Zobrazeno 1 - 10 of 70 pro vyhledávání: '"Flemming S. Nielsen"'
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The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
Autor: Rasmus Jorgensen, Luise Gram Schleiss, Kirsten Raun, Jacob Kofoed, Claus Bekker Jeppesen, Birgitte Schjellerup Wulff, Berit Østergaard Christoffersen, Jørgen Olsen, Lars Ynddal, Franziska Zosel, Ulrich Sensfuss, Johan F. Paulsson, Søren Østergaard, Jane Spetzler, Flemming S Nielsen
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070773ae97f4392dec87755c1751435
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
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2
In vitro and in vivo immunogenicity assessment of protein aggregate characteristics
Autor: Camilla Thorlaksen, Heidi S. Schultz, Simon K. Gammelgaard, Wim Jiskoot, Nikos S. Hatzakis, Flemming S. Nielsen, Helene Solberg, Vito Foderà, Christina Bartholdy, Minna Groenning
Publikováno v: Thorlaksen, C, Schultz, H S, Gammelgaard, S K, Jiskoot, W, Hatzakis, N S, Nielsen, F S, Solberg, H, Foderà, V, Bartholdy, C & Groenning, M 2023, ' In vitro and in vivo immunogenicity assessment of protein aggregate characteristics ', International Journal of Pharmaceutics, vol. 631, 122490 . https://doi.org/10.1016/j.ijpharm.2022.122490
International Journal of Pharmaceutics, 631:122490
The immunogenicity risk of therapeutic protein aggregates has been extensively investigated over the past decades. While it is established that not all aggregates are equally immunogenic, the specific aggregate characteristics, which are most likely
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b651b4412052685c98b1342884adc6f
https://pubmed.ncbi.nlm.nih.gov/36521637
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3
Linking Exposure to Polychlorinated Biphenyls With Fatty Fish Consumption and Reduced Fetal Growth Among Danish Pregnant Women: A Cause for Concern?
Autor: Thorhallur I. Halldorsson, Inga Thorsdottir, Sjurdur F. Olsen, Helle Margrete Meltzer, Flemming S Nielsen
Publikováno v: Halldorsson, T I, Thorsdottir, I, Meltzer, H M, Nielsen, F & Olsen, S F 2008, ' Linking Exposure to Polychlorinated Biphenyls With Fatty Fish Consumption and Reduced Fetal Growth Among Danish Pregnant Women : A Cause for Concern? ', American Journal of Epidemiology, vol. 168, no. 8, pp. 958-965 . https://doi.org/10.1093/aje/kwn204
Europe PubMed Central
In a selected group of women from the Danish National Birth Cohort, the authors investigated the association between intake of fatty fish and plasma concentrations of polychlorinated biphenyls (PCBs) on the one hand and the association between matern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb33f24c285211674a593473da613a17
https://doi.org/10.1093/aje/kwn204
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4
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
Autor: Paw Bloch, Jacob Kofoed, Sanne Møller Knudsen, Jane Spetzler, Lotte Bjerre Knudsen, Ingrid Pettersson, Holger M. Strauss, Steffen Reedtz-Runge, Flemming S Nielsen, Thomas Kruse, Kjeld Madsen, Lauge Schäffer, Dorte Bjerre Steensgaard, Jesper Lau, Peter Thygesen, Dorte Xenia Gram, James N. McGuire
Publikováno v: Journal of medicinal chemistry. 58(18)
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb6f7845b12981d7f1d072c2c7a6c7e
https://pubmed.ncbi.nlm.nih.gov/26308095
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5
Left ventricular hypertrophy in normoalbuminuric type 2 diabetic patients not taking antihypertensive treatment
Autor: Flemming S Nielsen, A. Sato, E. Knudsen, L. Tarnow, Hans-Henrik Parving
Publikováno v: QJM: An International Journal of Medicine. 98:879-884
BACKGROUND Left ventricular hypertrophy (LVH) is an independent risk factor for myocardial ischaemia, cardiac arrhythmia, sudden death, and heart failure, all common findings in patients with type 2 diabetes. AIM To determine the prevalence of, and r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b8f95ea39d7d8dec8590a884d7615d
https://doi.org/10.1093/qjmed/hci137
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6
Increased sympathetic activity during sleep and nocturnal hypertension in Type 2 diabetic patients with diabetic nephropathy
Autor: B. Vivien-Roels, Ulla M Smidt, N. J. Christensen, P. Pevet, Peter Karl Jacobsen, Henrik Post Hansen, Hans-Henrik Parving, Peter Rossing, Flemming S Nielsen
Publikováno v: Diabetic Medicine. 16:555-562
Summary Aims To elucidate the putative factors involved in the blunted nocturnal blood pressure reduction in hypertensive Type 2 diabetic patients with diabetic nephropathy. Methods Extracellular fluid volume and fluid shift from interstitial to plas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533027459e37bb861d87f5e641a5e496
https://doi.org/10.1046/j.1464-5491.1999.00127.x
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7
Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study
Autor: Lise Tarnow, Peter Rossing, Hans-Henrik Parving, J Nerup, Thomas Mandrup-Poulsen, Flemming S Nielsen, R Osterby
Publikováno v: Capital Region of Denmark
Scopus-Elsevier
OBJECTIVE: To evaluate kidney function 7 years after the end of treatment with cyclosporine A (CsA) (initial dosage of 9.3 tapered off to 7.0 mg.kg-1.day-1) in young patients (mean age 20 years) with newly diagnosed type 1 diabetes participating in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdbf53963ede23ee300a5a9f56c56ae
https://doi.org/10.2337/diacare.22.3.478
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8
Left Ventricular Hypertrophy in Non-insulin-dependent Diabetic Patients With and Without Diabetic Nephropathy
Autor: M. A. Gall, T. L. Svendsen, L. E. Bang, Hans-Henrik Parving, S. Ali, Flemming S Nielsen, J. Kastrup, Peter Rossing, Ulla M Smidt
Publikováno v: Diabetic Medicine. 14:538-546
The aim of our cross-sectional case-control study was to evaluate putative mechanisms of the increased cardiac morbidity and mortality in NIDDM patients with or without diabetic nephropathy. Fifty-one NIDDM patients with diabetic nephropathy (38 male
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7efbb0cf5b59a1295689ade24dded150
https://doi.org/10.1002/(sici)1096-9136(199707)14:7<538::aid-dia415>3.0.co
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9
Increased Plasma Apolipoprotein(a) Levels in IDDM Patients With Diabetic Nephropathy
Autor: Hans-Henrik Parving, Birgitte V. Hansen, Flemming S Nielsen, Jørn Dyerberg, Lise Tarnow, Peter Rossing
Publikováno v: Diabetes Care. 19:1382-1387
OBJECTIVE The relative mortality from cardiovascular disease (CVD) is increased 40-fold in IDDM patients suffering from diabetic nephropathy as compared with nondiabetic subjects on average. We assessed the potential contribution of dyslipidemia in g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0251b71f611e23be037d6c7839dfcb
https://doi.org/10.2337/diacare.19.12.1382
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