Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Autor: Mcconnell, Mj, Moran, Jv, Abyzov, A, Akbarian, S, Bae, T, Cortes-Ciriano, I, Erwin, Ja, Fasching, L, Flasch, Da, Freed, D, Ganz, J, Jaffe, Ae, Kwan, Ky, Kwon, M, Lodato, Ma, Mills, Re, Paquola, Acm, Rodin, Re, Rosenbluh, C, Sestan, N, Sherman, Ma, Shin, Jh, Song, S, Straub, Re, Thorpe, J, Weinberger, Dr, Urban, Ae, Zhou, B, Gage, Fh, Lehner, T, Senthil, G, Walsh, Ca, Chess, A, Courchesne, E, Gleeson, Jg, Kidd, Jm, Park, Pj, Pevsner, J, Vaccarino, Fm, Barton, Ar, Bekiranov, S, Bohrson, Cl, Burbulis, Ie, Chronister, W, Coppola, G, Daily, K, D'Gama, Am, Emery, Sb, Frisbie, Tj, Gao, T, Gulyás-Kovács, A, Haakenson, M, Keil, Jm, Kopera, Hc, Lam, Mm, Lee, Ea, Marques-Bonet, T, Mathern, Gw, Moldovan, Jb, Oetjens, Mt, Omberg, L, Peters, Ma, Pochareddy, S, Pramparo, T, Ratan, A, Sanavia, T, Shi, L, Skarica, M, Wang, J, Wang, M, Wang, Y, Wierman, M, Wolpert, M, Woodworth, M, Zhao, X, Zhou, W

BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a major scientific and medical challenge. Emerging genomic technologies now permit the analysis of somatic mosaicism in human tissues. The measured frequencies of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dde4d1a89eae6cc76040638118b15b5
http://hdl.handle.net/2318/1731623

The genomic landscape of pediatric acute lymphoblastic leukemia.

Autor: Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gu Z; Department of Computational and Quantitative Medicine & Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA., Shi L; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pei D; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Dai Y; Department of Biostatistics, University of Florida, Gainesville, FL, USA., Devidas M; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA., Qu C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hill AN; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Payne-Turner D; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Baviskar P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wei L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Arunachalam S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hagiwara K; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Flasch DA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Parker M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Elsayed AH; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pathak O; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Li Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Fan Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Michael JR; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wilkinson MR; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Foy S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hedges DJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Newman S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Reilly C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Sioson E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rice SV; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pastor Loyola V; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Rampersaud E; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Reshmi SC; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Gastier-Foster J; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Office of Data Sharing, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gesuwan P; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Smith MA; Cancer Therapeutics Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Winick N; Department of Pediatric Hematology Oncology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Heerema NA; The Ohio State University, Columbus, OH, USA., Harvey RC; Department of Pathology, University of New Mexico Cancer Center, Albuquerque, NM, USA., Willman CL; Mayo Clinical Comprehensive Cancer Center, Rochester, MN, USA., Larsen E; Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME, USA., Raetz EA; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Borowitz MJ; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA., Wood BL; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA., Carroll WL; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Zweidler-McKay PA; ImmunoGen, Inc., Waltham, MA, USA., Rabin KR; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Mattano LA; HARP Pharma Consulting, Mystic, CT, USA., Maloney KW; Department of Pediatrics and Children's Hospital Colorado, University of Colorado, Aurora, CO, USA., Winter SS; Children's Minnesota Research Institute and Cancer and Blood Disorders Program, Minneapolis, MN, USA., Burke MJ; Division of Pediatric Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Salzer W; Uniformed Services University, School of Medicine, Bethesda, MD, USA., Dunsmore KP; Department of Pediatrics, University of Virginia, Charlottesville, VA, USA., Angiolillo AL; Children's National Medical Center, Washington, DC, USA., Crews KR; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Jeha S; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Evans WE; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang JJ; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Relling MV; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Gerhard DS; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Loh ML; Department of Pediatrics, Benioff Children's Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Hungers@chop.edu., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. jinghui.zhang@stjude.org., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.

Publikováno v: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1376-1389. Date of Electronic Publication: 2022 Sep 01.

Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology.

Autor: Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA., Emery SB; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA., Flasch DA; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA., Wang Y; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA., Kwan KY; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA.; Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA., Kidd JM; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA., Moran JV; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA.; Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA., Mills RE; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Feb 20; Vol. 48 (3), pp. 1146-1163.

Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity with Replication.

Autor: Flasch DA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA. Electronic address: daflasch@umich.edu., Macia Á; Department of Genomic Medicine, GENYO: Centre for Genomics and Oncology (Pfizer-University of Granada and Andalusian Regional Government), PTS Granada, 18016, Spain., Sánchez L; Department of Genomic Medicine, GENYO: Centre for Genomics and Oncology (Pfizer-University of Granada and Andalusian Regional Government), PTS Granada, 18016, Spain., Ljungman M; Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Translational Oncology Program and Center for RNA Biomedicine, University of Michigan, Ann Arbor, Michigan, 48109, USA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, 48109, USA., Heras SR; Department of Genomic Medicine, GENYO: Centre for Genomics and Oncology (Pfizer-University of Granada and Andalusian Regional Government), PTS Granada, 18016, Spain., García-Pérez JL; Department of Genomic Medicine, GENYO: Centre for Genomics and Oncology (Pfizer-University of Granada and Andalusian Regional Government), PTS Granada, 18016, Spain; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Wilson TE; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA. Electronic address: wilsonte@umich.edu., Moran JV; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA. Electronic address: moranj@umich.edu.

Publikováno v: Cell [Cell] 2019 May 02; Vol. 177 (4), pp. 837-851.e28. Date of Electronic Publication: 2019 Apr 04.

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

Autor: McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM

Publikováno v: Science (New York, N.Y.) [Science] 2017 Apr 28; Vol. 356 (6336). Date of Electronic Publication: 2017 Apr 27.