Výsledky vyhledávání - "Flavio S. J. de Souza"

Conserved roles of Rax/rx3 genes in hypothalamus and pituitary development

Autor: Flavio S. J. de Souza, Marysia Placzek

Publikováno v: The International Journal of Developmental Biology. 65:195-205

Rax (Rx) genes encode paired-type homeodomain-containing transcription factors present in virtually all metazoan groups. In vertebrates, studies in fish, amphibian, chick and mouse models have revealed that these genes play important roles in the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e822f17e0c8cd60b2935030a318ca581
https://doi.org/10.1387/ijdb.200081fd

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The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and ActivatesPomcExpression in the Developing Hypothalamus

Autor: Sofia Nasif, Daniela Paula Orquera, Flavio S. J. de Souza, Marcelo Rubinstein, M. Belén Tavella, Malcolm J. Low

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Food intake is tightly regulated by a group of neurons present in the arcuate nucleus of the hypothalamus, which release Pomc-encoded melanocortins, the absence of which induces marked hyperphagia and early-onset obesity. Although the relevance of hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c830620b2d8960b80d11d393792a1f64
https://doi.org/10.1523/jneurosci.2924-18.2019

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Are neutrophil extracellular traps the link for the cross-talk between periodontitis and rheumatoid arthritis physiopathology?

Autor: Tarcília Aparecida Silva, Ayda Henriques Schneider, Gilda Aparecida Ferreira, Jôice Dias Corrêa, Sicília Rezende Oliveira, Mário Taba Júnior, Valessa Florindo Carvalho, José Alcides Almeida de Arruda, Letícia Fernanda Duffles, Flavio S. J. de Souza, Fernando Q. Cunha, Lucas Guimarães Abreu, Paulo Louzada-Junior, Caio Cavalcante Machado, Renê Donizeti Ribeiro de Oliveira, Fernando Oliveira Costa, Sandra Y. Fukada, Marcela Faria Moura

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objectives Neutrophil extracellular traps (NETs) play a role in the pathogenesis of periodontitis and rheumatoid arthritis (RA). However, it remains poorly understood whether NETs participate in the cross-talk between periodontitis and RA. Herein, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed67281c7c0e8ab18e4a5575da2d2b8
https://pubmed.ncbi.nlm.nih.gov/33752229

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Rathke’s cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors

Autor: Flavio S. J. de Souza, Hironori Bando, Adriana Carla Camarano, Sally A. Camper, Shingo Fujio, Michelle L. Brinkmeier, Koji Yoshimoto

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Clin Invest

The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gonadotrope lineages. Pituitary-specific Isl1 deletion causes hypopituitarism with increased stem cell apoptosis, reduced differentiation of thyrotropes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1aaaee4288fa0bd2cd97e4d07c82f7
https://www.jci.org/articles/view/136745

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SAT-042 Pituitary Expression Of Isl1 Prevents Ectopic, Foxa1 And Foxj1 Mediated Differentiation Of Progenitors Into Rathke’S Cleft Cysts

Autor: Koji Yashimoto, Shingo Fujio, Flavio S. J. de Souza, Hironori Bando, Sally A. Camper, Adriana Camarano, Michelle L. Brinkmeier

Publikováno v: Journal of the Endocrine Society

Islet 1 (ISL1) is a LIM homeodomain transcription factor expressed in the developing pituitary gland. Its expression overlaps with the progenitor markers SOX2 and PROP1 and with the differentiation markers NR5A1 and CGA, or alpha-subunit. We conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e504633f2774114f820aaa34141a0b
http://europepmc.org/articles/PMC6551927

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The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates

Autor: Daniela P, Orquera, M Belén, Tavella, Flavio S J, de Souza, Sofía, Nasif, Malcolm J, Low, Marcelo, Rubinstein

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(21)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff789f6d09f8d3245ca988aa3c07ab30
https://pubmed.ncbi.nlm.nih.gov/30886014

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Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?

Autor: Lucía F. Franchini, Flavio S. J. de Souza, Marcelo Rubinstein

Publikováno v: Molecular Biology and Evolution

Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have been particularly effective in colonizing mammalian genomes, and such heavy TE load is expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05815f6efa4cecc0481365f4c0863a3
https://doi.org/10.1093/molbev/mst045

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Sequencing of small RNAs of the fern Pleopeltis minima (Polypodiaceae) offers insight into the evolution of the microRNA repertoire in land plants

Autor: Flavio S. J. de Souza, Mercedes Rivero, Leandro Julián Martínez Tosar, Florencia Berruezo, Pablo Picca, Alicia M. Zelada, Sergio I. Nemirovsky, Alejandro Mentaberry

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177573 (2017)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE

MicroRNAs (miRNAs) are short, single stranded RNA molecules that regulate the stability and translation of messenger RNAs in diverse eukaryotic groups. Several miRNA genes are of ancient origin and have been maintained in the genomes of animal and pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4030ff97801ef9384ad4b89f914df518

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Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus

Autor: Daniela Paula Orquera, Sofia Nasif, Flavio S. J. de Souza, Marcelo Rubinstein, Malcolm J. Low

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The hypothalamus is a region of the anterior forebrain that controls basic aspects of vertebrate physiology, but the genes involved in its development are still poorly understood. Here, we investigate the function of the homeobox gene Rax/Rx in early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10fbe0b0e9d5e8da9a5207546d9cac2
https://europepmc.org/articles/PMC4961556/

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