Lithothamnion muelleri treatment ameliorates inflammatory and hypernociceptive responses in antigen-induced arthritis in mice.

Autor: Vivian V Costa, Flavio A Amaral, Fernanda M Coelho, Celso M Queiroz-Junior, Bruna G Malagoli, Jose Hugo S Gomes, Fernando Lopes, Kátia D Silveira, Daniela Sachs, Caio T Fagundes, Lívia D Tavares, Vanessa Pinho, Tarcilia A Silva, Mauro M Teixeira, Fernão C Braga, Danielle G Souza

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118356 (2015)

Rheumatoid Arthritis (RA) is a chronic disease characterized by persistent inflammation and pain. Alternative therapies to reduce these symptoms are needed. Marine algae are valuable sources of diverse bioactive compounds. Lithothamnion muelleri (Hap

Externí odkaz: https://doaj.org/article/4b9a41d8598a46bd963941bb348a56f3

S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity

Autor: Sergio C. Oliveira, Mariana T.Q. de Magalhães, Duana C. dos S. Astoni, Bruno P. Santos, Amanda D. Braga, Suellen B. Morais, Rafaela Salgado Ferreira, Enrico G. T. Gimenez, Flavio A Amaral, Fábio S. Mambelli

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009007 (2021)

The Schistosoma mansoni SmKI-1 protein is composed of two domains: a Kunitz-type serine protease inhibitor motif (KD) and a C-terminus domain with no similarity outside the genera. Our previous work has demonstrated that KD plays an essential role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fcec6740bf1e93207a39efed961250
http://europepmc.org/articles/PMC7846107

CXCR2 is critical for bacterial control and development of joint damage and pain inStaphylococcus aureus-induced septic arthritis in mouse

Autor: Waldiceu A. Verri, Vivian Louise Soares de Oliveira, Paul Proost, Daiane Boff, Flavio A Amaral, Tarcília Aparecida Silva, Celso Martins Queiroz Junior, Marcelo Allegretti, Mauro M. Teixeira

Publikováno v: European Journal of Immunology. 48:454-463

Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4891188af099ca71aabe13196c774a5
https://doi.org/10.1002/eji.201747198

THE KALLIKREIN-KININ SYSTEM IS FALLING INTO PIECES: BRADYKININ FRAGMENTS ARE BIOLOGICAL ACTIVE PEPTIDES

Autor: Jarbas M. Resende, Vivian Louise Soares de Oliveira, Isabella Domingos da Rocha, Maísa Mota Antunes, Sérgio Ricardo Aluotto Scalzo Júnior, Gustavo B. Menezes, Silvia Guatimosim, Thiago Verano-Braga, Robson A.S. Santos, Lídia Pereira B. Cordeiro, Cristiane Amorim de Paula, Anderson K. Santos, Vanessa P. Teixeira, Marco Antônio Peliky Fontes, Flavio A Amaral, Igor Maciel Souza-Silva

Publikováno v: Souza-Silva, I M, Paula, C, Santos, A, Oliveira, V, Rocha, I, Antunes, M, Cordeiro, L, Teixeira, V, Scalzo-Junior, S, Amaral, F, Resende, J, Fontes, M A, Menezes, G, Guatimosim, S, Santos, R & Verano-Braga, T 2021, ' THE KALLIKREIN-KININ SYSTEM IS FALLING INTO PIECES: BRADYKININ FRAGMENTS ARE BIOLOGICAL ACTIVE PEPTIDES ', Journal of Hypertension, vol. 39, no. Suppl. 1, pp. E256 . https://doi.org/10.1097/01.hjh.0000747380.40105.8d

Background and purposeBradykinin [BK-(1-9)] is an endogenous peptide involved in many physiological and pathological processes, such as cardiovascular homeostasis and inflammation. The central dogma of the kallikrein-kinin system is that BK-(1-9) fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297de28d6d0fbeaf33a19b472c7f177
https://doi.org/10.1097/01.hjh.0000747380.40105.8d

A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis

Autor: Vera Lúcia dos Santos, Flavia Rodrigues da Silva, Carolina Nunes da Silva, Maria Elena de Lima, Armando da Silva Cunha Júnior, Pablo Victor Mendes Dos Reis, Bruna Lopes da Costa, Rummenigge Oliveira Silva, Paula Santos Nunes, Lays Fernanda Nunes Dourado, Flavio A Amaral

Publikováno v: Toxins
Volume 11
Issue 4
Toxins, Vol 11, Iss 4, p 203 (2019)

Bacterial keratitis is an ocular infection that can lead to severe visual disability. Staphylococcus aureus is a major pathogen of the eye. We recently demonstrated the strong antimicrobial activity of LyeTxI-b, a synthetic peptide derived from a Lyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e840812e789de6adb5f734f1ad56d1
https://doi.org/10.3390/toxins11040203