Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Flavia Chiuppesi"'
Autor:
Marcal Yll-Pico, Yoonsuh Park, Joy Martinez, Angelina Iniguez, Mindy Kha, Taehyun Kim, Leonard Medrano, Vu H. Nguyen, Teodora Kaltcheva, Shannon Dempsey, Flavia Chiuppesi, Felix Wussow, Don J. Diamond
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Human cytomegalovirus (CMV) is the most common infectious cause of complications post-transplantation, while a CMV vaccine for transplant recipients has yet to be licensed. Triplex, a multiantigen Modified Vaccinia Ankara (MVA)-vectored CMV
Externí odkaz:
https://doaj.org/article/7de9db78369f482a9f2be1a9c25e1148
Autor:
Flavia Chiuppesi, John A. Zaia, Miguel-Angel Gutierrez-Franco, Sandra Ortega-Francisco, Minh Ly, Mindy Kha, Taehyun Kim, Shannon Dempsey, Swagata Kar, Alba Grifoni, Alessandro Sette, Felix Wussow, Don J. Diamond
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Although the mpox global health emergency caused by mpox virus (MPXV) clade IIb.1 has ended, mpox cases are still reported due to low vaccination coverage and waning immunity. COH04S1 is a clinically evaluated, multiantigen COVID-
Externí odkaz:
https://doaj.org/article/37f7a2f654e24b8aa72abf40f899069f
Autor:
Felix Wussow, Mindy Kha, Taehyun Kim, Minh Ly, Marcal Yll-Pico, Swagata Kar, Mark G. Lewis, Flavia Chiuppesi, Don J. Diamond
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Emerging SARS-CoV-2 Omicron subvariants continue to disrupt COVID-19 vaccine efficacy through multiple immune mechanisms including neutralizing antibody evasion. We developed COH04S1, a synthetic modified vaccinia Ankara vector that co-expre
Externí odkaz:
https://doaj.org/article/35041c384f06436e9a5694235594dce6
Autor:
Corinna La Rosa, Flavia Chiuppesi, Yoonsuh Park, Qiao Zhou, Dongyun Yang, Ketevan Gendzekhadze, Minh Ly, Jing Li, Teodora Kaltcheva, Sandra Ortega Francisco, Miguel-Angel Gutierrez, Haris Ali, Salman Otoukesh, Idoroenyi Amanam, Amandeep Salhotra, Vinod A. Pullarkat, Ibrahim Aldoss, Michael Rosenzweig, Ahmed M. Aribi, Anthony S. Stein, Guido Marcucci, Sanjeet Singh Dadwal, Ryotaro Nakamura, Stephen J. Forman, Monzr M. Al Malki, Don J. Diamond
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the current post-pandemic era, recipients of an allogeneic hematopoietic stem cell transplant (HCT) deserve special attention. In these vulnerable patients, vaccine effectiveness is reduced by post-transplant immune-suppressive therapy; consequent
Externí odkaz:
https://doaj.org/article/f9e29286714a431b829fd3e49d2e0728
Autor:
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, Jennifer Drake, Cynthia Slape, Paolo Fernando, Wasima Rida, Teodora Kaltcheva, Alba Grifoni, Alessandro Sette, Angela Patterson, Shannon Dempsey, Brian Ball, Haris Ali, Amandeep Salhotra, Anthony Stein, Nitya Nathwani, Michael Rosenzweig, Liana Nikolaenko, Monzr M. Al Malki, Jana Dickter, Deepa D. Nanayakkara, Alfredo Puing, Stephen J. Forman, Randy A. Taplitz, John A. Zaia, Ryotaro Nakamura, Felix Wussow, Don J. Diamond, Sanjeet S. Dadwal
Publikováno v:
Vaccines, Vol 11, Iss 9, p 1492 (2023)
Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and are less likely than immunocompetent individuals to respond to vaccination. As
Externí odkaz:
https://doaj.org/article/0f069907108b4e64a02598493f2e56e5
Autor:
Flavia Chiuppesi, Vu H. Nguyen, Yoonsuh Park, Heidi Contreras, Veronica Karpinski, Katelyn Faircloth, Jenny Nguyen, Mindy Kha, Daisy Johnson, Joy Martinez, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Paul Frankel, Swagata Kar, Ankur Sharma, Hanne Andersen, Mark G. Lewis, Yuriy Shostak, Felix Wussow, Don J. Diamond
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Second-generation COVID-19 vaccines could contribute to establish protective immunity against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara-based SARS-CoV-2 vaccine that co-expr
Externí odkaz:
https://doaj.org/article/759512ebd0914a7ebf39111c72a326f2
Autor:
Flavia Chiuppesi, John A. Zaia, Katelyn Faircloth, Daisy Johnson, Minh Ly, Veronica Karpinski, Corinna La Rosa, Jennifer Drake, Joan Marcia, Ann Marie Acosta, Shannon Dempsey, Randy A. Taplitz, Qiao Zhou, Yoonsuh Park, Sandra Ortega Francisco, Teodora Kaltcheva, Paul H. Frankel, Steven Rosen, Felix Wussow, Sanjeet Dadwal, Don J. Diamond
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104745- (2022)
Summary: Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent s
Externí odkaz:
https://doaj.org/article/7ee89bd0a1624ab7a1390db06348e249
Autor:
Felix Wussow, Mindy Kha, Katelyn Faircloth, Vu H. Nguyen, Angelina Iniguez, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Swagata Kar, Hanne Andersen, Mark G. Lewis, Flavia Chiuppesi, Don J. Diamond
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104457- (2022)
Summary: COVID-19 vaccine efficacy is threatened by emerging SARS-CoV-2 variants of concern (VOC) with the capacity to evade protective neutralizing antibody responses. We recently developed clinical vaccine candidate COH04S1, a synthetic modified va
Externí odkaz:
https://doaj.org/article/a76f6bba437449628feb349c980b165d
Autor:
Flavia Chiuppesi, PhD, John A Zaia, ProfMD, Paul H Frankel, ProfPhD, Rodica Stan, PhD, Jennifer Drake, RN, Brenda Williams, RN, Anne Marie Acosta, LVN, Karyn Francis, RN, Randy A Taplitz, ProfMD, Janet K Dickter, MD, Sanjeet Dadwal, MD, Alfredo G Puing, MD, Deepa D Nanayakkara, MD, Patricia Ash, RN, Yujie Cui, MS, Heidi Contreras, PhD, Corinna La Rosa, PhD, Katrin Tiemann, PhD, Yoonsuh Park, PhD, Joybelle Medina, MS, Angelina Iniguez, MS, Qiao Zhou, MS, Veronica Karpinski, MS, Daisy Johnson, MS, Katelyn Faircloth, MS, Teadora Kaltcheva, PhD, Jenny Nguyen, MS, Mindy Kha, MS, Vu H Nguyen, PhD, Sandra Ortega Francisco, PhD, Alba Grifoni, PhD, Angela Wong, MS, Alessandro Sette, PhD, Felix Wussow, PhD, Don J Diamond, ProfPhD
Publikováno v:
The Lancet Microbe, Vol 3, Iss 4, Pp e252-e264 (2022)
Summary: Background: COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and immunogenicity in healthy adults. Methods: This combined open-label and ran
Externí odkaz:
https://doaj.org/article/19a51d8eae2e44b187fd29cbd3dee5ce
Autor:
Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humor
Externí odkaz:
https://doaj.org/article/df0cbf9ed7ce4cb899492b5771e12516