IKZF3/AIOLOs is associated with but not +sufficient T cells for the expression of IL-10 by CD4:IKZF3 is associated with IL-10+ CD4+ T cells

Autor: Ridley, Michael, Fleskens, Veerle, Roberts, Ceri, Lalnunhlimi, Sylvine, Asnesf, Aldana, O'Byrne, Aoife, Steel, Kathryn, Povoleri, Giovanni, Sumner, Jonathan, Lavender, Paul, Taams, Leonie

Publikováno v: Ridley, M, Fleskens, V, Roberts, C, Lalnunhlimi, S, Asnesf, A, O'Byrne, A, Steel, K, Povoleri, G, Sumner, J, Lavender, P & Taams, L 2020, ' IKZF3/AIOLOs is associated with but not + sufficient T cells for the expression of IL-10 by CD4 : IKZF3 is associated with IL-10+ CD4+ T cells ', Journal of Immunology, vol. 204, no. 11, pp. 2940-2948 . https://doi.org/10.4049/jimmunol.1901283

The expression of anti-inflammatory IL-10 by CD4 + T cells is indispensable for immune homeostasis, as it allows T cells to moderate their effector function. We previously showed that TNF-a blockade during T cell stimulation in CD4 + T cell/monocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::f282b67831d1e9504ffb0bd4219df663
https://kclpure.kcl.ac.uk/en/publications/00b56235-f98e-4336-a4f8-f89c9eaf3391

Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells

Autor: Fleskens, Veerle, Minutti, Carlos M., Wu, Xingmei, Wei, Ping, Pals, Cornelieke E.G.M., McCrae, James, Hemmers, Saskia, Groenewold, Vincent, Vos, Harm Jan, Rudensky, Alexander, Pan, Fan, Li, Huabin, Zaiss, Dietmar M., Coffer, Paul J.

Publikováno v: Fleskens, V, Munoz Minutti, C, Wu, X, Wei, P, Pals, C E G M, McCrae, J, Hemmers, S, Groenewold, V, Vos, H-J, Rudensky, A Y, Pan, F, Li, H, Zaiss, D & Coffer, P J 2019, ' Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells ', Cell Reports, vol. 26, no. 13, pp. 3600-3612 . https://doi.org/10.1016/j.celrep.2019.02.087
Cell Reports
Cell Reports, Vol 26, Iss 13, Pp 3600-3612.e6 (2019)
Cell Reports, 26(13), 3600. Cell Press

Summary The Foxp3 transcription factor is a crucial determinant of both regulatory T (TREG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b6244e07be861bd69117a9fa506f077
https://www.pure.ed.ac.uk/ws/files/81564891/Nemo_like_Kinase_PUB_OA_CC_NC_ND.pdf

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

TNF Blockade Maintains an IL-10⁺ Phenotype in Human Effector CD4⁺ and CD8⁺ T Cells.

Autor: Roberts, Ceri A., Durham, Lucy E., Fleskens, Veerle, Evans, Hayley G., Taams, Leonie S.

Publikováno v: Frontiers in Immunology; 2/15/2017, Vol. 8, p1-14, 14p

Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127^low Treg Cells in Patients With Chronic Rheumatoid Arthritis.

Autor: Walter, Gina J., Fleskens, Veerle, Frederiksen, Klaus S., Rajasekhar, Megha, Menon, Bina, Gerwien, Jens G., Evans, Hayley G., Taams, Leonie S.

Publikováno v: Arthritis & Rheumatology; Jan2016, Vol. 68 Issue 1, p103-116, 14p