Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Flavia Autore"'
Autor:
Lisa A. Stott, Cheryl A. Brighton, Jason Brown, Richard Mould, Kirstie A. Bennett, Robert Newman, Heather Currinn, Flavia Autore, Alicia P. Higueruelo, Benjamin G. Tehan, Cliona MacSweeney, Michael A. O'Brien, Steve P. Watson
Publikováno v:
Heliyon, Vol 7, Iss 6, Pp e07201- (2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Externí odkaz:
https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1
Autor:
Jeroen Claus, Gargi Patel, Flavia Autore, Audrey Colomba, Gregory Weitsman, Tanya N Soliman, Selene Roberts, Laura C Zanetti-Domingues, Michael Hirsch, Francesca Collu, Roger George, Elena Ortiz-Zapater, Paul R Barber, Boris Vojnovic, Yosef Yarden, Marisa L Martin-Fernandez, Angus Cameron, Franca Fraternali, Tony Ng, Peter J Parker
Publikováno v:
eLife, Vol 7 (2018)
While targeted therapy against HER2 is an effective first-line treatment in HER2+ breast cancer, acquired resistance remains a clinical challenge. The pseudokinase HER3, heterodimerisation partner of HER2, is widely implicated in the resistance to HE
Externí odkaz:
https://doaj.org/article/05bdc0b657ae488494f7ad21996d47c6
Autor:
Flavia Autore, Mark Pfuhl, Xueping Quan, Aisling Williams, Roland G Roberts, Catherine M Shanahan, Franca Fraternali
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63633 (2013)
Nesprin-1 and nesprin-2 are nuclear envelope (NE) proteins characterized by a common structure of an SR (spectrin repeat) rod domain and a C-terminal transmembrane KASH [Klarsicht-ANC-Syne-homology] domain and display N-terminal actin-binding CH (cal
Externí odkaz:
https://doaj.org/article/c4d82715b36b4818a5bfc3da7917e11c
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40098 (2012)
BACKGROUND:Nesprins (Nuclear envelope spectrin-repeat proteins) are a novel family of giant spectrin-repeat containing proteins. The nesprin-1 and nesprin-2 genes consist of 146 and 116 exons which encode proteins of ∼1mDa and ∼800 kDa is size re
Externí odkaz:
https://doaj.org/article/7423d3bf674949a185c06fd91470e38a
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11515 (2010)
The human APOBEC3G (A3G) protein is a cellular polynucleotide cytidine deaminase that acts as a host restriction factor of retroviruses, including HIV-1 and various transposable elements. Recently, three NMR and two crystal structures of the catalyti
Externí odkaz:
https://doaj.org/article/aa4a48d320af45168192b7a3ab01e5f5
Publikováno v:
PLoS Pathogens, Vol 5, Iss 3, p e1000330 (2009)
The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates. A3G contains two canonical cytidine deaminase
Externí odkaz:
https://doaj.org/article/2e8cc2ed05354ef5a01c755cd8568ceb
Autor:
Robert Newman, Benjamin G. Tehan, J.D. Brown, Richard Mould, Alicia P. Higueruelo, K.A. Bennett, O'brien Michael Alistair, Flavia Autore, Cliona MacSweeney, Heather Currinn, Cheryl A. Brighton, Lisa A. Stott, Steve P. Watson
Publikováno v:
Heliyon
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Autor:
Paul R. Barber, Yosef Yarden, Roger George, Gargi Patel, Flavia Autore, Boris Vojnovic, Gregory Weitsman, Audrey Colomba, Marisa L. Martin-Fernandez, Selene K. Roberts, Peter J. Parker, Laura C. Zanetti-Domingues, Tony Ng, Michael Hirsch, Francesca Collu, Angus J.M. Cameron, Franca Fraternali, Tanya N. Soliman, Elena Ortiz-Zapater, Jeroen Claus
Publikováno v:
Claus, J, Patel, G, Autore, F, Colomba, A, Weitsman, G, Soliman, T N, Roberts, S, Zanetti Domingues, L C, Hirsch, M, Collu, F, George, R, Ortiz-Zapater, E, Barber, P R, Vojnovic, B, Yarden, Y, Martin-Fernandez, M L, Cameron, A, Fraternali, F, Ng, T & Parker, P J 2018, ' Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface ', eLife, vol. 7, e32271 . https://doi.org/10.7554/eLife.32271
eLife
eLife, Vol 7 (2018)
eLife
eLife, Vol 7 (2018)
While targeted therapy against HER2 is an effective first-line treatment in HER2+ breast cancer, acquired resistance remains a clinical challenge. The pseudokinase HER3, heterodimerisation partner of HER2, is widely implicated in the resistance to HE
Autor:
Francesca Collu, Tony Ng, Paul R. Barber, Jeroen Claus, Gargi Patel, Franca Fraternali, Gregory Weitsman, Angus J.M. Cameron, Michael Hirsch, Peter J. Parker, Roger George, Flavia Autore, Marisa L. Martin-Fernandez, Laura C. Zanetti-Domingues, Boris Vojnovic, Yosef Yarden, Tanya N. Soliman, Elena Ortiz-Zapater, Selene K. Roberts, Audrey Colomba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec3894b79dd4cc103426160cb78a6061
https://doi.org/10.7554/elife.32271.037
https://doi.org/10.7554/elife.32271.037
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1411
Nesprins are a family of multi-isomeric scaffolding proteins that were originally identified at the nuclear envelope (NE), where they bind to lamin A/C, emerin, and SUN-domain containing proteins, to form the LInker of Nucleoskeleton-and-Cytoskeleton