GGAssembler: Precise and economical design and synthesis of combinatorial mutation libraries.

Autor: Hoch SY; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Netzer R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Weinstein JY; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Krauss L; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Hakeny K; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Oct; Vol. 33 (10), pp. e5169.

Addressing epistasis in the design of protein function.

Autor: Lipsh-Sokolik R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 20; Vol. 121 (34), pp. e2314999121. Date of Electronic Publication: 2024 Aug 12.

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.

Autor: King LDW; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Barrett JR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Davies H; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Quinkert D; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Lias AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Silk SE; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pattinson DJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Diouf A; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Williams BG; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., McHugh K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Rodrigues A; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Rigby CA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Strazza V; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Suurbaar J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra LG 54, Ghana., Rees-Spear C; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK., Dabbs RA; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Ishizuka AS; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Zhou Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Gupta G; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Jin J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Li Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Carnrot C; Novavax AB, Kungsgatan 109, 753 18 Uppsala, Sweden., Minassian AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Campeotto I; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Noe AR; Leidos Life Sciences, Frederick, MD, USA., MacGill RS; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., King CR; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Birkett AJ; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Soisson LA; USAID, 1300 Pennsylvania Avenue NW, Washington, DC 20004, USA., Long CA; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Miura K; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Ashfield R; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Skinner K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Howarth MR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Biswas S; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Draper SJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: simon.draper@bioch.ox.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Jul 16; Vol. 5 (7), pp. 101654.

One-shot design elevates functional expression levels of a voltage-gated potassium channel.

Autor: Weinstein JJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Saikia C; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Karbat I; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Goldenzweig A; Scala Biodesign Ltd, Tel Aviv, Israel., Reuveny E; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Jun; Vol. 33 (6), pp. e4995.

Evolutionary paths that link orthogonal pairs of binding proteins.

Autor: Avizemer Z; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel., Martí-Gómez C; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Hoch SY; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel., McCandlish DM; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.

Publikováno v: Research square [Res Sq] 2023 Dec 13. Date of Electronic Publication: 2023 Dec 13.