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Autor:
Dalia Simona Miron, Victor Voicu, Adrian C. Nicolescu, Mihaela Ionescu, Flavian Ştefan Rădulescu, Constantin Mircioiu
Publikováno v:
Toxicology Letters. 219:99-106
Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d0a6998d61eb07b3815ebba1cee270
https://doi.org/10.1016/j.toxlet.2013.03.005
https://doi.org/10.1016/j.toxlet.2013.03.005
Publikováno v:
International journal of pharmaceutics. 509(1-2)
Both biopharmaceutics classification system (BCS) and topical drug classification system (TCS) are based on sound scientific principles with the aim of providing biowaiver and reducing regulatory burden without lowering the quality requirements and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cffb8528a2b6c90b6be4d8e8b5a9270
https://pubmed.ncbi.nlm.nih.gov/27208656
https://pubmed.ncbi.nlm.nih.gov/27208656
Publikováno v:
European Neuropsychopharmacology. 22:319-329
The metabolic processes frequently trigger highly complex pharmacokinetic (PK) and pharmacodynamic (PD) characteristics for the coexisting entities, parent drug and its active or inactive metabolites. The interpretation of both individual and cumulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2fea5207a4e186a774eea77ea883bd
https://doi.org/10.1016/j.euroneuro.2011.08.004
https://doi.org/10.1016/j.euroneuro.2011.08.004
Publikováno v:
Journal of Applied Toxicology. 30:719-729
Undoubtedly, the use of oximes represents real progress in counteracting intoxications with organophosphates (OP), through potentiating antidotal effects of atropine. The penetration extent of these compounds through the blood-brain barrier (BBB) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c914bacb1565dacab7dd3dcf4478f2b3
https://doi.org/10.1002/jat.1561
https://doi.org/10.1002/jat.1561
Publikováno v:
Acta Endocrinologica (Bucharest). 6:265-285
The pharmacokinetic characteristics of a compound as well as the immediate consequences of its physicochemical behavior during interactions with biological structures, represent the key issues for its pharmacodynamic profile, starting from the most f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b4b0beadd7908332f7c73167eb0559
https://doi.org/10.4183/aeb.2010.265
https://doi.org/10.4183/aeb.2010.265
Publikováno v:
International journal of pharmaceutics. 491(1-2)
The Biopharmaceutics Classification System (BCS) for oral immediate release solid drug products has been very successful; its implementation in drug industry and regulatory approval has shown significant progress. This has been the case primarily bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25e94bf99625576ab1f6139ef169b17
https://pubmed.ncbi.nlm.nih.gov/26070249
https://pubmed.ncbi.nlm.nih.gov/26070249
Publikováno v:
Expert opinion on drug metabolismtoxicology. 11(1)
The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83ac312aa5c829346df6a8ae6c54814
https://pubmed.ncbi.nlm.nih.gov/25373357
https://pubmed.ncbi.nlm.nih.gov/25373357
Publikováno v:
Pharmaceutical development and technology. 19(2)
Two 1% and one 0.75% metronidazole cream products were approved as bioequivalent products. These products were evaluated for their in vivo cutaneous penetration characteristics by dermatopharmacokinetic (DPK) and dermal microdialysis (DMD) sampling m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6deeac1992cdc7b29af7f52f817b77b
https://pubmed.ncbi.nlm.nih.gov/23360505
https://pubmed.ncbi.nlm.nih.gov/23360505
Publikováno v:
Expert opinion on drug metabolismtoxicology. 9(1)
The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. Establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1f2160d9532539ed4bcc10a7e14f32
https://pubmed.ncbi.nlm.nih.gov/23176543
https://pubmed.ncbi.nlm.nih.gov/23176543