Development of a prediction model of conversion to Alzheimer’s disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project

Autor: Flavia L. Lombardo, Patrizia Lorenzini, Flavia Mayer, Marco Massari, Paola Piscopo, Ilaria Bacigalupo, Antonio Ancidoni, Francesco Sciancalepore, Nicoletta Locuratolo, Giulia Remoli, Simone Salemme, Stefano Cappa, Daniela Perani, Patrizia Spadin, Fabrizio Tagliavini, Alberto Redolfi, Maria Cotelli, Camillo Marra, Naike Caraglia, Fabrizio Vecchio, Francesca Miraglia, Paolo Maria Rossini, Nicola Vanacore, the INTERCEPTOR Network

Publikováno v: Diagnostic and Prognostic Research, Vol 8, Iss 1, Pp 1-11 (2024)

Abstract Background In recent years, significant efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (mild cognitive impairment, MCI) and/or early stages of Alzhe

Externí odkaz: https://doaj.org/article/179f70c48a084692b2d8c1eb22dc4865

A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial

Autor: Flavia L. Lombardo, Stefania Spila Alegiani, Flavia Mayer, Marta Cipriani, Maria Lo Giudice, Albert Christian Ludolph, Christopher J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gabriele Nicolini, Nicola Vanacore, Brian Dickie, Alberto Albanese, Maria Puopolo, TUDCA-ALS Study Group

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-11 (2023)

Abstract Background Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements in therape

Externí odkaz: https://doaj.org/article/e605a690f8ca4aaeb2de409c0f411d52

Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol

Autor: Alberto Albanese, Albert Christian Ludolph, Christopher J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, TUDCA-ALS Study Group, Paolo Tornese, Antoniangela Cocco, Maria Lo Giudice, Michela Matteoli, Eliana Lauranzano, Maria Luisa Malosio, Chiara Adriana Elia, Flavia Lombardo, Flavia Mayer, Maria Puopolo, Stefania Spila Alegiani, Adriano Chiò, Umberto Manera, Cristina Moglia, Andrea Calvo, Paolina Salamone, Giuseppe Fuda, Carlo Colosimo, Cristina Spera, Prabha Cristina Ranchicchio, Giuseppe Stipa, Domenico Frondizi, Christian Lunetta, Valeria Sansone, Claudia Tarlarini, Francesca Gerardi, Vincenzo Silani, Alberto Doretti, Eleonora Colombo, Gianluca Demirtzidis, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Stefania Ballestrero, Johannes Dorst, Ulrike Weiland, Andrea Fromm, Maximilian Wiesenfarth, Katharina Kandler, Simon Witzel, Markus Otto, Joachim Schuster, Thomas Meyer, André Maier, Dagmar Kettemann, Susanne Petri, Lars Müschen, Camilla Wohnrade, Anastasia Sarikidi, Alma Osmanovic, Julian Grosskreutz, Annekathrin Rödiger, Robert Steinbach, Benjamin Ilse, Uta Smesny, Robert Untucht, René Günther, Maximilian Vidovic, Pamela Shaw, Alexis Collins, Helen Wollff, Theresa Walsh, Lee Tuddenham, Mbombe Kazoka, David White, Stacy Young, Benjamin Thompson, Daniel Madarshahian, Suresh K. Chhetri, Amina Chaouch, Carolyn A. Young, Heike Arndt, Oliver C Hanemann, Thomas Lambert, Stephane Beltran, Philippe Couratier, Florence Esselin, William Camu, Elisa De, La Cruz, Gwendal Lemasson, Pegah Masrori, Sinead Maguire, Liz Fogarty, Toyosi Atoyebi, Niamh Ní Obáin

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundAmyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that affects motor neurons in the brain, brainstem, and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. Although much

Externí odkaz: https://doaj.org/article/499f4c22c4474ff6bbb12e36ba086577

Adverse Events in Italian Nursing Homes During the COVID-19 Epidemic: A National Survey

Autor: Flavia L. Lombardo, Emanuela Salvi, Eleonora Lacorte, Paola Piscopo, Flavia Mayer, Antonio Ancidoni, Giulia Remoli, Guido Bellomo, Gilda Losito, Fortunato D’Ancona, Marco Canevelli, Graziano Onder, Nicola Vanacore, The Italian National Institute of Health Nursing Home Study Group, Ilaria Bacigalupo, Luigi Bertinato, Patrizia Carbonari, Maria Grazia Carella, Annamaria Confaloni, Alessio Crestini, Carla Faralli, Simone Fiaccavento, Silvia Francisci, Cinzia Lo Noce, Paola Luzi, Tania Lopez, Maria Masocco, Monica Mazzola, Ilaria Palazzesi, Luana Penna, Daniela Pierannunzio, Maria Cristina Porrello, Giulia Scaravelli, Andrea Siddu, Sabrina Sipone, Lucia Speziale, Andrea Tavilla, Mauro Palma, Gianluca Pucciarelli, Daniela Accorgi, Catia Bedosti, Gabriella Carraro, Maria Mongardi, Gianluca Ferrari

Publikováno v: Frontiers in Psychiatry, Vol 11 (2020)

Older people living in nursing homes (NHs) are particularly vulnerable in the ongoing COVID-19 pandemic, due to the high prevalence of chronic diseases and disabilities (e.g., dementia). The phenomenon of adverse events (AEs), intended as any harm or

Externí odkaz: https://doaj.org/article/0f618f36cec144a5b5d619f89cb3e7d0

Dementia among migrants and ethnic minorities in Italy: rationale and study protocol of the ImmiDem project

Autor: Nicola Vanacore, Flavia Mayer, Marco Canevelli, Eleonora Lacorte, Ilaria Cova, Silvia Cascini, Anna Maria Bargagli, Laura Angelici, Angela Giusti, Simone Pomati, Leonardo Pantoni, Ilaria Bacigalupo, Guido Bellomo, Giuseppe Gervasi, Francesca Marchetti, Monica Mazzola, Ilaria Palazzesi, Paola Piscopo, Mariacristina Porrello, Emanuela Salvi, Valerio Zaccaria, Francesca Zambri, Giuseppe Bruno, Martina Valletta

Publikováno v: BMJ Open, Vol 10, Iss 1 (2020)

Introduction Due to the ongoing demographic and epidemiological transitions, estimating the phenomenon of dementia in migrants and minority groups, exploring its characteristics and challenges and implementing dedicated healthcare policies, constitut

Externí odkaz: https://doaj.org/article/80d3b53076ea4f27a7dd80847c2e89a8