Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Flavio A. R. Barbosa"'
Autor:
Giancarlo V. Botteselle, Welman C. Elias, Luana Bettanin, Rômulo F. S. Canto, Drielly N. O. Salin, Flavio A. R. Barbosa, Sumbal Saba, Hugo Gallardo, Gianluca Ciancaleoni, Josiel B. Domingos, Jamal Rafique, Antonio L. Braga
Publikováno v:
Molecules, Vol 26, Iss 15, p 4446 (2021)
Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-ni
Externí odkaz:
https://doaj.org/article/5ed3b569fb7744dbb50e46937ac87b9c
Autor:
Ruth L. Quispe, Michael L. Jaramillo, Ingrid A. V. Wolin, Rômulo F. S. Canto, Flavio A. R. Barbosa, Antônio L. Braga, João B. T. Rocha, Michael Aschner, Rodrigo B. Leal, Andreza F. de Bem, Marcelo Farina
Publikováno v:
Neurotoxicity Research. 40:127-139
Autor:
Rômulo Farias Santos Canto, Caroline Brandão Quines, Juliano B. Azeredo, Flávia Suelen de Oliveira Pereira, Cristiane Lucchese, Simone Pinton, Flavio A. R. Barbosa, Daiana Silva Ávila, Antonio L. Braga
Publikováno v:
NeuroToxicology. 88:14-24
In a previous in vitro study, dihydropyrimidinone-derived selenoesteres demonstrated antioxidant properties, metal chelators and inhibitory acetylcholinesterase (AChE) activity, making these compounds promising candidates for Alzheimer’s Disease (A
Autor:
Luana Candice Genz Bazana, Theo V. C. Russo, Alexandre Meneghello Fuentefria, William Lopes, Marcus M. Sá, Mário Lettieri Teixeira, Ânderson Ramos Carvalho, Rômulo F. S. Canto, Flavio A. R. Barbosa, Luís Flávio Souza de Oliveira, Marilene Henning Vainstein, Gustavo Pozza Silveira
Publikováno v:
ChemistrySelect. 5:10495-10500
Autor:
Aline Aita Naime, Rafaela Rafognatto Andreguetti, Marcelo Farina, Partha Narayan Dey, Viviane de Souza, Flavio A. R. Barbosa, Diones Caeran Bueno, Axel Methner, Antonio L. Braga, Rômulo Faria Santos Canto, Mark William Lopes, Verena Wüllner
Publikováno v:
Molecular Neurobiology. 57:3273-3290
Probucol, a hypocholesterolemic compound, is neuroprotective in several models of neurodegenerative diseases but has serious adverse effects in vivo. We now describe the design and synthesis of two new probucol analogues that protect against glutamat
Autor:
Ruth L, Quispe, Michael L, Jaramillo, Ingrid A V, Wolin, Rômulo F S, Canto, Flavio A R, Barbosa, Antônio L, Braga, João B T, Rocha, Michael, Aschner, Rodrigo B, Leal, Andreza F, de Bem, Marcelo, Farina
Publikováno v:
Neurotoxicity research. 40(1)
Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant whose mechanisms of action involve oxidation of endogenous nucleophilic groups (mainly thiols and selenols), depletion of antioxidant defenses, and disruption of neurotransmitter homeos
Autor:
Rozangela Curi Pedrosa, Danilo Wilhelm Filho, Antonio L. Braga, Jean Carlo Benassi, Graziâni Candiotto, Flavio A. R. Barbosa, Valdelúcia M.A.S. Grinevicius
Publikováno v:
Journal of biomolecular structuredynamics. 40(18)
Dihydropyrimidinones have demonstrated different biological activities including anticancer properties. Cytotoxic potential and antiproliferative potential of new dihydropyrimidinone-derived selenoesters (Se-DHPM) compounds were assessed
Autor:
Fabiana Ourique, Antonio L. Braga, Gabriela M. Almeida, Rômulo Faria Santos Canto, Nádia S.R.S. Mota, Flavio A. R. Barbosa, Rozangela Curi Pedrosa, Tâmila Siminski
Publikováno v:
European Journal of Medicinal Chemistry. 155:503-515
Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and selectivity for tumour cells. Three analogues of 3j were designed and syn
Autor:
Andreza Fabro de Bem, Antonio L. Braga, Flavio A. R. Barbosa, Ruth Liliám Quispe, Michael L. Jaramillo, Rômulo Faria Santos Canto, Marcelo Farina
Publikováno v:
Molecular Neurobiology. 55:7619-7634
Recent studies have shown that probucol (PB), a hipocholesterolemic agent with antioxidant and anti-inflammatory properties, presents neuroprotective properties. On the other hand, adverse effects have limited PB's clinical application. Thus, the sea
Autor:
Theo V. C. Russo, Taís Fernanda Andrzejewski Kaminski, Alexandre Meneghello Fuentefria, Flavio A. R. Barbosa, Michel Mansur Machado, Gustavo Pozza Silveira, Marilene Henning Vainstein, Antonio L. Braga, William Lopes, Rômulo Faria Santos Canto, Marcus M. Sá, Misael Ferreira, Luís Flávio Souza de Oliveira, Mário Lettieri Teixeira, Saulo Fernandes de Andrade, Bruna Gerardon Batista, Daiane Flores Dalla Lana
Publikováno v:
ChemistrySelect. 2:11926-11932