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The Platform trial In COVID-19 vaccine priming and BOOsting (PICOBOO) booster vaccination substudy protocol

Autor: McLeod C, Dymock M, Flanagan KL, Plebanski M, Marshall H, Marsh J, Estcourt MJ, Ramsay J, Wadia U, Williams PCM, Tjiam MC, Blyth C, Subbarao K, Nicholson S, Faust S.N., Thornton RB, Mckenzie A, Snelling T, Richmond P

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-10 (2024)

Abstract Background Coronavirus-2019 (COVID-19) vaccination in Australia commenced in February 2021. The first vaccines recommended for use were AZD1222 and BNT162b2, both delivered as a two-dose primary schedule. In the absence of sustained immunity

Externí odkaz: https://doaj.org/article/bf1529a9360c49c191e21caa73f4ccfa

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Akademický článek

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Global Perspectives on Immunization Against SARS-CoV-2 During Pregnancy and Priorities for Future Research: An International Consensus Paper From the World Association of Infectious Diseases and Immunological Disorders

Autor: Abu-Raya B, Madhi SA, Omer SB, Amirthalingam G, Giles ML, Flanagan KL, Zimmermann P, O'Ryan M, Safadi MA, Papaevangelou V, Maertens K, Wanlapakorn N, Vicens Diaz de Brito Fernandez, Tommelein E, Esposito S

Publikováno v: FRONTIERS IN IMMUNOLOGY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b6b72211ef904c0aae3eeb12fdd5794e
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20550

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Viral Vector Malaria Vaccines Induce High-Level T Cell and Antibody Responses in West African Children and Infants

Publikováno v: Molecular Therapy

Heterologous prime-boosting with viral vectors encoding the pre-erythrocytic antigen thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) induces CD8+ T cell-mediated immunity to malaria sporozoite challenge in Europea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::71a1ea9acc0321e0c0b0f33915d31e0e

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New therapeutic targets for the prevention of infectious acute exacerbations of COPD: Role of epithelial adhesion molecules and inflammatory pathways

Autor: Atto, B, Eapen, MS, Sharma, P, Frey, U, Ammit, AJ, Markos, J, Chia, C, Larby, J, Haug, G, Weber, HC, Mabeza, G, Tristram, S, Myers, S, Geraghty, DP, Flanagan, KL, Hansbro, PM, Sohal, SS

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society Chronic respiratory diseases are among the leading causes of mortality worldwide, with the major contributor, chronic obstructive pulmonary disease (COPD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::9f141f685a462f88d92323ccc4f3a6ad
https://hdl.handle.net/10453/134927

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Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines

Autor: Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, Tan T, Knuf M, Rodrigo C, Weil Olivier C, Flanagan KL, Hung I, Lutsar I, Edwards K, O'Ryan M, Principi N

Publikováno v: Frontiers in Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e6a3beb758eb09ace5a1ff3057ca9088
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5267

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Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

Autor: Nyamweya, S, Hegedus, A, Jaye, A, Rowland-Jones, S, Flanagan, KL, Macallan, DC

HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::192f5f7183074aa1527420f2f1bbcfdd
https://doi.org/10.1002/rmv.1739

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Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones

Autor: Victor J. Lotti, Wallace T. Ashton, Flanagan Kl, R. S. L. Chang, William J. Greenlee, M. Maccoss, Tsing-Bau Chen, Robert A. Strelitz, Linda L. Chang, Kristie A. Faust

Publikováno v: Journal of Medicinal Chemistry. 36:2558-2568

A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4587c2676c854fde8b9b1e9de11ae78
https://doi.org/10.1021/jm00069a015

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In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist

Autor: Flanagan Kl, Robert A. Gabel, Linda W. Schaffer, Salah D. Kivlighn, William J. Greenlee, Linda L. Chang, Wallace T. Ashton, Terry W. Schorn, Peter K. S. Siegl, Gloria J. Zingaro

Publikováno v: Clinical and experimental hypertension (New York, N.Y. : 1993). 17(6)

The present study was designed to characterize the in vivo pharmacology of L-159,913 (4-[[2'-(N-benzoylsulfamoyl)biphenyl-4-yl]-5butyl-2,4-dihydr o-2- [2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one); a potent All receptor antagonist. In normotens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc142c329088f65a99641d72dd39643e
https://pubmed.ncbi.nlm.nih.gov/7581262

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Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes

Autor: Linda L. Chang, Gloria J. Zingaro, Victor J. Lotti, Salah D. Kivlighn, Flanagan Kl, R. S. L. Chang, S. S. O'malley, Tsing-Bau Chen, Wallace T. Ashton, Peter K. S. Siegl

Publikováno v: Journal of medicinal chemistry. 37(26)

Angiotensin II (AII), the endogenous peptide ligand of the AII receptor, has equivalent high affinity for both the AT1 and AT2 receptor subtypes while most of the reported nonpeptide AII antagonists are AT1-selective. In an effort to identify dual AT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e5969df91f3b001d77b6fa167c0c6
https://pubmed.ncbi.nlm.nih.gov/7799397

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