Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Flavia C. Zacconi"'
Autor:
Rocío Durán, César Barrales-Martínez, Fabián Santana-Romo, Diego F. Rodríguez, Flavia C. Zacconi, Barbara Herrera
Publikováno v:
Molecules, Vol 29, Iss 8, p 1770 (2024)
In this article, we present a comprehensive computational investigation into the reaction mechanism of N-arylation of substituted aryl halides through Ullmann-type coupling reactions. Our computational findings, obtained through DFT ωB97X-D/6-311G(d
Externí odkaz:
https://doaj.org/article/3774c3d0eb284323891d9f1197a4f238
Autor:
Nitin Bharat Charbe, Flavia C. Zacconi, Venkata Krishna Kowthavarapu, Churni Gupta, Sushesh Srivatsa Palakurthi, Rajendran Satheeshkumar, Deepak K. Lokwani, Murtaza M. Tambuwala, Srinath Palakurthi
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 286 (2024)
The primary cause of atherosclerotic cardiovascular disease (ASCVD) is elevated levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in this process by binding to the LDL re
Externí odkaz:
https://doaj.org/article/2a7ee433c8e34273ba403010cb915bcc
Autor:
José Manuel Borrero‐de Acuña, Izabook Gutierrez‐Urrutia, Cristian Hidalgo‐Dumont, Carla Aravena‐Carrasco, Matias Orellana‐Saez, Nestor Palominos‐Gonzalez, Jozef B. J. H. vanDuuren, Viktoria Wagner, Lars Gläser, Judith Becker, Michael Kohlstedt, Flavia C. Zacconi, Christoph Wittmann, Ignacio Poblete‐Castro
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 6, Pp 2385-2402 (2021)
Summary Lignin‐based aromatics are attractive raw materials to derive medium‐chain length poly(3‐hydroxyalkanoates) (mcl‐PHAs), biodegradable polymers of commercial value. So far, this conversion has exclusively used the ortho‐cleavage rout
Externí odkaz:
https://doaj.org/article/4632f151d32540c9b6cdeb482b64059c
Autor:
Nitin Bharat Charbe, Carlos F. Lagos, Cristian Andrés Vilos Ortiz, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Flavia C. Zacconi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113428- (2022)
Ligand-based targeting of the receptors that are overexpressed explicitly on cancer cells represents an effective drug delivery approach to enhance the chemotherapeutic efficacy. Proprotein convertase subtilisin/kexin type 9 (PCSK9) which is a serine
Externí odkaz:
https://doaj.org/article/0ae72f54e64e447f8145db44c7ce1d5e
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1333 (2023)
Many pharmaceutically active molecules are highly lipophilic, which renders their administration and adsorption in patients extremely challenging. Among the countless strategies to overcome this problem, synthetic nanocarriers have demonstrated super
Externí odkaz:
https://doaj.org/article/b8eafd17720b4e098a2bc17273509eae
Autor:
Nory Mariño-Ocampo, Diego F. Rodríguez, Daniel Guerra Díaz, Daniel Zúñiga-Núñez, Yorley Duarte, Denis Fuentealba, Flavia C. Zacconi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4900 (2023)
Direct FXa inhibitors are an important class of bioactive molecules (rivaroxaban, apixaban, edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular pathologies. The interaction of active compounds with human serum albumin (
Externí odkaz:
https://doaj.org/article/9b431240286c4ca2a576ef7fa7b0361d
Autor:
Javier Salazar, Thais Carmona, Flavia C. Zacconi, Diego Venegas-Yazigi, Claudio Cabello-Verrugio, Won Il Choi, Cristian Vilos
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 10 (2022)
Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its co
Externí odkaz:
https://doaj.org/article/2cc67d2b7eaf49ce8c990507e2c2c862
Autor:
Nicolás Núñez-Navarro, Javier Salazar Muñoz, Francisco Castillo, César A. Ramírez-Sarmiento, Ignacio Poblete-Castro, Flavia C. Zacconi, Loreto P. Parra
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12544 (2022)
Indigoids are natural pigments obtained from plants by ancient cultures. Romans used them mainly as dyes, whereas Asian cultures applied these compounds as treatment agents for several diseases. In the modern era, the chemical industry has made it po
Externí odkaz:
https://doaj.org/article/5ea9871f250a4f2eb08b17410c462893
Autor:
Diego F. Rodríguez, Francisca Durán-Osorio, Yorley Duarte, Pedro Olivares, Yanina Moglie, Kamal Dua, Flavia C. Zacconi
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 33 (2021)
Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, w
Externí odkaz:
https://doaj.org/article/903e7af44c5941b29b28f69e542373dc
Autor:
Fabián Santana-Romo, Carlos F. Lagos, Yorley Duarte, Francisco Castillo, Yanina Moglie, Miguel A. Maestro, Nitin Charbe, Flavia C. Zacconi
Publikováno v:
Molecules, Vol 25, Iss 3, p 491 (2020)
The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation cascade. Moreover, FXa plays a vital ro
Externí odkaz:
https://doaj.org/article/c44b7840d55a4af6b00e7dbf344236fa