Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Flavio Di Pisa"'
Autor:
Flavio Di Pisa, Stefano De Benedetti, Enrico Mario Alessandro Fassi, Mauro Bombaci, Renata Grifantini, Angelo Musicò, Roberto Frigerio, Angela Pontillo, Cinzia Rigo, Sandra Abelli, Romualdo Grande, Nadia Zanchetta, Davide Mileto, Alessandro Mancon, Alberto Rizzo, Alessandro Gori, Marina Cretich, Giorgio Colombo, Martino Bolognesi, Louise Jane Gourlay
Publikováno v:
Vaccines, Vol 10, Iss 1, p 71 (2022)
Chagas disease (CD) is a vector-borne parasitosis, caused by the protozoan parasite Trypanosoma cruzi, that affects millions of people worldwide. Although endemic in South America, CD is emerging throughout the world due to climate change and increas
Externí odkaz:
https://doaj.org/article/3254ae672fc54ec1b58f7ebdf0acafb0
Autor:
Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1246 (2021)
Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatment
Externí odkaz:
https://doaj.org/article/dea8a1bafe16424b8a3fa4033cb94bf8
Autor:
Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
Externí odkaz:
https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394
Autor:
Stefano De Benedetti, Flavio Di Pisa, Enrico Mario Alessandro Fassi, Marina Cretich, Angelo Musicò, Roberto Frigerio, Alessandro Mussida, Mauro Bombaci, Renata Grifantini, Giorgio Colombo, Martino Bolognesi, Romualdo Grande, Nadia Zanchetta, Maria Rita Gismondo, Davide Mileto, Alessandro Mancon, Louise Jane Gourlay
Publikováno v:
Vaccines, Vol 9, Iss 4, p 322 (2021)
The human parasitic disease Schistosomiasis is caused by the Schistosoma trematode flatworm that infects freshwaters in tropical regions of the world, particularly in Sub-Saharan Africa, South America, and the Far-East. It has also been observed as a
Externí odkaz:
https://doaj.org/article/292b4e96110142fbae1f20fd88fddf3c
Autor:
Ina Pöhner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-da-Silva, Maria P. Costi, Alberto Venturelli, Rebecca C. Wade
Publikováno v:
Journal of Medicinal Chemistry. 65:9011-9033
The optimization of compounds with multiple targets is a difficult multidimensional problem in the drug discovery cycle. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e41398a9a37d40ed6cd866693989d0d
https://doi.org/10.1021/acs.jmedchem.2c00232
https://doi.org/10.1021/acs.jmedchem.2c00232
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 78(Pt 4)
Pteridine reductase 1 (PTR1) is a key enzyme of the folate pathway in protozoan parasites of the genera Leishmania and Trypanosoma and is a valuable drug target for tropical diseases. This enzyme is able to catalyze the NADPH-dependent reduction of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecbc47e8a7f2334ea6292fd84f73e0fb
https://pubmed.ncbi.nlm.nih.gov/35400669
https://pubmed.ncbi.nlm.nih.gov/35400669
Pteridine reductase 1 (PTR1) is a key enzyme of the folate pathway in protozoan parasites of the genera Leishmania and Trypanosoma and is a valuable drug target for tropical diseases. This enzyme is able to catalyze the NADPH-dependent reduction of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336d05aec8fd4d19d8fb70a11d413169
https://hdl.handle.net/11365/1228235
https://hdl.handle.net/11365/1228235
Autor:
Costi, Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola
Publikováno v:
Pharmaceuticals; Volume 14; Issue 12; Pages: 1246
Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9f37c247ef65ec81955c73e3737fb064
Autor:
Maria Kuzikov, G. Landi, Maria Paola Costi, Nuno Santarém, Antonio Quotadamo, Cecilia Pozzi, Ina Poehner, Bernhard Ellinger, Lucia Dello Iacono, Joanna Panecka-Hofman, Stefano Mangani, Matteo Santucci, Rebecca C. Wade, Anabela Cordeiro-da-Silva, Sheraz Gul, Pasquale Linciano, Flavio Di Pisa, Rosaria Luciani, Gesa Witt, Alberto Venturelli
The optimization of compounds with multiple targets in the drug discovery cycle is a difficult multidimensional problem. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Efficient mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4b5e1556ad24e83bd22e30049ded70
https://doi.org/10.33774/chemrxiv-2021-9fpln-v3
https://doi.org/10.33774/chemrxiv-2021-9fpln-v3
Autor:
Flavio Di Pisa, Andrea Pinto, Marco Rabuffetti, Martina Letizia Contente, Andrés R. Alcántara, Louise J. Gourlay, Pietro Cannazza, Francesco Molinari, Diego Romano, Pilar Hoyos, Ivano Eberini, T. Laurenzi
Publikováno v:
Bioorganic chemistry. 108
Benzil reductases are dehydrogenases preferentially active on aromatic 1,2-diketones, but the reasons for this peculiar substrate recognition have not yet been clarified. The benzil reductase (KRED1-Pglu) from the non-conventional yeast Pichia glucoz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e463f661f5472a7bf3247ebdfd18b0
https://pubmed.ncbi.nlm.nih.gov/33486371
https://pubmed.ncbi.nlm.nih.gov/33486371