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Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities.

Autor: Flammer LJ; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Ellis H; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Rivers N; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Caronia L; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Ghidewon MY; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.; University of Pennsylvania, Philadelphia, Pennsylvania, USA., Christensen CM; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Jiang P; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA., Breslin PAS; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.; Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA., Tordoff MG; Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Sep; Vol. 181 (17), pp. 3282-3299. Date of Electronic Publication: 2024 May 14.

Inhibition of Bitter Taste from Oral Tenofovir Alafenamide.

Autor: Schwiebert E; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) erik@discoverybiomed.com., Wang Y; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Xi R; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Choma K; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Streiff J; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Flammer LJ; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Rivers N; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Ozdener MH; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Margolskee RF; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Christensen CM; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Rawson NE; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.)., Jiang P; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) pjiang@monell.org., Breslin PAS; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) pbreslin@monell.org.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2021 May; Vol. 99 (5), pp. 319-327. Date of Electronic Publication: 2021 Apr 06.

Verbal descriptors influence hypothalamic response to low-calorie drinks.

Autor: Veldhuizen MG; The John B. Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, United States ; Department of Psychiatry, 300 George Street, Yale University School of Medicine, New Haven, CT 06511, United States., Nachtigal DJ, Flammer LJ, de Araujo IE, Small DM

Publikováno v: Molecular metabolism [Mol Metab] 2013 Jun 26; Vol. 2 (3), pp. 270-80. Date of Electronic Publication: 2013 Jun 26 (Print Publication: 2013).