Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Flavio Leoni"'
Autor:
Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni, Christian Steinkühler
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract Background In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF-β binding protein family, emerged as an important predictor of functional outcome trajectories in mice and hum
Externí odkaz:
https://doaj.org/article/0f356416b1154c7383749c0960a74fa8
Autor:
Theodora Chlapanidas, Sara Perteghella, Flavio Leoni, Silvio Faragò, Mario Marazzi, Daniela Rossi, Emanuela Martino, Raffaella Gaggeri, Simona Collina
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 8, Pp 13624-13636 (2014)
This study aims to evaluate the effect of combined use of the racemic flavanone Naringenin (NRG) and the protein sericin as TNF-α blockers. Sericin (SMs) and (R/S) NRG-loaded Sericin (SNRGMs) microparticles were prepared by spray-drying, characteriz
Externí odkaz:
https://doaj.org/article/19ac8681afe349fe9558192e43ea7cae
Autor:
Silvia Consalvi, Chiara Mozzetta, Paolo Bettica, Massimiliano Germani, Francesco Fiorentini, Francesca Del Bene, Maurizio Rocchetti, Flavio Leoni, Valmen Monzani, Paolo Mascagni, Pier Lorenzo Puri, Valentina Saccone
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 79-87 (2013)
Abstract Previous work has established the existence of dystrophin-nitric oxide (NO) signaling to histone deacetylases (HDACs) that is deregulated in dystrophic muscles. As such, pharmacological interventions that target HDACs (that is, HDAC inhibito
Externí odkaz:
https://doaj.org/article/228636ca172f4dd983eb3ef54f6caf4d
Autor:
Simona Collina, Ornella Azzolina, Daniele Passarella, Flavio Leoni, Raffaella Gaggeri, Michael S. Christodoulou, Daniela Rossi
Publikováno v:
Molecules, Vol 17, Iss 2, Pp 1665-1674 (2012)
Phytochemical investigation on the Amygdalus lycioides Spach branchelets resulted in the isolation of four chiral flavanones: (2R,3R)-Taxifolin, (2R,3R)-aromadendrin, (S)-5,7,3',5'-tetrahydroxyflavanone and (S)-naringenin. The flavanones were isolate
Externí odkaz:
https://doaj.org/article/f517398d567e41799256c555e1cf8b47
Autor:
Paolo Pagani, Andrea Stevenazzi, Christian Steinkühler, Maria Lattanzio, Sandrone Giovanni, Giulia Porro, Raffaella Perego, Elisabetta Galbiati, Paola Cordella, Ripamonti Chiara, Gianluca Fossati, Barbara Vergani, Pezzuto Marcello, Flavio Leoni, Gianluca Caprini, Pavich Gianfranco, Daniela Modena, Edoardo Cellupica, M. Skorupska, Pietro Pozzi, Ilaria Rocchio, Roberta Pomarico, Mattia Marchini
Publikováno v:
Journal of medicinal chemistry. 62(23)
Histone deacetylase 6 (HDAC6) is a peculiar HDAC isoform whose expression and functional alterations have been correlated with a variety of pathologies such as autoimmune disorders, neurodegenerative diseases, and cancer. It is primarily a cytoplasmi
Autor:
Roberto Maggio, Francesca Megiorni, Giuliana Porro, Alessandro Fanzani, Ilaria Pietrantoni, Vincenzo Tombolini, Giovanni Luca Gravina, Francesco Marampon, Silvia Codenotti, Alfredo Budillon, Elisabetta Galbiati, Claudio Festuccia, Pietro Pozzi, Flavio Leoni, L. Ferella, Paolo Mascagni, Andrea Mancini
Publikováno v:
Journal of cancer research and clinical oncology. 145(2)
Aberrant expression and activity of histone deacetylases (HDACs) sustain glioblastoma (GBM) onset and progression, and, therefore, HDAC inhibitors (HDACi) represent a promising class of anti-tumor agents. Here, we analyzed the effects of ITF2357 (giv
Autor:
Francesco Marampon, Flavio Leoni, Andrea Mancini, Ilaria Pietrantoni, Silvia Codenotti, Letizia Ferella, Francesca Megiorni, Giuliana Porro, Elisabetta Galbiati, Pietro Pozzi, Paolo Mascagni, Alfredo Budillon, Roberto Maggio, Vincenzo Tombolini, Alessandro Fanzani, Giovanni Luca Gravina, Claudio Festuccia
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 145:2411-2411
In the original publication, the 6th author's first name and the last name was inverted and incorrectly published. The correct author name is Letizia Ferella.
Autor:
Flavio Leoni, Valmen Monzani, Charles A. Dinarello, Antonio Furlan, Daniela Modena, Leonid L. Reznikov, Paolo Mascagni, Gianluca Fossati
Publikováno v:
Molecular Medicine, 17, 353-62
Molecular Medicine, 17, 5-6, pp. 353-62
Molecular Medicine, 17, 5-6, pp. 353-62
Contains fulltext : 97219.pdf (Publisher’s version ) (Open Access) ITF2357 (givinostat) is a histone deacetylase inhibitor with antiinflammatory properties at low nanomolar concentrations. We report here a phase I safety and pharmacokinetics trial
Autor:
Narges Hajikarimian, Daniela Rossi, Francesco Bracco, Raffaella Gaggeri, Simona Collina, Flavio Leoni, Emanuela Martino, Cesare Dacarro, Ornella Azzolina, Gabriele Mascheroni, Pietro Grisoli
Publikováno v:
The Open Natural Products Journal. 3:20-25
Badam Talkh kuhi is an endemic species of Iran commonly used by native people as anti-inflammatory and an- timicrobial remedy. The present study was aimed at investigating the folk claims of this plant, identified by us as Amygdalus lycioides Spach.
Autor:
Tania Azam, Paolo Mascagni, Gianluca Fossati, Silvano Sozzani, Pietro Pozzi, Britta Siegmund, Giamila Fantuzzi, Giancarlo Dona, Pomerantz Benjamin, Andrea Zaliani, Philip Bufler, Giorgio Bertolini, Flavio Leoni, Leonid L. Reznikov, Giulia Porro, Igor Goncharov, Charles A. Dinarello, Paolo Pagani, Soo-Hyun Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 99:2995-3000
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and inhibits the activity of histone deacetylase. Although SAHA, like other inhibitors of histone deacetylase, exhibits antitumor