Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Flavien Bermont"'
1
Akademický článek
Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites
Autor: Nina Criado Santos, Samuel Bouvet, Maria Cruz Cobo, Marion Mandavit, Flavien Bermont, Cyril Castelbou, Farah Mansour, Maral Azam, Francesca Giordano, Paula Nunes-Hasler
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Phagosome maturation is critical for immune defense, defining whether ingested material is destroyed or converted into antigens. Sec22b regulates phagosome maturation, yet how has remained unclear. Here we show Sec22b tethers endoplasmic ret
Externí odkaz: https://doaj.org/article/ee9a3e08071a4a0d9d719efac957cca9
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2
Akademický článek
The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state
Autor: Anna Weiser, Aurélie Hermant, Flavien Bermont, Federico Sizzano, Sonia Karaz, Pilar Alvarez-Illera, Jaime Santo-Domingo, Vincenzo Sorrentino, Jerome N. Feige, Umberto De Marchi
Publikováno v: Redox Biology, Vol 64, Iss , Pp 102759- (2023)
Regulation of mitochondrial redox balance is emerging as a key event for cell signaling in both physiological and pathological conditions. However, the link between the mitochondrial redox state and the modulation of these conditions remains poorly d
Externí odkaz: https://doaj.org/article/a579efc55ff94776a164adcc0e5fb71f
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3
Akademický článek
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
Autor: Paula Nunes-Hasler, Sophia Maschalidi, Carla Lippens, Cyril Castelbou, Samuel Bouvet, Daniele Guido, Flavien Bermont, Esen Y. Bassoy, Nicolas Page, Doron Merkler, Stéphanie Hugues, Denis Martinvalet, Bénédicte Manoury, Nicolas Demaurex
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and
Externí odkaz: https://doaj.org/article/d16f804a8f3d4c7abd46394836e7b3e1
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4
Akademický článek
Human myogenic reserve cells are quiescent stem cells that contribute to muscle regeneration after intramuscular transplantation in immunodeficient mice
Autor: Thomas Laumonier, Flavien Bermont, Pierre Hoffmeyer, Vincent Kindler, Jacques Menetrey
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Satellite cells, localized within muscles in vivo, are Pax7+ muscle stem cells supporting skeletal muscle growth and regeneration. Unfortunately, their amplification in vitro, required for their therapeutic use, is associated with reduced re
Externí odkaz: https://doaj.org/article/e755f377ea2047b689cf6de97f099a2c
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6
The SNARE Sec22b regulates phagosome maturation by promoting ORP8-mediated PI(4)P exchange at ER-phagosome contact sites
Autor: Nina Criado Santos, Samuel Bouvet, Flavien Bermont, Cyril Castelbou, Farah Mansour, Maral Azam, Francesca Giordano, Paula Nunes-Hasler
The precise control of phagosome maturation is critical for innate and adaptive immunity, determining whether phagocytosed material is destroyed or used to present antigens. We observed previously that non-fusogenic contacts between the endoplasmic r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81107b1cc2c023389c99606091cc8493
https://doi.org/10.1101/2022.04.12.487993
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7
Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells
Autor: Aurelie Hermant, Marine R.-C. Kraus, Flavien Bermont, Jaime Santo-Domingo, Christian Chabert, Romy Benninga, Umberto De Marchi, Jerome N. Feige, Guillaume Jacot
Publikováno v: Nutrients
Nutrients, Vol 12, Iss 2, p 538 (2020)
Volume 12
Issue 2
Pancreatic &beta
cells secrete insulin to lower blood glucose, following a meal. Maintenance of &beta
cell function is essential to preventing type 2 diabetes. In pancreatic &beta
cells, mitochondrial matrix calcium is an activating si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9e6fc42f23b0d9b311791cff116dbd
https://pubmed.ncbi.nlm.nih.gov/32093050
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8
The plant product quinic acid activates Ca(2+)‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells
Autor: Jaime Santo-Domingo, Flavien Bermont, Eija Heikkilä, Sameer S. Kulkarni, Aurelie Hermant, Carles Cantó, Umberto De Marchi, Andreas Wiederkehr, Denis Barron, Jonathan Thevenet, Joanna Ratajczak, Elhadji M. Dioum
Publikováno v: Br J Pharmacol
BACKGROUND AND PURPOSE: Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta‐cell functions, which contribute to the contro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a28962a8025bb33221e8ca105b40d3
https://europepmc.org/articles/PMC6692587/
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9
Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin-secreting cells
Autor: Aurelie Hermant, Martin Kussmann, Steve Lassueur, Jaime Santo Domingo, Andreas Wiederkehr, Umberto De Marchi, Jonathan Thevenet, Loïc Dayon, Flavien Bermont, Antonio Núñez Galindo
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4)
In pancreatic β-cells, mitochondria generate signals that promote insulin granule exocytosis. Here we study how lysine acetylation of mitochondrial proteins mechanistically affects metabolism-secretion coupling in insulin-secreting cells. Using mass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3579d43c7d1c6a06c4c4dde7ae08a8
https://pubmed.ncbi.nlm.nih.gov/30589571
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10
STIM1 promotes migration, phagosomal maturation and antigen cross presentation in dendritic cells
Autor: Doron Merkler, Nicolas Page, Stéphanie Hugues, Sophia Maschalidi, Bénédicte Manoury, Esen Yonca Bassoy, Carla Lippens, Samuel Bouvet, Nicolas Demaurex, Cyril Castelbou, Paula Nunes-Hasler, Flavien Bermont, Denis Martinvalet, Daniele Guido
Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01600-6⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol. 8, No 1 (2017) P. 1852
Antigen cross-presentation by dendritic cells (DC) stimulates cytotoxic T cell activation to promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens generate potent T cell responses, but the signalling and trafficking p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9240f7ad501e7f7671c504fecb8b871
https://hal.archives-ouvertes.fr/hal-03103708/document
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