Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Autor: María Paz Hernández-Cáceres, Karina Cereceda, Sergio Hernández, Ying Li, Carla Narro, Patricia Rivera, Patricio Silva, Yenniffer Ávalos, Claudia Jara, Paulina Burgos, Lilian Toledo-Valenzuela, Pablo Lagos, Flavia Cifuentes Araneda, Claudio Perez-Leighton, Cristina Bertocchi, Deborah J. Clegg, Alfredo Criollo, Cheril Tapia-Rojas, Patricia V. Burgos, Eugenia Morselli

Publikováno v: Molecular & Cellular Oncology, Vol 7, Iss 5 (2020)

High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuron

Externí odkaz: https://doaj.org/article/2cf149af5026454ba7c466f56d443a3e

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism

Autor: Yenniffer Ávalos, María Paz Hernández-Cáceres, Pablo Lagos, Daniela Pinto-Nuñez, Patricia Rivera, Paulina Burgos, Francisco Díaz-Castro, Michelle Joy-Immediato, Leslye Venegas-Zamora, Erik Lopez-Gallardo, Catalina Kretschmar, Ana Batista-Gonzalez, Flavia Cifuentes-Araneda, Lilian Toledo-Valenzuela, Marcelo Rodriguez-Peña, Jasson Espinoza-Caicedo, Claudio Perez-Leighton, Cristina Bertocchi, Mauricio Cerda, Rodrigo Troncoso, Valentina Parra, Mauricio Budini, Patricia V. Burgos, Alfredo Criollo, Eugenia Morselli

Publikováno v: Cell Death & Disease. 13

Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons, by a mechanism dependent on autophagy, a process of lysosomal-mediated d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d454108128cf3dad73bfea9a28b8f31e
https://doi.org/10.1038/s41419-022-05109-9

Vasopressin actions in the kidney renin angiotensin system and its role in hypertension and renal disease

Autor: Cristian Reyes-Martinez, Nicolas Salinas-Parra, Flavia Cifuentes-Araneda, Alexis A. Gonzalez

Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) is the main hormone responsible for water maintenance in the body through the antidiuretic actions in the kidney. The posterior pituitary into the blood releases vasopress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f32e82fb2de438446222a79253e3bdb
https://doi.org/10.1016/bs.vh.2019.09.003

IMPLEMENTATION OF AN ANALYTICAL METHOD FOR THE DETERMINATION OF INORGANIC ARSENIC SPECIES IN OCCUPATIONALLY EXPOSED HUMAN URINE SAMPLES AND ITS TOXIC EFFECTS ON EPITHELIAL CELLS OF RENAL COLLECTING TUBULE

Autor: Flavia Cifuentes-Araneda, Waldo Quiroz, Manuel Bravo, Helen Arias, Alexis A. Gonzalez, Nicole Roldán, Nicolas Salinas-Parra

Publikováno v: Journal of the Chilean Chemical Society v.61 n.4 2016
SciELO Chile
CONICYT Chile
instacron:CONICYT
Journal of the Chilean Chemical Society, Volume: 61, Issue: 4, Pages: 3214-3218, Published: DEC 2016

In this study a method was implemented for the determination of total As and its inorganic species in human urine by HPLC-HG-AFS. The method was applied to workers occupationally exposed to mining and thermoelectric operations. Results shows high lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e941f7cdbfdfb14f670ef2aba7fb9191
https://doi.org/10.4067/s0717-97072016000400013

Myeloid CD11c

Autor: Daniel, Hevia, Patricio, Araos, Carolina, Prado, Eugenia, Fuentes Luppichini, Macarena, Rojas, Rodrigo, Alzamora, Flavia, Cifuentes-Araneda, Alexis A, Gonzalez, Cristian A, Amador, Rodrigo, Pacheco, Luis, Michea

Publikováno v: Hypertension (Dallas, Tex. : 1979). 71(4)

Increasing evidence shows that antigen-presenting cells (APCs) are involved in the development of inflammation associated to hypertension. However, the potential role of APCs in the modulation of renal sodium transport has not been addressed. We hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d383c599957d5d456c18aec7bb9eff0
https://pubmed.ncbi.nlm.nih.gov/29378856