Výsledky vyhledávání - "Flavia C G Reis"

Akademický článek

Chagas Disease Diagnosis with Trypanosoma cruzi-Exclusive Epitopes in GFP

Autor: Andressa da M. Durans, Paloma Napoleão-Pêgo, Flavia C. G. Reis, Evandro R. Dias, Luciana E. S. F. Machado, Guilherme C. Lechuga, Angela C. V. Junqueira, Salvatore G. De-Simone, David W. Provance

Publikováno v: Vaccines, Vol 12, Iss 9, p 1029 (2024)

Serological tests are critical tools in the fight against infectious disease. They detect antibodies produced during an adaptive immune response against a pathogen with an immunological reagent, whose antibody binding characteristics define the speci

Externí odkaz: https://doaj.org/article/57aa5caa65df42e6ab2733246225fea1

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Akademický článek

Screening of the Pandemic Response Box Reveals an Association between Antifungal Effects of MMV1593537 and the Cell Wall of Cryptococcus neoformans, Cryptococcus deuterogattii, and Candida auris

Autor: Haroldo C. de Oliveira, Rafael F. Castelli, Flavia C. G. Reis, Kirandeep Samby, Joshua D. Nosanchuk, Lysangela R. Alves, Marcio L. Rodrigues

Publikováno v: Microbiology Spectrum, Vol 10, Iss 3 (2022)

ABSTRACT There is an urgent unmet need for novel antifungals. In this study, we searched for novel antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse compounds in various phases of drug discovery. We identifi

Externí odkaz: https://doaj.org/article/587ddf021ead413daf2ba570cf83f622

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Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors

Autor: Daniel Felipe Freitas De Jesus, Aline Luiza Duarte De Freitas, Isadora Maria De Oliveira, Larissa Costa De Almeida, Rafael Wesley Bastos, Cristina de Castro Spadari, Analy Sales de Azevedo Melo, Daniel de Assis Santos, Letícia Veras Costa-Lotufo, Flavia C. G. Reis, Marcio L. Rodrigues, Hélio Alexandre Stefani, Kelly Ishida

Publikováno v: Antimicrobial Agents and Chemotherapy.

Cryptococcosis therapy is often limited by toxicity problems, antifungal tolerance, and high costs. Studies approaching chalcogen compounds, especially those containing selenium, have shown promising antifungal activity against pathogenic species.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a93b733ff484bc8df91a646ce2e894c
https://doi.org/10.1128/aac.00759-22

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Akademický článek

Pathogenic Delivery: The Biological Roles of Cryptococcal Extracellular Vesicles

Autor: Haroldo C. de Oliveira, Rafael F. Castelli, Flavia C. G. Reis, Juliana Rizzo, Marcio L. Rodrigues

Publikováno v: Pathogens, Vol 9, Iss 9, p 754 (2020)

Extracellular vesicles (EVs) are produced by all domains of life. In fungi, these structures were first described in Cryptococcus neoformans and, since then, they were characterized in several pathogenic and non-pathogenic fungal species. Cryptococca

Externí odkaz: https://doaj.org/article/926b367c703c4d04aff1415a4deb5db8

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Extracellular vesicle formation in Cryptococcus deuterogattii impacts fungal virulence and requires the NOP16 gene

Autor: Rafael F. Castelli, Alana Pereira, Leandro Honorato, Alessandro Valdez, Haroldo C. de Oliveira, Jaqueline M. Bazioli, Ane W. A. Garcia, Tabata D’Maiella Freitas Klimeck, Flavia C. G. Reis, Charley C. Staats, Leonardo Nimrichter, Taícia P. Fill, Marcio L. Rodrigues

Publikováno v: Infect Immun

Small molecules are components of fungal extracellular vesicles (EVs), but their biological roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity of benzimidazoles against Cryptococcus deuterogattii. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b58c6b196ca34a5827618b5ac28e7d
https://doi.org/10.1101/2022.06.06.494995

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Biogenesis of Fungal Extracellular Vesicles: What Do We Know?

Autor: Haroldo C, de Oliveira, Amanda F, Kato, Bianca A G, Sena, Iraine, Duarte, Luísa J, Jozefowicz, Rafael F, Castelli, Diogo, Kuczera, Flavia C G, Reis, Lysangela Ronalte, Alves, Marcio L, Rodrigues

Publikováno v: Current topics in microbiology and immunology. 432

So far, extracellular vesicles (EVs) have been described in 15 genera of fungi. They carry molecules that contribute to the interaction of fungal cells with the host. Although the number of studies on fungal EVs has increased, the mechanisms involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::824b902eeeaaff3b956a5e1999327e14
https://pubmed.ncbi.nlm.nih.gov/34972873

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Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal–macrophage interaction

Autor: Eric H Jung, Yoon-Dong Park, Quigly Dragotakes, Lia S Ramirez, Daniel Q Smith, Flavia C G Reis, Amanda Dziedzic, Marcio L Rodrigues, Rosanna P Baker, Peter R Williamson, Anne Jedlicka, Arturo Casadevall, Carolina Coelho

Publikováno v: microLife. 3

Cryptococcus neoformans is a facultative intracellular pathogen that can replicate and disseminate in mammalian macrophages. In this study, we analyzed fungal proteins identified in murine macrophage-like cells after infection with C. neoformans. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7ab85d10d5e900bb4cd6222a91abed5
https://doi.org/10.1093/femsml/uqac015

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Analysis of Cryptococcal Extracellular Vesicles: Experimental Approaches for Studying Their Diversity Among Multiple Isolates, Kinetics of Production, Methods of Separation, and Detection in Cultures of Titan Cells

Autor: Rafael F Castelli, Lysangela R. Alves, Flavia C. G. Reis, Sharon T. Martins, Marcio L. Rodrigues, Haroldo Cesar de Oliveira, Luísa J. Jozefowicz, Bianca Gimenez

Publikováno v: Microbiology Spectrum, Vol 9, Iss 1 (2021)
Microbiology Spectrum

Extracellular vesicles (EVs) produced by members of the Cryptococcus genus are associated with fundamental processes of fungal physiology and virulence. However, several questions about the properties of cryptococcal EVs remain unanswered, mostly bec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcbd85d23d3f3b8b9a042c48d72ce9e
https://journals.asm.org/doi/10.1128/Spectrum.00125-21

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Cryptococcus extracellular vesicles properties and their use as vaccine platforms

Autor: Juliana Rizzo, Sarah Sze Wah Wong, Anastasia D. Gazi, Frédérique Moyrand, Thibault Chaze, Pierre‐Henri Commere, Sophie Novault, Mariette Matondo, Gérard Péhau‐Arnaudet, Flavia C. G. Reis, Matthijn Vos, Lysangela R. Alves, Robin C. May, Leonardo Nimrichter, Marcio L. Rodrigues, Vishukumar Aimanianda, Guilhem Janbon

Publikováno v: Journal of extracellular vesicles
Journal of extracellular vesicles, 2021, 10 (10), pp.e12129. ⟨10.1002/jev2.12129⟩
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)

International audience; Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology. Here we provide a robust set of data regarding the structural and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f51066f032cccd04b0623d1d78363934
https://hal-pasteur.archives-ouvertes.fr/pasteur-03247018

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