Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Flaviu Gruia"'
Autor:
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://doaj.org/article/c7112dc536a744a789e3b298aa48181d
Autor:
Flaviu Gruia, Andrew C. Nyborg, Manuel Baca, Arun Parupudi, Jared S. Bee, Richard L. Remmele, Chris Ward
Publikováno v:
Journal of Pharmaceutical Sciences. 106:1018-1024
This study explores the structural and functional changes associated with a low-temperature thermal transition of 2 engineered bacterial uricase mutants. Uricase has a noncovalent homotetrameric structure, with 4 active sites located at the interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bcb385cc46dfa6d614bbf730b97c72
https://doi.org/10.1016/j.xphs.2016.12.028
https://doi.org/10.1016/j.xphs.2016.12.028
Autor:
Kuldip Sra, Flaviu Gruia, Sonia Dragulin-Otto, Samuel A. Korman, Jared S. Bee, Richard L. Remmele, Arun Parupudi
Publikováno v:
Journal of virological methods. 247
Antigenic drift of the influenza A virus requires that vaccine production is targeted to the strains circulating each year. Live-attenuated influenza A vaccine manufacturing is used to produce intact virions with the surface antigens of the circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3c29912aa8121ce7ba9c8fee451f3c
https://pubmed.ncbi.nlm.nih.gov/28601563
https://pubmed.ncbi.nlm.nih.gov/28601563
Publikováno v:
Analytical Chemistry. 86:6850-6857
We describe the characterization of degradation products responsible for color change in near UV-visible light-irradiated and heat-stressed monoclonal antibody (mAb) drug product in liquid formulation. The treated samples were characterized using rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7beb540541f2a1a64da9cab361155781
https://doi.org/10.1021/ac404218t
https://doi.org/10.1021/ac404218t
Autor:
Philip Brohawn, Sunjay Kaushal, Sudhish Sharma, Sotirios Karanthasis, Grace Bigham, Flaviu Gruia, Rachana Mishra
Publikováno v:
Circulation Research. 119
Background: Human cardiac progenitor cells (hCPCs), identified by ckit + /CD45 - , provide a promising therapeutic option following myocardial infarction (MI) as their clinical relevance has been validated in the S tem C ell I nfusion in P atients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e962234a33cb0c6b0f8afa2db5dd9a7
https://doi.org/10.1161/res.119.suppl_1.209
https://doi.org/10.1161/res.119.suppl_1.209
Autor:
Minoru Kubo, Flaviu Gruia, Estelle M. Maes, Paul M. Champion, William R. Montfort, Abdelkrim Benabbas, Alexander Barabanschikov
Publikováno v:
Journal of the American Chemical Society. 130:9800-9811
The low-frequency mode activity of metalloporphyrins has been studied for iron porphine-halides (Fe(P)(X), X = Cl, Br) and nitrophorin 4 (NP4) using femtosecond coherence spectroscopy (FCS) in combination with polarized resonance Raman spectroscopy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102936ae0d0bee2d8f8cd1cdcb66dfda
https://doi.org/10.1021/ja800916d
https://doi.org/10.1021/ja800916d
Autor:
Minoru Kubo, Xiong Ye, Flaviu Gruia, Changyuan Lu, Paul M. Champion, Syun Ru Yeh, Robert K. Poole, Dan Ionascu
Publikováno v:
Journal of the American Chemical Society. 130:5231-5244
Femtosecond coherence spectroscopy is used to probe the low-frequency (20-200 cm(-1)) vibrational modes of heme proteins in solution. Horseradish peroxidase (HRP), myoglobin (Mb), and Campylobacter jejuni globin (Cgb) are compared and significant dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0250ac6b2853d2a06ea1ad29bec8e20f
https://doi.org/10.1021/ja7104027
https://doi.org/10.1021/ja7104027
Publikováno v:
Biophysical Journal. 94(6):2252-2268
Femtosecond coherence spectroscopy is applied to a series of ferric heme protein samples. The low-frequency vibrational spectra that are revealed show dominant oscillations near 40 cm(-1). MbCN is taken as a typical example of a histidine-ligated, si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa5aef9d2e99261c2554812abe14bb
Publikováno v:
PDA journal of pharmaceutical science and technology. 69(3)
Nanoparticle Tracking Analysis (NTA) is an emerging analytical technique developed for detection, sizing, and counting of sub-micron particles in liquid media. Its feasibility for use in biopharmaceutical development was evaluated with particle stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70384a8bc9ad810425f177de0cad3aa
https://pubmed.ncbi.nlm.nih.gov/26048748
https://pubmed.ncbi.nlm.nih.gov/26048748
Autor:
John S. Olson, Dan Ionascu, Christopher Beck, Xiong Ye, Andrey Demidov, Anchi Yu, Florin Rosca, Paul M. Champion, Flaviu Gruia
Publikováno v:
Journal of the American Chemical Society. 127:16921-16934
The rebinding kinetics of NO to the heme iron of myoglobin (Mb) is investigated as a function of temperature. Below 200 K, the transition-state enthalpy barrier associated with the fastest (approximately 10 ps) recombination phase is found to be zero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f081eacfa1b7395be7403ce050dab
https://doi.org/10.1021/ja054249y
https://doi.org/10.1021/ja054249y