N-acetyl aspartate levels early after ischemic stroke accurately reflect long-term brain damage

Autor: Henrik Hasseldam, Rune Skovgaard Rasmussen, Henrik Hussein El Ali, Flemming Fryd Johansen

Publikováno v: Heliyon, Vol 10, Iss 2, Pp e24233- (2024)

Background: Estimation of brain damage following an ischemic stroke is most often performed within the first few days after the insult, where large amounts of oedematous fluid have accumulated. This can potentially hamper correct measurement of infar

Externí odkaz: https://doaj.org/article/d63beff21a7c46f194bc0e5bd1ae23d9

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis

Autor: Alba Manresa-Arraut, Flemming Fryd Johansen, Cord Brakebusch, Shohreh Issazadeh-Navikas, Henrik Hasseldam

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

T-cells are known to be intimately involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). T-cell activation is controlled by a range of intracellular signaling pathways regulating

Externí odkaz: https://doaj.org/article/026acbef7ed748a7bfaf311f9ba1ee89

Turning microscopy in the medical curriculum digital: Experiences from the faculty of health and medical sciences at University of Copenhagen

Autor: Ben Vainer, Niels Werner Mortensen, Steen Seier Poulsen, Allan Have Sørensen, Jørgen Olsen, Hans Henrik Saxild, Flemming Fryd Johansen

Publikováno v: Journal of Pathology Informatics, Vol 8, Iss 1, Pp 11-11 (2017)

Familiarity with the structure and composition of normal tissue and an understanding of the changes that occur during disease is pivotal to the study of the human body. For decades, microscope slides have been central to teaching pathology in medical

Externí odkaz: https://doaj.org/article/5237b8def6254d0ba58ef4856dac1393

Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke

Autor: Oskar McWilliam, Nicole Elisabeth Ørsted Schultz, Flemming Fryd Johansen, Rune Skovgaard Rasmussen, Nina Vindegaard, Helle K. Iversen, Henrik Hasseldam

Publikováno v: Neurological Research. 41:289-297

In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad2ff7e0137e49f33480532c4a7c7fa
https://doi.org/10.1080/01616412.2018.1558000

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Autor: Ditte Gry Ellman, Seth G. N. Grant, Ellie J. Tuck, Kristian Strømgaard, Bettina Hjelm Clausen, Lotte K. Kristensen, Marc Heitz, Dennis Özcelik, Maksym V. Kopanitsa, Anders Bach, Flemming Fryd Johansen, Pernille B. Lærkegaard Hansen, Henrik Hasseldam, Karin Lykke-Hartmann, Maria Gammelstrup Andersen, Kate Lykke Lambertsen

Publikováno v: Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-Hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150, pp. 100-111 . https://doi.org/10.1016/j.neuropharm.2019.02.035
Bach, A, Clausen, B H, Kristensen, L K, Andersen, M G, Ellman, D G, Hansen, P B L, Hasseldam, H, Heitz, M, Özcelik, D, Tuck, E J, Kopanitsa, M V, Grant, S G N, Lykke-hartmann, K, Johansen, F F, Lambertsen, K L & Strømgaard, K 2019, ' Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor ', Neuropharmacology, vol. 150 . https://doi.org/10.1016/j.neuropharm.2019.02.035

Inhibition of postsynaptic density protein-95 (PSD-95) decouples N-methyl-d-aspartate (NMDA) receptor downstream signaling and results in neuroprotection after focal cerebral ischemia. We have previously developed UCCB01-144, a potent dimeric PSD-95

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaba9b8ffdf9dfc9af46f51cc576309
http://hdl.handle.net/10044/1/68105