N-acetyl aspartate levels early after ischemic stroke accurately reflect long-term brain damage

Autor: Henrik Hasseldam, Rune Skovgaard Rasmussen, Henrik Hussein El Ali, Flemming Fryd Johansen

Publikováno v: Heliyon, Vol 10, Iss 2, Pp e24233- (2024)

Background: Estimation of brain damage following an ischemic stroke is most often performed within the first few days after the insult, where large amounts of oedematous fluid have accumulated. This can potentially hamper correct measurement of infar

Externí odkaz: https://doaj.org/article/d63beff21a7c46f194bc0e5bd1ae23d9

Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus

Autor: Georg Johannes Müller, Hans Lassmann, Flemming Fryd Johansen

Publikováno v: Neurobiology of Disease, Vol 25, Iss 3, Pp 582-593 (2007)

Several anti-apoptotic proteins are induced in CA1 neurons after transient forebrain ischemia (TFI), but fail to protect the majority of these cells from demise. Correlating cell death morphologies (apoptosis-like and necrosis-like death) with immuno

Externí odkaz: https://doaj.org/article/73bf8c33be5b47fbaaa7ae1515d0b485

Digitalisering af undervisningen i almen patologi

Autor: Ben Vainer, Carina Kirstine Klarskov, Niels Werner Mortensen, Paul Meyer Mai, Flemming Fryd Johansen

Publikováno v: Læring og Medier, Vol 7, Iss 12 (2014)

Patologi er læren om sygdommes manifestationer i væv og celler, herunder sygdommes årsager og mekanismer, og er en central del af undervisningen på en lang række studier om menneskers og dyrs sygdomme. Imod slutningen af 00’erne kom de første

Externí odkaz: https://doaj.org/article/1b6abe2807224838baf2e9068917f00b

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Autor: Ditte Gry Ellman, Seth G. N. Grant, Ellie J. Tuck, Kristian Strømgaard, Bettina Hjelm Clausen, Lotte K. Kristensen, Marc Heitz, Dennis Özcelik, Maksym V. Kopanitsa, Anders Bach, Flemming Fryd Johansen, Pernille B. Lærkegaard Hansen, Henrik Hasseldam, Karin Lykke-Hartmann, Maria Gammelstrup Andersen, Kate Lykke Lambertsen

Publikováno v: Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-Hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150, pp. 100-111 . https://doi.org/10.1016/j.neuropharm.2019.02.035
Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150 . https://doi.org/10.1016/j.neuropharm.2019.02.035

Inhibition of postsynaptic density protein-95 (PSD-95) decouples N-methyl-d-aspartate (NMDA) receptor downstream signaling and results in neuroprotection after focal cerebral ischemia. We have previously developed UCCB01-144, a potent dimeric PSD-95

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaba9b8ffdf9dfc9af46f51cc576309
http://hdl.handle.net/10044/1/68105

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis

Autor: Shohreh Issazadeh-Navikas, Cord Brakebusch, Alba Manresa-Arraut, Flemming Fryd Johansen, Henrik Hasseldam

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Manresa-Arraut, A, Johansen, F F, Brakebusch, C, Issazadeh-Navikas, S & Hasseldam, H 2018, ' RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis ', Frontiers in Immunology, vol. 9, 1235, pp. 1-14 . https://doi.org/10.3389/fimmu.2018.01235

T-cells are known to be intimately involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). T-cell activation is controlled by a range of intracellular signaling pathways regulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005008af8cf6f2733fad7b30b4ea40de
https://doi.org/10.3389/fimmu.2018.01235