Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

Autor: Emary, Katherine R W ^*, Golubchik, Tanya ^*, Aley, Parvinder K, Ariani, Cristina V, Angus, Brian, Bibi, Sagida, Blane, Beth, Bonsall, David, Cicconi, Paola, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Cox, Tony, Darton, Thomas C, Dold, Christina, Douglas, Alexander D, Duncan, Christopher J A, Ewer, Katie J, Flaxman, Amy L, Faust, Saul N, Ferreira, Daniela M, Feng, Shuo, Finn, Adam, Folegatti, Pedro M, Fuskova, Michelle, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hallis, Bassam, Heath, Paul T, Hay, Jodie, Hill, Helen C, Jenkin, Daniel, Kerridge, Simon, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Ludden, Catherine, Marchevsky, Natalie G, Minassian, Angela M, McGregor, Alastair C, Mujadidi, Yama F, Phillips, Daniel J, Plested, Emma, Pollock, Katrina M, Robinson, Hannah, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sutherland, Rebecca K, Thomson, Emma C, Toshner, Mark, Turner, David P J, Vekemans, Johan, Villafana, Tonya L, Williams, Christopher J, Hill, Adrian V S ^*, Lambe, Teresa ^*, Gilbert, Sarah C ^*, Voysey, Merryn ^*, Ramasamy, Maheshi N ^{*, *}, Pollard, Andrew J ^*

Publikováno v: In The Lancet 10-16 April 2021 397(10282):1351-1362

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Autor: Aboagye, Jeremy, Adams, Kelly, Ali, Aabidah, Allen, Elizabeth, Allison, Jennifer L., Anslow, Rachel, Arbe-Barnes, Edward H., Babbage, Gavin, Baillie, Kenneth, Baker, Megan, Baker, Natalie, Baker, Philip, Baleanu, Ioana, Ballaminut, Juliana, Barnes, Eleanor, Barrett, Jordan, Bates, Louise, Batten, Alexander, Beadon, Kirsten, Beckley, Rebecca, Berrie, Eleanor, Berry, Lisa, Beveridge, Amy, Bewley, Kevin R., Bijker, Else Margreet, Bingham, Tracey, Blackwell, Luke, Blundell, Caitlin L., Bolam, Emma, Boland, Elena, Borthwick, Nicola, Bower, Thomas, Boyd, Amy, Brenner, Tanja, Bright, Philip D., Brown-O'Sullivan, Charlie, Brunt, Emily, Burbage, Jamie, Burge, Sharon, Buttigieg, Karen R., Byard, Nicholas, Cabera Puig, Ingrid, Calvert, Anna, Camara, Susana, Cao, Michelangelo, Cappuccini, Federica, Carr, Melanie, Carroll, Miles W., Carter, Victoria, Cathie, Katrina, Challis, Ruth J., Charlton, Sue, Chelysheva, Irina, Cho, Jee-Sun, Cicconi, Paola, Cifuentes, Liliana, Clark, Helen, Clark, Elizabeth, Cole, Tom, Colin-Jones, Rachel, Conlon, Christopher P., Cook, Aislinn, Coombes, Naomi S., Cooper, Rachel, Cosgrove, Catherine A., Coy, Karen, Crocker, Wendy E.M., Cunningham, Christina J., Damratoski, Brad E., Dando, Lynne, Datoo, Mehreen S., Davies, Hannah, De Graaf, Hans, Demissie, Tesfaye, Di Maso, Claudio, Dietrich, Isabelle, Dong, Tao, Donnellan, Francesca R., Douglas, Naomi, Downing, Charlotte, Drake, Jonathan, Drake-Brockman, Rachael, Drury, Ruth Elizabeth, Dunachie, Susanna Jane, Edwards, Nick J., Edwards, Frances D.L., Edwards, Chris J., Elias, Sean C., Elmore, Michael J., Emary, Katherine R.W., English, Marcus Rex, Fagerbrink, Susanne, Felle, Sally, Feng, Shuo, Field, Samantha, Fixmer, Carine, Fletcher, Clare, Ford, Karen J., Fowler, Jamie, Fox, Polly, Francis, Emma, Frater, John, Furze, Julie, Fuskova, Michelle, Galiza, Eva, Gbesemete, Diane, Gilbride, Ciaran, Godwin, Kerry, Gorini, Giacomo, Goulston, Lyndsey, Grabau, Caroline, Gracie, Lara, Gray, Zoe, Guthrie, Lucy Belle, Hackett, Mark, Halwe, Sandro, Hamilton, Elizabeth, Hamlyn, Joseph, Hanumunthadu, Brama, Harding, Irasha, Harris, Stephanie A., Harris, Andrew, Harrison, Daisy, Harrison, Clare, Hart, Thomas C., Haskell, Louise, Hawkins, Sophia, Head, Ian, Henry, John Aaron, Hill, Jennifer, Hodgson, Susanne H.C., Hou, Mimi M., Howe, Elizabeth, Howell, Nicola, Hutlin, Cecilia, Ikram, Sabina, Isitt, Catherine, Iveson, Poppy, Jackson, Susan, Jackson, Frederic, James, Sir William, Jenkins, Megan, Jones, Elizabeth, Jones, Kathryn, Jones, Christine E., Jones, Bryony, Kailath, Reshma, Karampatsas, Konstantinos, Keen, Jade, Kelly, Sarah, Kelly, Dearbhla, Kerr, David, Kerridge, Simon, Khan, Liaquat, Khan, Uzma, Killen, Annabel, Kinch, Jasmin, King, Thomas B., King, Lloyd, King, Jade, Kingham-Page, Lucy, Klenerman, Paul, Knapper, Francesca, Knight, Julian C., Knott, Daniel, Koleva, Stanislava, Kupke, Alexandra, Larkworthy, Colin W., Larwood, Jessica P.J., Laskey, Anna, Lawrie, Alison M., Lee, Arlene, Ngan Lee, Kim Yee, Lees, Emily A, Legge, Helen, Lelliott, Alice, Lemm, Nana-Marie, Lias, Amelia M., Linder, Aline, Lipworth, Samuel, Liu, Xinxue, Liu, Shuchang, Lopez Ramon, Raquel, Lwin, May, Mabesa, Francesca, Madhavan, Meera, Mallett, Garry, Mansatta, Kushal, Marcal, Ines, Marinou, Spyridoula, Marlow, Emma, Marshall, Julia L., Martin, Jane, McEwan, Joanne, McInroy, Lorna, Meddaugh, Gretchen, Mentzer, Alexander J., Mirtorabi, Neginsadat, Moore, Maria, Moran, Edward, Morey, Ella, Morgan, Victoria, Morris, Susan Jane, Morrison, Hazel, Morshead, Gertraud, Morter, Richard, Mujadidi, Yama F., Muller, Jilly, Munera-Huertas, Tatiana, Munro, Claire, Munro, Alasdair, Murphy, Sarah, Munster, Vincent J., Mweu, Philomena, Noé, Andrés, Nugent, Fay L., Nuthall, Elizabeth, O'Brien, Katie, O'Connor, Daniel, Oguti, Blanché, Oliver, Jennifer L., Oliveira, Catarina, O'Reilly, Peter John, Osborn, Mairead, Osborne, Piper, Owen, Cathy, Owens, Daniel, Owino, Nelly, Pacurar, Mihaela, Parker, Kaye, Parracho, Helena, Patrick-Smith, Maia, Payne, Victoria, Pearce, Jennifer, Peng, Yanchun, Peralta Alvarez, Marco Polo, Perring, James, Pfafferott, Katja, Pipini, Dimitra, Plested, Emma, Pluess-Hall, Helen, Pollock, Katrina, Poulton, Ian, Presland, Laura, Provstgaard-Morys, Samuel, Pulido, David, Radia, Kajal, Ramos Lopez, Fernando, Rand, Jade, Ratcliffe, Helen, Rawlinson, Thomas, Rhead, Sarah, Riddell, Amy, Ritchie, Adam John, Roberts, Hannah, Robson, Joanna, Roche, Sophie, Rohde, Cornelius, Rollier, Christine S., Romani, Rossana, Rudiansyah, Indra, Saich, Stephen, Sajjad, Sara, Salvador, Stephannie, Sanchez Riera, Lidia, Sanders, Helen, Sanders, Katherine, Sapaun, Shari, Sayce, Chloe, Schofield, Ella, Screaton, Gavin, Selby, Beatrice, Semple, Calum, Sharpe, Hannah R., Shaik, Imam, Shea, Adam, Shelton, Holly, Silk, Sarah, Silva-Reyes, Laura, Skelly, Donal T., Smee, Heather, Smith, Catherine C., Smith, David J., Song, Rinn, Spencer, Alexandra J., Stafford, Elizabeth, Steele, Amy, Stefanova, Elena, Stockdale, Lisa, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tait, Moira, Talbot, Helen, Tanner, Rachel, Taylor, Iona Jennifer, Taylor, Victoria, Te Water Naude, Rebecca, Thakur, Nazia, Themistocleous, Yrene, Themistocleous, Andreas, Thomas, Merin, Thomas, Tonia M., Thompson, Amber, Thomson-Hill, Samantha, Tomlins, Jennifer, Tonks, Susan, Towner, James, Tran, Nguyen, Tree, Julia A., Truby, Adam, Turkentine, Kate, Turner, Cheryl, Turner, Nicola, Turner, Sally, Tuthill, Toby, Ulaszewska, Marta, Varughese, Rachel, Van Doremalen, Neeltje, Veighey, Kristin, Verheul, Marije K., Vichos, Iason, Vitale, Elia, Walker, Laura, Watson, Marion E.E., Welham, Benjamin, Wheat, Julie, White, Caroline, White, Rachel, Worth, Andrew T., Wright, Danny, Wright, Suzie, Yao, Xin Li, Yau, Yasmine, Folegatti, Pedro M ^*, Ewer, Katie J ^*, Aley, Parvinder K, Angus, Brian, Becker, Stephan, Belij-Rammerstorfer, Sandra, Bellamy, Duncan, Bibi, Sagida, Bittaye, Mustapha, Clutterbuck, Elizabeth A, Dold, Christina, Faust, Saul N, Finn, Adam, Flaxman, Amy L, Hallis, Bassam, Heath, Paul, Jenkin, Daniel, Lazarus, Rajeka, Makinson, Rebecca, Minassian, Angela M, Pollock, Katrina M, Ramasamy, Maheshi, Robinson, Hannah, Snape, Matthew, Tarrant, Richard, Voysey, Merryn, Green, Catherine ^*, Douglas, Alexander D ^*, Hill, Adrian V S ^*, Lambe, Teresa ^*, Gilbert, Sarah C ^*, Pollard, Andrew J ^{*, *}

Publikováno v: In The Lancet 15-21 August 2020 396(10249):467-478

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 VOC 202012/01 (B.1.1.7), an exploratory analysis of a randomised controlled trial

Autor: Emary, Katherine RW, Golubchik, Tanya, Aley, Parvinder K, Ariani, Cristina V, Angus, Brian, Bibi, Sagida, Blane, Beth, Bonsall, David, Cicconi, Paola, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Cox, Tony, Darton, Thomas C, Dold, Christina, Douglas, Alexander D, Duncan, Christopher JA, Ewer, Katie J, Flaxman, Amy L, Faust, Saul N, Ferreir, Daniela M, Feng, Shuo, Finn, Adam, Folegatti, Pedro M, Fuskova, Michelle, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hallis, Bassam, Heath, Paul T, Hay, Jodie, Hill, Helen C, Jenkin, Daniel, Kerridge, Simon, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Ludden, Catherine, Marchevsky, Natalie G, Minassian, Angela M, McGregor, Alastair C, Mujadidi, Yama F, Phillips, Daniel J, Plested, Emma, Pollock, Katrina M, Robinson, Hannah, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sutherland, Rebecca K, Thomson, Emma C, Toshner, Mark, Turner, David PJ, Vekemans, Johan, Villafana, Tonya L, Williams, Christopher J, Hill, Adrian VS, Lambe, Teresa, Gilbert, Sarah C, Voysey, Merryn, Ramasamy, Maheshi N, Pollard, Andrew J, Consortium, The COVID-19 Genomics UK, Project, The AMPHEUS, Group, The Oxford COVID-19 Vaccine Trial

A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the United Kingdom from November 2020. Here we report efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19, against this variant.
COVID-19 Genomics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3360959dbc170b036cee90bdf148f3eb

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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial.

Autor: Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: maheshi.ramasamy@paediatrics.ox.ac.uk., Minassian AM; The Jenner Institute, University of Oxford, Oxford, UK., Ewer KJ; The Jenner Institute, University of Oxford, Oxford, UK., Flaxman AL; The Jenner Institute, University of Oxford, Oxford, UK., Folegatti PM; The Jenner Institute, University of Oxford, Oxford, UK., Owens DR; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Angus B; The Jenner Institute, University of Oxford, Oxford, UK., Babbage G; The Jenner Institute, University of Oxford, Oxford, UK., Belij-Rammerstorfer S; The Jenner Institute, University of Oxford, Oxford, UK., Berry L; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Bittaye M; The Jenner Institute, University of Oxford, Oxford, UK., Cathie K; Paediatric Medicine, University of Southampton, Southampton, UK., Chappell H; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Charlton S; National Infection Service, Public Health England, Porton Down, Salisbury, UK., Cicconi P; The Jenner Institute, University of Oxford, Oxford, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Colin-Jones R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Emary KRW; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Fedosyuk S; The Jenner Institute, University of Oxford, Oxford, UK., Fuskova M; The Jenner Institute, University of Oxford, Oxford, UK., Gbesemete D; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Green C; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Hallis B; National Infection Service, Public Health England, Porton Down, Salisbury, UK., Hou MM; The Jenner Institute, University of Oxford, Oxford, UK., Jenkin D; The Jenner Institute, University of Oxford, Oxford, UK., Joe CCD; The Jenner Institute, University of Oxford, Oxford, UK., Kelly EJ; AstraZeneca BioPharmaceuticals Research and Development, Washington, DC, USA., Kerridge S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Lawrie AM; The Jenner Institute, University of Oxford, Oxford, UK., Lelliott A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Lwin MN; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Makinson R; The Jenner Institute, University of Oxford, Oxford, UK., Marchevsky NG; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Mujadidi Y; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Munro APS; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Pacurar M; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Plested E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Rand J; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Rawlinson T; The Jenner Institute, University of Oxford, Oxford, UK., Rhead S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Robinson H; Nuffield Department of Medicine, and Oxford Centre for Clinical Tropical Medicine and Global Health, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Ritchie AJ; The Jenner Institute, University of Oxford, Oxford, UK., Ross-Russell AL; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Saich S; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Singh N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Smith CC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Song R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Tarrant R; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Themistocleous Y; The Jenner Institute, University of Oxford, Oxford, UK., Thomas KM; National Infection Service, Public Health England, Porton Down, Salisbury, UK., Villafana TL; AstraZeneca BioPharmaceuticals Research and Development, Bethesda, MA, USA., Warren SC; NIHR Clinical Research Facility, University Hospital Southampton NHS Trust, Southampton, UK., Watson MEE; The Jenner Institute, University of Oxford, Oxford, UK., Douglas AD; The Jenner Institute, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Hill AVS; The Jenner Institute, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Lambe T; The Jenner Institute, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Gilbert SC; The Jenner Institute, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Trust and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.

Publikováno v: Lancet (London, England) [Lancet] 2021 Dec 19; Vol. 396 (10267), pp. 1979-1993. Date of Electronic Publication: 2020 Nov 19.