Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers.

Autor: Noveck R; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.N.)., Stroes ES; Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (E.G.S.)., Flaim JD; Isis Pharmaceuticals, Inc., Carlsbad, CA (J.A.D.F., B.F.B., S.H., M.J.G., R.M.C.)., Baker BF; Isis Pharmaceuticals, Inc., Carlsbad, CA (J.A.D.F., B.F.B., S.H., M.J.G., R.M.C.)., Hughes S; Isis Pharmaceuticals, Inc., Carlsbad, CA (J.A.D.F., B.F.B., S.H., M.J.G., R.M.C.)., Graham MJ; Isis Pharmaceuticals, Inc., Carlsbad, CA (J.A.D.F., B.F.B., S.H., M.J.G., R.M.C.)., Crooke RM; Isis Pharmaceuticals, Inc., Carlsbad, CA (J.A.D.F., B.F.B., S.H., M.J.G., R.M.C.)., Ridker PM; Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.R.).

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2014 Jul 10; Vol. 3 (4). Date of Electronic Publication: 2014 Jul 10.

Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial.

Autor: Thomas GS; Long Beach Memorial Medical Center, Long Beach, California; University of California, Irvine, Irvine, California. Electronic address: gthomas1@memorialcare.org., Cromwell WC, Ali S, Chin W, Flaim JD, Davidson M

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2013 Dec 10; Vol. 62 (23), pp. 2178-84. Date of Electronic Publication: 2013 Sep 04.

Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia.

Autor: Akdim F; Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands., Visser ME, Tribble DL, Baker BF, Stroes ES, Yu R, Flaim JD, Su J, Stein EA, Kastelein JJ

Publikováno v: The American journal of cardiology [Am J Cardiol] 2010 May 15; Vol. 105 (10), pp. 1413-9. Date of Electronic Publication: 2010 Mar 30.

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial.

Autor: Raal FJ; Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa. frederick.raal@wits.ac.za, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, Lachmann RH, Gaudet D, Tan JL, Chasan-Taber S, Tribble DL, Flaim JD, Crooke ST

Publikováno v: Lancet (London, England) [Lancet] 2010 Mar 20; Vol. 375 (9719), pp. 998-1006.