Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Flavio, Salazar Onfray"'
Autor:
Francisco Rodas, Jetzabel A. Vidal-Vidal, Daniela Herrera, David A. Brown-Brown, Diego Vera, Joaquín Veliz, Pilar Püschel, José I. Erices, Verónica Sánchez Hinojosa, Julio C. Tapia, Eduardo Silva-Pavez, Claudia Quezada-Monrás, Pablo Mendoza-Soto, Flavio Salazar-Onfray, Cristian Carrasco, Ignacio Niechi
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Gallbladder cancer (GBC) is a prevalent and deadly biliary tract carcinoma, often diagnosed at advanced stages with limited treatment options. The 5-year survival rate varies widely from 4 to 60%, mainly due to differences in dise
Externí odkaz:
https://doaj.org/article/dbab4179d4a748d7bef2277a241ba50f
Autor:
Ernesto Lopez, Sofía Hidalgo, Eduardo Roa, Javiera Gómez, Carlos Hermansen Truan, Evy Sanders, Cristian Carrasco, Rodrigo Pacheco, Flavio Salazar-Onfray, Manuel Varas-Godoy, Vincenzo Borgna, Alvaro Lladser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTGallbladder cancer (GBC) is commonly diagnosed at late stages when conventional treatments achieve only modest clinical benefit. Therefore, effective treatments for advanced GBC are needed. In this context, the administration of T cells genet
Externí odkaz:
https://doaj.org/article/7c7a9ee9f63e4479b9438a5cddb061e2
Autor:
Andrés Tittarelli, Cristian Pereda, María A. Gleisner, Mercedes N. López, Iván Flores, Fabián Tempio, Alvaro Lladser, Adnane Achour, Fermín E. González, Claudia Durán-Aniotz, Juan P. Miranda, Milton Larrondo, Flavio Salazar-Onfray
Publikováno v:
Vaccines, Vol 12, Iss 4, p 357 (2024)
Cancer vaccines present a promising avenue for treating immune checkpoint blockers (ICBs)-refractory patients, fostering immune responses to modulate the tumor microenvironment. We revisit a phase I/II trial using Tumor Antigen-Presenting Cells (TAPC
Externí odkaz:
https://doaj.org/article/de619fa28af44adebdfdd1e2b4a8fc4d
Autor:
Paulina García-González, Fabián Tempio, Camila Fuentes, Consuelo Merino, Leonardo Vargas, Valeska Simon, Mirliana Ramirez-Pereira, Verónica Rojas, Eduardo Tobar, Glauben Landskron, Juan Pablo Araya, Mariela Navarrete, Carla Bastias, Rocío Tordecilla, Macarena A. Varas, Pablo Maturana, Andrés E. Marcoleta, Miguel L. Allende, Rodrigo Naves, Marcela A. Hermoso, Flavio Salazar-Onfray, Mercedes Lopez, María Rosa Bono, Fabiola Osorio
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The prognosis of severe COVID-19 patients has motivated research communities to uncover mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed to understand the immunological dynamics of severe COVID-19 patients with d
Externí odkaz:
https://doaj.org/article/b7c3d75c9db846c59e3e718bd204c58b
Autor:
José-Dellis Rocha, Daniel Uribe, Javiera Delgado, Ignacio Niechi, Sebastián Alarcón, José Ignacio Erices, Rómulo Melo, Rodrigo Fernández-Gajardo, Flavio Salazar-Onfray, Rody San Martín, Claudia Quezada Monrás
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9022 (2022)
Glioblastoma is the most common and aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation that persists under hypoxic niches, called glioblastoma stem-like cells (GSCs). The chemoresistance
Externí odkaz:
https://doaj.org/article/5dfddc43e2704698ade033fd7cb97f90
Autor:
Alfredo Torres, Sheilah Vivanco, Francisca Lavín, Cristián Pereda, Alexey Chernobrovkin, Alejandra Gleisner, Marcela Alcota, Milton Larrondo, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev, Fermín E. González
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6882 (2022)
Damage-associated molecular patterns (DAMPs) play a critical role in dendritic cells (DCs) ability to trigger a specific and efficient adaptive immune response for different physiological and pathological scenarios. We have previously identified cons
Externí odkaz:
https://doaj.org/article/7e0bad66ea694f18b489823bfdadbd70
Autor:
Pedro Briceño, Elizabeth Rivas-Yañez, Mariana V. Rosemblatt, Brian Parra-Tello, Paula Farías, Leonardo Vargas, Valeska Simon, César Cárdenas, Alvaro Lladser, Flavio Salazar-Onfray, Alvaro A. Elorza, Mario Rosemblatt, María Rosa Bono, Daniela Sauma
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown that within the CD8+ T cell
Externí odkaz:
https://doaj.org/article/ae1c7e0583f64dbba7e19f373c99c234
Autor:
Flavio Salazar Onfray
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/8bc406cc09a942d2bafd7cfce9c86a75
Autor:
María Alejandra Gleisner, Cristián Pereda, Andrés Tittarelli, Mariela Navarrete, Camila Fuentes, Ignacio Ávalos, Fabian Tempio, Juan Pablo Araya, María Inés Becker, Fermín Eduardo González, Mercedes Natalia López, Flavio Salazar-Onfray
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of complementary immunothera
Externí odkaz:
https://doaj.org/article/28c908f8ce38455c8c9cfa54e97678c0
Autor:
Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe, Flavio Salazar-Onfray
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only effective treatment, and
Externí odkaz:
https://doaj.org/article/124a4fc0cd004b6992db791e2209fd5b