Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fletcher E. Bain"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10274 (2023)
As many as 700,000 unique sequences in the human genome are predicted to fold into G-quadruplexes (G4s), non-canonical structures formed by Hoogsteen guanine–guanine pairing within G-rich nucleic acids. G4s play both physiological and pathological
Externí odkaz:
https://doaj.org/article/ed5a5660b57548d4bab59229ae3771c4
Publikováno v:
Biology, Vol 10, Iss 7, p 571 (2021)
Single-molecule total internal reflection fluorescence (TIRF) microscopy allows for the real-time visualization of macromolecular dynamics and complex assembly. Prism-based TIRF microscopes (prismTIRF) are relatively simple to operate and can be easi
Externí odkaz:
https://doaj.org/article/f1215662bead45bf841227af13a76c12
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10274
As many as 700,000 unique sequences in the human genome are predicted to fold into G-quadruplexes (G4s), non-canonical structures formed by Hoogsteen guanine–guanine pairing within G-rich nucleic acids. G4s play both physiological and pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c91144800b0f071debd6c9cdb1097763
Autor:
Sarah R Hengel, Eva Malacaria, Laura Folly da Silva Constantino, Fletcher E Bain, Andrea Diaz, Brandon G Koch, Liping Yu, Meng Wu, Pietro Pichierri, M Ashley Spies, Maria Spies
Publikováno v:
eLife, Vol 5 (2016)
The DNA repair protein RAD52 is an emerging therapeutic target of high importance for BRCA-deficient tumors. Depletion of RAD52 is synthetically lethal with defects in tumor suppressors BRCA1, BRCA2 and PALB2. RAD52 also participates in the recovery
Externí odkaz:
https://doaj.org/article/1ff0ee6ff1954dba99c56feaf40dcf68
Autor:
Lumir Krejci, Mário Špírek, Fletcher E. Bain, Daniel Nemecek, Sarah R. Hengel, Jana Prochazkova, Liping Yu, Brandon G Koch, Maria Spies, Jarmila Mlcouskova, Barbora Stefanovie, Fedor Nikulenkov
Publikováno v:
Nucleic Acids Research
The proper repair of deleterious DNA lesions such as double strand breaks prevents genomic instability and carcinogenesis. In yeast, the Rad52 protein mediates DSB repair via homologous recombination. In mammalian cells, despite the presence of the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab41112cb530b49c0557d00f25dda16e
https://doi.org/10.1093/nar/gkz1052
https://doi.org/10.1093/nar/gkz1052
Single-molecule total internal reflection fluorescence (TIRF) microscopy allows for real-time visualization of macromolecular dynamics and complex assembly. Prism-based TIRF microscopes (prismTIRF) are relatively simple to operate and can be easily m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702dae5dfa8caeae8a530db0877bfa45
https://doi.org/10.1101/2021.05.10.443430
https://doi.org/10.1101/2021.05.10.443430
Publikováno v:
Biology, Vol 10, Iss 571, p 571 (2021)
Biology
Biology
Simple Summary Prism-based single-molecule total internal reflection fluorescence (prismTIRF) microscopes are excellent tools for studying macromolecular dynamics and interactions. Here, we provide an easy-to-follow guide for the design, assembly, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782be979ab229eb6f380d30c6b3e1fbd
https://doi.org/10.3390/biology10070571
https://doi.org/10.3390/biology10070571
Publikováno v:
Methods in enzymology. 600
Replication protein A (RPA) is a highly conserved, eukaryotic ssDNA-binding protein essential for genome stability. RPA interacts with ssDNA and with protein partners to coordinate DNA replication, repair, and recombination. Single-molecule analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abd25cf2e34b30a66df5b2881503e33f
https://pubmed.ncbi.nlm.nih.gov/29458769
https://pubmed.ncbi.nlm.nih.gov/29458769
Replication protein A (RPA) is a highly conserved, eukaryotic ssDNA-binding protein essential for genome stability. RPA interacts with ssDNA and with protein partners to coordinate DNA replication, repair, and recombination. Single-molecule analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9779a7859114e4acda704fe57e2e90a
https://doi.org/10.1016/bs.mie.2017.11.016
https://doi.org/10.1016/bs.mie.2017.11.016