James McCluskey, John J. Miles, Natalie A. Borg, Lars Kjer-Nielsen
Publikováno v:
Monash University
ResearcherID
ResearcherID
MHC class I molecules generally present peptides of 8–10 aa long, forming an extended coil in the HLA cleft. Although longer peptides can also bind to class I molecules, they tend to bulge from the cleft and it is not known whether the TCR repertoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728cf4d4cf244bdc83de2c1c4aa34f57
https://research.monash.edu/en/publications/916f761a-5f83-4624-9f75-7bb9cecef916
https://research.monash.edu/en/publications/916f761a-5f83-4624-9f75-7bb9cecef916