Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Flavio, Vincenti"'
Autor:
Christian P. Larsen, MD, PhD, Flavio Vincenti, MD, Tzuyung D. Kou, PhD, MPH, MA, Craig A. Shadur, MD, Barbara Bresnahan, MD, Stanley C. Jordan, MD, E. Steve Woodle, MD, Nelson Goes, MD, John Vella, MD, David Wojciechowski, DO, Martin S. Polinsky, MD, Andres Gomez-Caminero, PhD, MPH
Publikováno v:
Transplantation Direct, Vol 10, Iss 6, p e1644 (2024)
Background. Belatacept, a selective T-cell costimulation blocker, was associated with improved survival and renal function but also with a risk of posttransplant lymphoproliferative disorder (PTLD) in adult kidney transplant recipients in phase 3 tri
Externí odkaz:
https://doaj.org/article/2074e66814974bf6b1f527406f52b6fd
Autor:
Meixue Duan, Doan C. Nguyen, Chester J. Joyner, Celia L. Saney, Christopher M. Tipton, Joel Andrews, Sagar Lonial, Caroline Kim, Ian Hentenaar, Astrid Kosters, Eliver Ghosn, Annette Jackson, Stuart Knechtle, Stalinraja Maruthamuthu, Sindhu Chandran, Tom Martin, Raja Rajalingam, Flavio Vincenti, Cynthia Breeden, Ignacio Sanz, Greg Gibson, F. Eun-Hyung Lee
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112682- (2023)
Summary: Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adult
Externí odkaz:
https://doaj.org/article/e2cfa9f8c92144a5ae6fadda3ba129f7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Nephrotic syndrome (NS) is a clinical entity characterized by proteinuria, hypoalbuminemia, and peripheral edema. NS affects about 2–7 per 100,000 children aged below 18 years old yearly and is classified, based on the response to drugs, into stero
Externí odkaz:
https://doaj.org/article/78b46f6c4daf4ff494f52ae51601a293
Autor:
Cary M. Looney, MS, Aaron Schroeder, BS, Erica Tavares, BSN, Jay Garg, MD, MBA, Thomas Schindler, PhD, Flavio Vincenti, MD, Robert R. Redfield, MD, Stanley C. Jordan, MD, Stephan Busque, MD, E. Steve Woodle, MD, Jared Khan, MS, Jeffrey Eastham, MS, Sandrine Micallef, PhD, Cary D. Austin, MD, PhD, Alyssa Morimoto, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 2, p e1436 (2023)
Background. The THEORY study evaluated the effects of single and multiple doses of obinutuzumab, a type 2 anti-CD20 antibody that induces antibody-dependent cell-mediated cytotoxicity and direct cell death, in combination with standard of care in pat
Externí odkaz:
https://doaj.org/article/10259b2ed34f4a58b4712c88b2dfd5e4
Publikováno v:
Kidney International Reports, Vol 6, Iss 2, Pp 296-303 (2021)
Introduction: One-third of kidney transplantation patients experience acute kidney injury (AKI) resulting in delayed graft function (DGF), associated with increased risk of graft failure and mortality. Preclinical and phase 2 data indicate that treat
Externí odkaz:
https://doaj.org/article/aaee112e0a95436f9ddc1e7f720b3801
Autor:
Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases, however, the impact of inflammation on Tregs remains controversial. We challenged human Tregs ex-vivo with pro-inflammatory cytokines IL-6 and TNFα and ob
Externí odkaz:
https://doaj.org/article/5cdfcab8b4bf4ad796a6f97fd9b9fa78
Autor:
Alexandre Loupy, Olivier Aubert, Gillian Divard, Christophe Legendre, Julio Pascual, Claudia Sommerer, Federico Oppenheimer, Franco Citterio, Helio Tedesco, Steve Chadban, Mitchell Henry, Flavio Vincenti, Titte Srinivas, Yoshihiko Watarai, Peter Bernhardt
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
Objectives Development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We applied a validated integrative risk-prognostication system integrative Box (iBox) as a surrogate endpoint to the TRANSFORM S
Externí odkaz:
https://doaj.org/article/a7070933a5104b9d94f837a1dc93cc94
Autor:
Silvia Pineda, Tara K. Sigdel, Juliane M. Liberto, Flavio Vincenti, Marina Sirota, Minnie M. Sarwal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, tha
Externí odkaz:
https://doaj.org/article/08b11559921a47c3bbc1810bb121763c
Autor:
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Alloreactive regulatory T cells (arTregs) are more potent than polyclonal Tregs at suppressing immune responses to transplant antigens. Human arTregs can be expanded with allogeneic CD40L-stimulated B cells (sBcs) or stimulated-matured monocyte-deriv
Externí odkaz:
https://doaj.org/article/9d418a90dcc64e0eb0b0d4191628aa1e
Autor:
Arya Zarinsefat, George Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio Vincenti, Chun J. Yee, Minnie M. Sarwal
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
COVID-19 has posed a significant threat to global health. Early data has revealed that IL-6, a key regulatory cytokine, plays an important role in the cytokine storm of COVID-19. Multiple trials are therefore looking at the effects of Tocilizumab, an
Externí odkaz:
https://doaj.org/article/3ee169dd4d724d3ca6bf4ec925b76bdc