Výsledky vyhledávání - "Flávio V Loures"

Akademický článek

Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.

Autor: Flávio V Loures, Marc Röhm, Chrono K Lee, Evelyn Santos, Jennifer P Wang, Charles A Specht, Vera L G Calich, Constantin F Urban, Stuart M Levitz

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004643 (2015)

Plasmacytoid dendritic cells (pDCs) were initially considered as critical for innate immunity to viruses. However, our group has shown that pDCs bind to and inhibit the growth of Aspergillus fumigatus hyphae and that depletion of pDCs renders mice hy

Externí odkaz: https://doaj.org/article/1412dfd8565b407ebdccd4c99047c29b

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Akademický článek

Loss- and Gain-of-Function Approaches Indicate a Dual Role Exerted by Regulatory T Cells in Pulmonary Paracoccidioidomycosis.

Autor: Silvia B Bazan, Tania A Costa, Eliseu Frank de Araújo, Claudia Feriotti, Flávio V Loures, Fernando D Pretel, Vera L G Calich

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004189 (2015)

Paracoccidioidomycosis (PCM), is a pulmonary fungal disease whose severity depends on the adequate development of T cell immunity. Although regulatory T (Treg) cells were shown to control immunity against PCM, deleterious or protective effects were d

Externí odkaz: https://doaj.org/article/e98eded180ce4069870736c75d2773b8

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Akademický článek

Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts.

Autor: Eliseu F Araújo, Flávio V Loures, Silvia B Bazan, Claudia Feriotti, Adriana Pina, Alessandra S Schanoski, Tânia A Costa, Vera L G Calich

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3330 (2014)

Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms that control the severe and mild forms of paracoccidioidomycosis are still unclear. Indolea

Externí odkaz: https://doaj.org/article/a398b8411156411783d030252ec9b61b

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Akademický článek

Mannosyl-recognizing receptors induce an M1-like phenotype in macrophages of susceptible mice but an M2-like phenotype in mice resistant to a fungal infection.

Autor: Claudia Feriotti, Flávio V Loures, Eliseu Frank de Araújo, Tania Alves da Costa, Vera L G Calich

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54845 (2013)

In addition to alpha1,3 glucan, mannan and mannan-linked proteins are expressed in the outer layer of Paracoccidioides brasiliensis yeasts. The recognition of mannosyl residues by multiple pathogen recognition receptors, such as the mannose receptor

Externí odkaz: https://doaj.org/article/5d79cf9d3d36463ba05e235cbf37805b

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Akademický článek

In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology.

Autor: Tânia A Costa, Silvia B Bazan, Claudia Feriotti, Eliseu F Araújo, Ênio J Bassi, Flávio V Loures, Vera L G Calich

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2512 (2013)

BACKGROUND: Cellular immunity is the main defense mechanism in paracoccidioidomycosis (PCM), the most important systemic mycosis in Latin America. Th1 immunity and IFN-γ activated macrophages are fundamental to immunoprotection that is antagonized b

Externí odkaz: https://doaj.org/article/124ff20248934277986a3c67ac8a9589

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Akademický článek

Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis.

Autor: Maíra Felonato, Adriana Pina, Eliseu Frank de Araujo, Flávio V Loures, Silvia B Bazan, Cláudia Feriotti, Vera L G Calich

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e51071 (2012)

Regulatory T (Treg) cells are fundamental in the control of immunity and excessive tissue pathology. In paracoccidioidomycosis, an endemic mycosis of Latin America, the immunoregulatory mechanisms that control the progressive and regressive forms of

Externí odkaz: https://doaj.org/article/7ff8499cdcbb4a9ebf668eae15cf10a0

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The Anti-Biofilm Efficacy of Caffeic Acid Phenethyl Ester (CAPE) In Vitro and a Murine Model of Oral Candidiasis

Autor: Juliana Campos Junqueira, Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Eleftherios Mylonakis, Valéria de Lima Kaminski, Beth Burgwyn Fuchs, Flávio V. Loures, Maíra Terra Garcia

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Candida albicans is the main fungal species associated with the development of oral candidiasis. Currently, therapeutic options for these infections are limited by the adverse effects of antifungal drugs and by the emergence of drug resistant strains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1245e9a74ba8eb13e12b6ea6a5e52f9e

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In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology

Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765c4bd5e9ad34a7f66ec11a204444be
https://www.frontiersin.org/articles/10.3389/fimmu.2021.595343/full

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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis

Autor: Flávio V. Loures, Alessandra S. Schanoski, Joes Nogueira-Neto, Bruno C. Vivanco, Tania Alves da Costa, Vera Lúcia Garcia Calich, Alexandre C. Keller, David A. G. Andrade, Daniela Santoro Rosa, Michelangelo Bauwelz Gonzatti, Patricia Xander

Publikováno v: Journal of Immunology Research, Vol 2021 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to Paracoccidioides brasiliensis infection remains unknown. Using splenocytes from CD1d (CD1d-/-) and iNKT-defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1543368f8cbcce7e3c796c80ddf15e2

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AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection

Autor: Tania Alves da Costa, Vera Lúcia Garcia Calich, Flávio V. Loures, Nycolas W. Preite, Claudia Feriotti, Nayane Alves de Lima Galdino, Eliseu Frank de Araújo

Publikováno v: Frontiers in Immunology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 12 (2021)

In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression by prevalent Th2/Th9 immunity. Treg cells play a dual role, suppressing immunity but also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035cb7a9b28c88b102174fc3df6946e8
https://pubmed.ncbi.nlm.nih.gov/33936043

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