Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Flauaus, C."'
Autor:
Hiesinger, K., Kramer, J.S., Beyer, S., Eckes, T., Brunst, S., Flauaus, C., Wittmann, S.K., Weizel, L., Kaiser, A., Kretschmer, S.B.M., George, S., Angioni, C., Heering, J., Geisslinger, G., Schubert-Zsilavecz, M., Schmidtko, A., Pogoryelov, D., Pfeilschifter, J., Hofmann, B., Steinhilber, D., Schwalm, S., Proschak, E.
Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. Merging of 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH) pharmacophores led to the discovery of a dual 5-LOX/sEH inhibitor, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::c07111b1bc9589c2536a41f7ea81da3d
https://publica.fraunhofer.de/handle/publica/265846
https://publica.fraunhofer.de/handle/publica/265846
Autor:
Kallenborn-Gerhardt, W., Lu, R., Petersen, J.J., Metzner, K., Kuth, M.S., Heine, S., Drees, O., Paul, M., Becirovic, E., Kennel, L., Flauaus, C., Gross, T., Wack, G., Hohmann, S.W., Turco, D. del, Biel, M., Geisslinger, G., Michalakis, S., Schmidtko, A.
Question: Several cAMP and cGMP signaling pathways contribute to the generation of chronic pain conditions. However, the downstream targets of cAMP- and cGMP-dependent signaling in this context are not completely understood. One important target of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______610::dae5b2e6cc93ef718a11e207f379f48d
https://publica.fraunhofer.de/handle/publica/258395
https://publica.fraunhofer.de/handle/publica/258395
Autor:
Balzulat A; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Zhu WF; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Flauaus C; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Hernandez-Olmos V; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Sethumadhavan S; Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Dubiel M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany., Frank A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany., Menge A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany., Hebchen M; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Metzner K; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Lu R; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Lukowski R; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Ruth P; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany., Müller S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Hänelt I; Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany., Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Schmidtko A; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Publikováno v:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Apr; Vol. 11 (15), pp. e2307237. Date of Electronic Publication: 2024 Feb 13.
Autor:
Dignass A; Department of Medicine I, Agaplesion Markus Hospital, Frankfurt/Main, Germany., Esters P; Department of Medicine I, Agaplesion Markus Hospital, Frankfurt/Main, Germany., Flauaus C; AbbVie Deutschland GmbH & Co. KG, Medical Immunology, Wiesbaden, Germany.
Publikováno v:
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2024 Mar; Vol. 25 (4), pp. 359-370. Date of Electronic Publication: 2024 Mar 29.
Autor:
Flauaus C; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany., Engel P; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany., Zhou F; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany., Petersen J; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany., Ruth P; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Tuebingen, Germany., Lukowski R; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Tuebingen, Germany., Schmidtko A; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany., Lu R; Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany.
Publikováno v:
Anesthesiology [Anesthesiology] 2022 May 01; Vol. 136 (5), pp. 802-822.
Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.
Autor:
Lu R; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Metzner K; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Zhou F; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Flauaus C; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Balzulat A; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Engel P; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Petersen J; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany., Ehinger R; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Baden-Württemberg, Germany., Bausch A; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Baden-Württemberg, Germany., Ruth P; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Baden-Württemberg, Germany., Lukowski R; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Baden-Württemberg, Germany., Schmidtko A; Institut für Pharmakologie und Klinische Pharmazie, Goethe-Universität Frankfurt am Main, 60438 Frankfurt am Main, Hessen, Germany.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 02; Vol. 22 (1). Date of Electronic Publication: 2021 Jan 02.
Autor:
Hiesinger K; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Kramer JS; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Beyer S; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Eckes T; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Brunst S; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Flauaus C; Institute of Pharmacology and Clinical Pharmacy, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany., Wittmann SK; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Weizel L; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Kaiser A; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Kretschmer SBM; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., George S; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Angioni C; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Heering J; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Geisslinger G; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Schubert-Zsilavecz M; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Schmidtko A; Institute of Pharmacology and Clinical Pharmacy, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany., Pogoryelov D; Institute of Biochemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9, D-60438 Frankfurt a.M., Germany., Pfeilschifter J; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Hofmann B; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Schwalm S; Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, ZAFES, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Max-von-Laue Str. 9 D-60438 Frankfurt a.M., Germany.; Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11498-11521. Date of Electronic Publication: 2020 Oct 12.
Autor:
Kallenborn-Gerhardt W; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596, Frankfurt am Main, Germany. Electronic address: kallenborn@med.uni-frankfurt.de., Metzner K; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Lu R; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Petersen J; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Kuth MS; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Heine S; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596, Frankfurt am Main, Germany., Drees O; Institute of Pharmacology and Toxicology, ZBAF, Witten/Herdecke University, 58453, Witten, Germany., Paul M; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, 60596, Frankfurt am Main, Germany., Becirovic E; Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, 81377, Munich, Germany., Kennel L; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Flauaus C; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Gross T; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Wack G; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Hohmann SW; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596, Frankfurt am Main, Germany., Nemirovski D; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany., Del Turco D; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, 60596, Frankfurt am Main, Germany., Biel M; Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, 81377, Munich, Germany., Geisslinger G; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, 60596, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology - Project Group Translational Medicine and Pharmacology (IME-TMP), 60596, Frankfurt am Main, Germany., Michalakis S; Center for Integrated Protein Science Munich CiPSM at the Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, 81377, Munich, Germany., Schmidtko A; Institute of Pharmacology and Clinical Pharmacy, Goethe University, 60438, Frankfurt am Main, Germany.
Publikováno v:
Neuropharmacology [Neuropharmacology] 2020 Jul; Vol. 171, pp. 108087. Date of Electronic Publication: 2020 Apr 06.
Autor:
Schierle S; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Flauaus C; Institute of Pharmacology, College of Pharmacy , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Heitel P; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Willems S; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Schmidt J; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Kaiser A; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Weizel L; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Goebel T; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Kahnt AS; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Geisslinger G; Institute of Clinical Pharmacology , Goethe University Frankfurt , Theodor-Stern-Kai 7 , D-60590 Frankfurt , Germany., Steinhilber D; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Wurglics M; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Rovati GE; Institute of Pharmacological Sciences , University of Milan , Via Balzaretti 9 , I-20133 Milan , Italy., Schmidtko A; Institute of Pharmacology, College of Pharmacy , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Proschak E; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany., Merk D; Institute of Pharmaceutical Chemistry , Goethe University Frankfurt , Max-von-Laue-Straße 9 , D-60438 Frankfurt , Germany.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2018 Jul 12; Vol. 61 (13), pp. 5758-5764. Date of Electronic Publication: 2018 Jun 22.
Autor:
Lu R; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany; Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, ZBAF, 58453 Witten, Germany. Electronic address: Lu@em.uni-frankfurt.de., Flauaus C; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany., Kennel L; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany., Petersen J; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany; Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, ZBAF, 58453 Witten, Germany., Drees O; Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, ZBAF, 58453 Witten, Germany., Kallenborn-Gerhardt W; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany., Ruth P; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Germany., Lukowski R; Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Universität Tübingen, 72076 Tübingen, Germany., Schmidtko A; Pharmakologisches Institut für Naturwissenschaftler, Goethe-Universität, Fachbereich Biochemie, Chemie und Pharmazie, 60438 Frankfurt am Main, Germany; Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, ZBAF, 58453 Witten, Germany.
Publikováno v:
Neuropharmacology [Neuropharmacology] 2017 Oct; Vol. 125, pp. 386-395. Date of Electronic Publication: 2017 Aug 18.