Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Flemming Steen, Jørgensen"'
Autor:
Katyayani Sharma, Angelo Lanzilotto, Jibira Yakubu, Søren Therkelsen, Clarissa Daniela Vöegel, Therina Du Toit, Flemming Steen Jørgensen, Amit V. Pandey
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 203 (2024)
Endocrine-disrupting chemicals (EDCs) may impact the development of prostate cancer (PCa) by altering the steroid metabolism. Although their exact mechanism of action in controlling tumor growth is not known, EDCs may inhibit steroidogenic enzymes su
Externí odkaz:
https://doaj.org/article/b28db5315d1941499863869ea0b05810
Autor:
Tomasz M. Wróbel, Katyayani Sharma, Iole Mannella, Simonetta Oliaro-Bosso, Patrycja Nieckarz, Therina Du Toit, Clarissa Daniela Voegel, Maria Natalia Rojas Velazquez, Jibira Yakubu, Anna Matveeva, Søren Therkelsen, Flemming Steen Jørgensen, Amit V. Pandey, Agnese C. Pippione, Marco L. Lolli, Donatella Boschi, Fredrik Björkling
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1349 (2023)
This study reports on the synthesis and evaluation of novel compounds replacing the nitrogen-containing heterocyclic ring on the chemical backbone structure of cytochrome P450 17α-hydroxylase/12,20-lyase (CYP17A1) inhibitors with a phenyl bearing a
Externí odkaz:
https://doaj.org/article/40c682e275f24df7b4e877a00335408d
Autor:
Thiago S. Lima, Luciano O. Souza, Diego Iglesias-Gato, Johanna Elversang, Flemming Steen Jørgensen, Tuula Kallunki, Martin A. Røder, Klaus Brasso, José M.A. Moreira
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Docetaxel (DTX) was the first chemotherapeutic agent to demonstrate significant efficacy in the treatment of men with metastatic castration-resistant prostate cancer. However, response to DTX is generally short-lived, and relapse eventually occurs du
Externí odkaz:
https://doaj.org/article/b1a3ecbd14b041b09850e5e16f85f1fd
Autor:
Simon Bo Jensen, Sara Thodberg, Shaheena Parween, Matias E. Moses, Cecilie C. Hansen, Johannes Thomsen, Magnus B. Sletfjerding, Camilla Knudsen, Rita Del Giudice, Philip M. Lund, Patricia R. Castaño, Yanet G. Bustamante, Maria Natalia Rojas Velazquez, Flemming Steen Jørgensen, Amit V. Pandey, Tomas Laursen, Birger Lindberg Møller, Nikos S. Hatzakis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity tow
Externí odkaz:
https://doaj.org/article/ecd3eccafadb4f149283420e2e8e2cea
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 345-351 (2019)
Aldehyde Oxidase (AO) is an enzyme involved in the metabolism of aldehydes and N-containing heterocyclic compounds. Many drug compounds contain heterocyclic moieties, and AO metabolism has lead to failure of several late-stage drug candidates. Theref
Externí odkaz:
https://doaj.org/article/ec0452d7ce3d4129874d09b1e3f123ea
Autor:
Nanda G. Aduri, Marco Montefiori, Ruqaiya Khalil, Michael Gajhede, Flemming Steen Jørgensen, Osman Mirza
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 2040-2046 (2019)
Externí odkaz:
https://doaj.org/article/ea42543b87494455ab6417647c32a45b
Autor:
Tomasz M. Wróbel, Oksana Rogova, Katyayani Sharma, Maria Natalia Rojas Velazquez, Amit V. Pandey, Flemming Steen Jørgensen, Frederic S. Arendrup, Kasper L. Andersen, Fredrik Björkling
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 165 (2022)
Twenty new compounds, targeting CYP17A1, were synthesized, based on our previous work on a benzimidazole scaffold, and their biological activity evaluated. Inhibition of CYP17A1 is an important modality in the treatment of prostate cancer, which rema
Externí odkaz:
https://doaj.org/article/6056628f75504571a6d1428b90bed8b1
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4237-4244 (2017)
Externí odkaz:
https://doaj.org/article/f8caa28403c8477b8bbed457ebaa9400
Autor:
Nikolai Wulff, Heidi Asschenfeldt Ernst, Morten Egevang Jørgensen, Sophie Lambertz, Tobias Maierhofer, Zeinu Mussa Belew, Christoph Crocoll, Mohammed Saddik Motawia, Dietmar Geiger, Flemming Steen Jørgensen, Osman Mirza, Hussam Hassan Nour-Eldin
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Based on recent in vitro data, a relatively large number of the plant nitrate transporter 1/peptide transporter family (NPF) proteins have been suggested to function as gibberellic acid (GA) transporters. Most GA transporting NPF proteins also appear
Externí odkaz:
https://doaj.org/article/255797cb98d74e8cb3637041b4564a22
Autor:
Karla Frydenvang, Marlies C A Verkade-Vreeker, Floor Dohmen, Jan N M Commandeur, Maria Rafiq, Osman Mirza, Flemming Steen Jørgensen, Daan P Geerke
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217292 (2019)
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as biocatalyst for selective formation of drug metabolites. Hence, molecular and compu
Externí odkaz:
https://doaj.org/article/4ca0b68792244c2ca63e3d37d9ec192e