Generation of a Heteropolycyclic and sp³‐Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence.

Autor: Flagstad, Thomas¹ (AUTHOR), Azevedo, Carlos M. G.¹ (AUTHOR), Troelsen, Nikolaj S.¹ (AUTHOR), Min, Geanna K.¹ (AUTHOR), Macé, Yohan² (AUTHOR), Willaume, Anthony² (AUTHOR), Guilleux, Rachel² (AUTHOR), Velay, Mélanie² (AUTHOR), Bonnet, Karine² (AUTHOR), Morgentin, Remy² (AUTHOR), Nielsen, Thomas E.^3,4 (AUTHOR) ten@sund.ku.dk, Clausen, Mads H.¹ (AUTHOR) mhc@kemi.dtu.dk

Publikováno v: European Journal of Organic Chemistry. 2/7/2019, Vol. 2019 Issue 5, p1061-1076. 16p.

Generation of a Heteropolycyclic and sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence

Autor: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.

Publikováno v: Flagstad, T, Azevedo, C M G, Troelsen, N S, Min, G K, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551
Flagstad, T, Azevedo, C, Troelsen, N S, Min, G, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and Sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/DielsAlder and ROM-RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::93642865fe22b10ef40d237729c570b0
https://curis.ku.dk/portal/da/publications/generation-of-a-heteropolycyclic-and-sp3rich-scaffold-for-library-synthesis-from-a-highly-diastereoselective-petasisdielsalder-and-romrcm-reaction-sequence(472ffe62-c777-4b1d-bb8c-9c609f3bbd36).html

Piperazine inhibitors of bacterial gyrase and topoisomerase iv

Autor: Givskov, Michael, Tolker-Nielsen, Tim, Jakobsen, Tim Holm, Andersen, Jens Bo, Quement, Sebastian Thordal Le, Nielsen, Thomas Eiland, Flagstad, Thomas, Petersen, Mette Terp, Felding, Jakob

Publikováno v: Givskov, M, Tolker-Nielsen, T, Jakobsen, T H, Andersen, J B, Quement, S T L, Nielsen, T E, Flagstad, T, Petersen, M T & Felding, J Sep. 09 2016, Piperazine inhibitors of bacterial gyrase and topoisomerase iv, Patent No. WO2016138988 .

This invention relates to a piperazine derivative having the formula (I), wherein R' is selected from -H, -COOH and -CONH2; Ft" is selected from -H, -COOH and -CONH2 with the proviso that when R' is -COOH or -CONH2 then R" is not -COOH or -CONH2, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1202::6e2fe96dd0c96aa67b655c950adf7b1a
https://orbit.dtu.dk/en/publications/a78dc742-dc7f-43b7-8c64-32e0353d1895

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