Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Flavia Castellano"'
Autor:
Jérôme Gatineau, Charlotte Nidercorne, Aurélie Dupont, Marie-Line Puiffe, José L. Cohen, Valérie Molinier-Frenkel, Florence Niedergang, Flavia Castellano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The secreted enzyme interleukin four-induced gene 1 (IL4I1) is involved in the negative control of the adaptive immune response. IL4I1 expression in human cancer is frequent and correlates with poor survival and resistance to immunotherapy. Neverthel
Externí odkaz:
https://doaj.org/article/afe2a638bb7a4285a292254ff95b277a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/8d46511ce2114353af3c0df8da488cbc
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The amino-acid catabolizing enzyme Interleukin-4 induced gene 1 (IL4I1) remains poorly characterized despite it is emerging as a pertinent therapeutic target for cancer. IL4I1 is secreted in the synaptic cleft by antigen-presenting cells. It inhibits
Externí odkaz:
https://doaj.org/article/863d8fa63ba44bd6b20c683de7c0c1d4
Autor:
Marie-Line Puiffe, Aurélie Dupont, Nouhoum Sako, Jérôme Gatineau, José L. Cohen, Denis Mestivier, Agnès Lebon, Armelle Prévost-Blondel, Flavia Castellano, Valérie Molinier-Frenkel
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
IL4I1 is an immunoregulatory enzyme that inhibits CD8 T-cell proliferation in vitro and in the tumoral context. Here, we dissected the effect of IL4I1 on CD8 T-cell priming by studying the differentiation of a transgenic CD8 T-cell clone and the endo
Externí odkaz:
https://doaj.org/article/fba47e775bfd4cb5a9161fcdddb9307f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Amino acids are essential for protein synthesis, epigenetic modification through the methylation of histones, and the maintenance of a controlled balance of oxidoreduction via the production of glutathione and are precursors of certain neurotransmitt
Externí odkaz:
https://doaj.org/article/189f08fc489e432a9af9097902105149
Autor:
Lloyd Bod, Renée Lengagne, Ludovic Wrobel, Jan Philipp Ramspott, Masashi Kato, Marie-Françoise Avril, Flavia Castellano, Valérie Molinier-Frenkel, Armelle Prévost-Blondel
Publikováno v:
OncoImmunology, Vol 6, Iss 3 (2017)
Amino acid catabolizing enzymes emerged as a crucial mechanism used by tumors to dampen immune responses. The L-phenylalanine oxidase IL-4 induced gene 1 (IL4I1) is expressed by tumor-associated myeloid cells of most solid tumors, including melanoma.
Externí odkaz:
https://doaj.org/article/182f3bb7dc35400f9e11f88f85e31dd6
Publikováno v:
Cells, Vol 8, Iss 7, p 757 (2019)
The high metabolic needs of T lymphocytes in response to activation make them particularly vulnerable to modifications of their biochemical milieu. Immunosuppressive enzymes produced in the tumor microenvironment modify nutrient availability by catab
Externí odkaz:
https://doaj.org/article/e673d07be5a14ff68ff1498d22e38168
Publikováno v:
Molecules, Vol 22, Iss 12, p 2151 (2017)
l-amino acid oxidases are flavin adenine dinucleotide-dependent enzymes present in all major kingdom of life, from bacteria to mammals. They participate in defense mechanisms by limiting the growth of most bacteria and parasites. A few mammalian LAAO
Externí odkaz:
https://doaj.org/article/64e288d80a5c46478e01838b819135c7
Autor:
Stéphane Kerbrat, Benoit Vingert, Marie-Pierre Junier, Flavia Castellano, François Renault-Mihara, Silvina Dos Reis Tavares, Mathieu Surenaud, France Noizat-Pirenne, Jorge Boczkowski, Georges Guellaën, Hervé Chneiweiss, Sabine Le Gouvello
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136885 (2015)
TCR-dependent and costimulation signaling, cell division, and cytokine environment are major factors driving cytokines expression induced by CD4(+) T cell activation. PEA-15 15 (Protein Enriched in Astrocyte / 15 kDa) is an adaptor protein that regul
Externí odkaz:
https://doaj.org/article/765c2b2f62114a95899bf2964aa05654
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54589 (2013)
L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H₂O₂ and ammonia. Interleukin 4 induced gene 1 (IL4I1) is a secreted LAAO expressed by macrophages
Externí odkaz:
https://doaj.org/article/24364c356e7b4bfa86785f50200ff561