Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Autor: Watson, K. A., Chrysina, Evangelia D., Tsitsanou, K. E., Zographos, Spyros E., Archontis, Georgios Z., Fleet, G. W. J., Oikonomakos, Nikos G.

Publikováno v: Proteins: Structure, Function and Genetics
Proteins Struct.Funct.Genet.
Proteins-Structure Function and Bioinformatics 61:4(Dec2005):966-983

Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-β-D-glucopyranosylamine have been identified as the most potent inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cf23ddb56f94bc96851ecd8420c115
https://doi.org/10.1002/prot.20653

The design of potential antidiabetic drugs: Experimental investigation of a number of ?-D-glucose analogue inhibitors of glycogen phosphorylase

Autor: Oikonomakos, Nikos G., Kontou, M., Zographos, Spyros E., Tsitoura, H. S., Johnson, L. N., Watson, K. A., Mitchell, E. P., Fleet, G. W. J., Son, J. C., Bichard, C. J. F., Leonidas, Demetres D., Acharya, K. R.

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics 19:3 185-192

Journal URL: http://www.medhyg.ch/mh/produits/european_journal_of_drug_metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1457::ef52ef33c2258d0ebc5340213e50bf02
http://helios-eie.ekt.gr/EIE/handle/10442/2897

N-Acetyl-Beta-D-Glucopyranosylamine - a Potent T-State Inhibitor of Glycogen-Phosphorylase - a Comparison with Alpha-D-Glucose

Autor: Oikonomakos, Nikos G., Kontou, M., Zographos, Spyros E., Watson, K. A., Johnson, L. N., Bichard, C. J. F., Fleet, G. W. J., Acharya, K. R.

Publikováno v: Protein Science 4:12(Dec1995):2469-2477

Journal URL: http://www.proteinscience.org/; http://www3.interscience.wiley.com/journal/121502357/home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1457::3e1d385f96af9428275a81c253e1786f
http://helios-eie.ekt.gr/EIE/handle/10442/3242

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