Zobrazeno 1 - 10 of 199 pro vyhledávání: '"Flöter Rådestad, A"'
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Akademický článek
DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment
Autor: Chiara Herzog, Allison Jones, Iona Evans, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan, Martin Widschwendter
Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract To individualise breast cancer (BC) prevention, markers to follow a person’s changing environment and health extending beyond static genetic risk scores are required. Here, we analysed cervical and breast DNA methylation (n = 1848) and sin
Externí odkaz: https://doaj.org/article/d0fb94cbd720461bb22d27dfa8de5686
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3
Akademický článek
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Autor: Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising pr
Externí odkaz: https://doaj.org/article/3c4f667ea36343489d62c2a38deb1ee7
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6
Akademický článek
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
Autor: James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan, Martin Widschwendter
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Breast cancer is most commonly diagnosed via a needle biopsy. In this study, the authors show that cervical samples from women with breast cancer have a methylation signature different to that of healthy controls.
Externí odkaz: https://doaj.org/article/b725d68d5d7e432ebbaed51f8f18f528
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7
Akademický článek
Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock
Autor: James E. Barrett, Chiara Herzog, Yoo-Na Kim, Thomas E. Bartlett, Allison Jones, Iona Evans, David Cibula, Michal Zikan, Line Bjørge, Nadia Harbeck, Nicoletta Colombo, Sacha J. Howell, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v: Genome Biology, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Whether discordant tick ra
Externí odkaz: https://doaj.org/article/12a38f2cd1054cb4b89b25ca9f11ff1b
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